 | Tom Cruise als Roy Miller |
 | Cameron Diaz als June Havens |
 | Peter Sarsgaard als Fitzgerald |
 | Viola Davis als CIA Director Isabel George |
 | Jordi Mollà als Antonio Quintana |
 | Paul Dano als Simon Feck |
 | Maggie Grace als April Havens |
 | Marc Blucas als Rodney |
 | Celia Weston als Molly Knight |
 | Falk Hentschel als Bernhard |
 | Lennie Loftin als Braces |
 | Rich Manley als Danny |
 | Dale Dye als Frank Knight |
 | Gal Gadot als Naomi |
 | Jack O'Connell als Wilmer |
 | Trevor Loomis als Eduardo |
 | Nilaja Sun als Allison |
 | Taylor Treadwell als Gate Agent |
 | Christian Finnegan als Ticket Agent |
 | Nicholas Art als Kid at Airport |
| Brian Dykstra als TSA Officer |
 | Brian Tarantina als Scrap Yard Man |
| Natasha Paczkowski als Petra The Tailor |
| Jerrell Lee Wesley als Fireman Paul |
 | Matthew Lawler als Passerby Agent |
 | Ronn Surels als Flight Attendant |
| Eric Robert Bradshaw Bennett als 18 Wheeler Driver |
| Scott Wahle als Newscaster |
 | Sara Jean Underwood als Newscaster #2 |
| Helen L. Welsh als Neighbor |
 | King Orba als Smuggler |
 | Michael Enright als Engineer |
 | Adam Gregor als Train Cook |
| Mitch E. Bowan als Medivac EMT |
| Gerald T. Carbajal als Doctor in Hallway |
 | Arnold Chon als Gunman with Shotgun (uncredited) |
| James Mangold | Director |
| Patrick O'Neill | Writer |
| Phedon Papamichael | Director of Photography |
| Arnon Milchan | Executive Producer |
| Joe Roth | Executive Producer |
| Steve Pink | Producer |
| José Luis Escolar | Line Producer |
| Todd Garner | Producer |
| Cathy Konrad | Producer |
| Quincy Z. Gunderson | Editor |
| Michael McCusker | Editor |
| Andrew Menzies | Production Design |
| Donna DeSeta | Casting |
| Sarah Katzman | Casting |
| Lisa Beach | Casting |
| Jeffrey Wisniewski | Art Direction |
| Jay Hart | Set Decoration |
| Arianne Phillips | Costume Design |
| Wendy Means | Art Department Coordinator |
| Michael Meinardus | Special Effects Coordinator |
| Regina Cachuela | Animation Director |
| Taylor Carrasco | Animation Director |
| Chad Shattuck | Animation Supervisor |
| Ivy Agregan | Visual Effects Coordinator |
| Janet Muswell | Visual Effects Producer |
| Maurice K. McGuire | Camera Operator |
| Rafael E. Sánchez | Gaffer |
| Gary Dahlquist | Rigging Gaffer |
| Frank Masi | Still Photographer |
| David James | Still Photographer |
| Trevor Loomis | First Assistant Camera |
| Philip Shanahan | First Assistant Camera |
| Kyle Thomas Coker | Casting Associate |
| Jeremy Gordon | Casting Associate |
| Beth Lipari | Casting Associate |
| Robert Q. Mathews | Costume Supervisor |
| Rosa J. Colón | Set Costumer |
| Tom Cummins | Set Costumer |
| Guillaume DeLouche | Armorer |
| Kathrine Gordon | Hair Department Head |
| Kristen Barry | Key Hair Stylist |
| Lona Vigi | Hairstylist |
| Jane Galli | Makeup Department Head |
| Michèle Burke | Makeup Artist |
| Robin Fredriksz | Makeup Artist |
| Steve Baine | Foley |
| John T. Cucci | Foley |
| Dan O'Connell | Foley |
| Steve Bissinger | Sound Effects Editor |
| Doug Jackson | Sound Effects Editor |
| Paul Pirola | Sound Effects Editor |
| Hamilton Sterling | Sound Effects Editor |
| Derek Vanderhorst | Sound Effects Editor |
| Paul Massey | Sound Re-Recording Mixer |
| David Giammarco | Sound Re-Recording Mixer |
