 | Jordan Peele als Rell Williams / Oil Dresden |
 | Keegan-Michael Key als Clarence Goobril / Smoke Dresden |
 | Keanu Reeves als Keanu (voice) |
 | Tiffany Haddish als Hi-C |
 | Method Man als Cheddar |
 | Darrell Britt-Gibson als Trunk |
 | Jason Mitchell als Bud |
 | Jamar Malachi Neighbors als Stitches |
 | Luis Guzmán als Bacon |
 | Will Forte als Hulka |
 | Nia Long als Hannah |
 | Rob Huebel als Spencer |
 | Madison Wolfe als Alexis |
| Jordyn A. Davis als Belle |
| James Yeargain als Donnie |
| Brittany Seymour als Rachel |
 | Richard Holden als Detective Mank |
| Nadiyah Skyy Taylor als Galaxy |
 | Susan McBrien als Hulka's Mom |
 | Jenny Ballard als Officer Jonah |
 | Ian Casselberry als King Diaz |
| Neil Wells als Prison Guard |
 | David A. Cole als Cop #1 |
 | Reginal Varice als Cop #2 |
 | Nicholas Hayner als Guard #2 |
 | Sue-Lynn Ansari als Dancer (uncredited) |
 | Anna Faris als Herself (uncredited) |
| Gino Galento als Narco Guard (uncredited) |
| Maia Kavchak als Drug Girl (uncredited) |
 | Sam Medina als Cartel Leader (uncredited) |
| Peter Atencio | Director |
| Alex Rubens | Writer |
| Jordan Peele | Writer |
| Jas Shelton | Director of Photography |
| Nicholas Monsour | Editor |
| Jennifer Cocker | Stunts |
| Keegan-Michael Key | Producer |
| Jordan Peele | Producer |
| Peter Principato | Producer |
| Joel Zadak | Producer |
| Steve Jablonsky | Original Music Composer |
| Nathan Whitehead | Original Music Composer |
| Aaron Osborne | Production Design |
| Erin Cochran | Art Direction |
| Owl Martin Dwyer | Set Decoration |
| Abby O'Sullivan | Costume Design |
| Brooke Satrazemis | Script Supervisor |
| Susan A. Sullivan | Script Supervisor |
| Steven Mnuchin | Executive Producer |
| Bob Brown | Stunt Coordinator |
| Charles Ingram | Stunt Double |
| Joe Nin Williams | Stunt Double |
| Jennifer Schreck | Set Costumer |
| Lauren Melody Shell | Modeling |
| Vanessa Motta | Utility Stunts |
| Richard Brener | Executive Producer |
| Toby Emmerich | Executive Producer |
| Jon H. Epstein | Utility Stunts |
| Chuck Picerni Jr. | Utility Stunts |
| Casey O'Neill | Stunt Driver |
| Nicole Abellera | Casting |
| Jeanne McCarthy | Casting |
| Stephan Dupuis | Prosthetic Makeup Artist |
| Kevin Haney | Prosthetic Makeup Artist |
| Haley Hinkle | Key Hair Stylist |
| Voni Hinkle | Hair Department Head |
| Crystal Wells | Hairstylist |
| Scott Wheeler | Makeup Department Head |
| Georgianna Whitley | Second Assistant Director |
| Stacy Murphy Gold | First Assistant Director |
| Dave Kelsey | Set Designer |
| Landon Lott | Set Designer |
| Zac Tate | Set Dresser |
| Deb Adair | Sound Re-Recording Mixer |
| Michael Babcock | Supervising Sound Editor |
| Michael Babcock | Sound Designer |
| Gregg Barbanell | Foley Artist |
| Cameron Frankley | Sound Re-Recording Mixer |
| Cameron Frankley | Sound Supervisor |
| Catherine Harper | Foley Artist |
| Tim Hays | Sound Mixer |
| Dan Kenyon | Sound Designer |
| Darrin Mann | Foley Mixer |
| Jon Michaels | Supervising Sound Editor |
| Jon Michaels | ADR Supervisor |
| Chris Welcker | Production Sound Mixer |
| Robert Benavidez | Special Effects Technician |
| Elias Duhe Jr. | Special Effects Technician |
| Matthew James Kutcher | Special Effects Technician |
| Justin Kane Miller | Special Effects Technician |
| Juli Van Brown | Special Effects Technician |
| Kent Johnson | Visual Effects |
| Rocco Passionino | Visual Effects Supervisor |
| Dane Allan Smith | Visual Effects Producer |
| Mike McLaughlin | Gaffer |