| Donald Sylvester | Supervising Sound Editor |
| Andrew Buckland | First Assistant Editor |
| Pau Costa | Special Effects Supervisor |
| Greg Berry | Supervising Art Director |
| Eric Durst | Visual Effects Supervisor |
| Marsha L. Swinton | Associate Producer |
| E. Bennett Walsh | Executive Producer |
| E. Bennett Walsh | Unit Production Manager |
| Robin Sweet | Unit Production Manager |
| Gregg Smrz | Stunt Coordinator |
| Charles Croughwell | Stunt Coordinator |
| Andrew L. Jones | Art Direction |
| Andrew Birdzell | Set Designer |
| Stephen Christensen | Set Designer |
| Paul Richards | Leadman |
| Mark Weissenfluh | Leadman |
| David Moreau | Conceptual Design |
| Jim Behnke | Production Manager |
| David Luckenbach | Camera Operator |
| Lee Orloff | Production Sound Mixer |
| Jeffrey A. Humphreys | Boom Operator |
| Anna Rane | Script Supervisor |
| Karen Teneyck | Assistant Art Director |
| Jim Wallis | Assistant Art Director |
| Giacomo Ghiazza | Storyboard |
| Mick Cummings | Set Decoration Buyer |
| Joseph Carson | Visual Effects Editor |
| David Giammarco | Sound Mixer |
| Paul Massey | Sound Mixer |
| Ted Caplan | Music Editor |
| Ryan Ganimian | Post Production Assistant |
| Daniel Nussbaum | Post Production Assistant |
| Patrick Hoeschen | Best Boy Electric |
| Frans Wetterings III | Best Boy Electric |
| Laura Morgan | Assistant Costume Designer |
| Carmen Butts | Hairstylist |
| Gregory Alpert | Location Manager |
| Jeff N. MacLean | Location Manager |
| Luke Ramsey | Location Manager |
| Kwame Parker | Production Supervisor |
| Steve Cainas | Production Coordinator |
| Lori Hornung | Production Coordinator |
| Anthony Syracuse | Construction Coordinator |
| John Stone | Construction Coordinator |
| Guy Adan | Unit Publicist |
| Gary Duncan | Picture Car Coordinator |
| Thomas A. Carlson | Music Editor |
| Giorgio Armani | Thanks |
| Ralph Lauren | Thanks |
| David V. Butler | Dialogue Editor |
| Russell Farmarco | Dialogue Editor |
| Kris Peck | Property Master |
| Josh Bleibtreu | Second Unit Director of Photography |
| John Powell | Original Music Composer |
| Daniel S. Irwin | ADR Editor |
| Nancy Nugent | ADR Editor |
| Natalie Thompson | Production Manager |
| Nicholas Mastandrea | First Assistant Director |
| Maria Mantia | Second Assistant Director |
| Christian Wood | Digital Compositor |
| Ainslie Thomas | VFX Artist |
| Ainslie Thomas | Production Coordinator |
| Cheryl Wheeler Duncan | Stunts |
| Ronn Surels | Fight Choreographer |
| Jimmy N. Roberts | Stunts |
| Donna Evans | Stunt Driver |
| Rosine 'Ace' Hatem | Stunts |
| Jessie Graff | Stunts |
| Kimberly Shannon Murphy | Stunt Double |
| Roy Farfel | Stunts |
| Corey Michael Eubanks | Stunts |
| Dean Bailey | Stunts |
| Matt Baker | Stunts |
| Bill Anagnos | Stunts |
| Eddie Braun | Stunts |
| Chris Brewster | Stunts |
| Holland Diaz | Stunts |
| Nash Edgerton | Stunts |
| Mickey Giacomazzi | Stunts |
| Scotty Richards | Stunt Coordinator |
| Brett Smrz | Stunts |
| Nicole Surels | Stunts |
| Darryl Wooten | Stunt Driver |
| Lee Cunningham | Stunt Driver |
| Keii Johnston | Stunts |
| Hubie Kerns Jr. | Stunt Driver |
| Casey O'Neill | Stunt Double |
| Jimmy N. Roberts | Stunt Double |
| Chris Palermo | Stunts |
| Brian Smrz | Second Unit Director |
| Dane Farwell | Stunts |
| Lisa Hoyle | Stunts |
