 | Mel Gibson als Martin Riggs |
 | Danny Glover als Roger Murtaugh |
 | Gary Busey als Mr. Joshua |
 | Mitchell Ryan als General Peter McAllister |
 | Tom Atkins als Michael Hunsaker |
 | Darlene Love als Trish Murtaugh |
 | Traci Wolfe als Rianne Murtaugh |
 | Jackie Swanson als Amanda Hunsaker |
 | Damon Hines als Nick Murtaugh |
 | Ebonie Smith als Carrie Murtaugh |
 | Bill Kalmenson als Beat Cop |
 | Lycia Naff als Dixie |
 | Patrick Cameron als Cop #1 |
 | Don Gordon als Cop #2 |
 | Jimmie F. Skaggs als Drug Dealer #1 |
 | Jason Ronard als Drug Dealer #2 |
 | Blackie Dammett als Drug Dealer #3 |
| Gail Bowman als Cop |
| Robert Fol als Cop |
| Selma Archerd als Policewoman |
| Richard B. Whitaker als Police Officer |
 | Mary Ellen Trainor als Psychologist |
 | Steve Kahan als Captain Ed Murphy |
 | Jack Thibeau als Sergeant McCaskey |
 | Grand L. Bush als Boyette |
 | Ed O'Ross als Mendez |
 | Gustav Vintas als Gustaf |
 | Paul Tuerpe als Mercenary |
 | Chad Hayes als Mercenary |
 | Chris D. als Mercenary |
 | Sven-Ole Thorsen als Mercenary |
| Peter DuPont als Mercenary |
 | Gilles Kohler als Mercenary |
| Cedric Adams als Mercenary |
| Jim J. Poslof als Mercenary |
 | Al Leong als Endo |
| Michael Shaner als McCleary |
| Natalie Zimmerman als Patrol Cop |
| Deborah Dismukes als Blonde on Bike |
| Cheryl Baker als Girl in Shower #1 |
 | Terri Lynn Doss als Girl in Shower #2 |
| Sharon K. Brecke als Girl in Shower #3 |
| Donald Gooden als Alfred |
| Alphonse Philippe Mouzon als Alfred's Friend #1 |
| Shaun Hunter als Alfred's Friend #2 |
| Everitt Wayne Collins Jr. als Alfred's Friend #3 |
 | Lenny Juliano als Patrol Cop |
 | Henry Brown als Plainclothes Cop |
| Brian Strohm als Family Friend |
| Teresa Kadotani als Hooker |
| Frank Reinhard als Beat Cop |
| John O'Neill als Police Officer in Car #1 |
| Tom Noga als Police Officer in Car #2 |
| Larry Clardy als Policeman (uncredited) |
 | Renée Estevez als Underage Hooker (uncredited) |
 | Bob Harks als Priest (uncredited) |
 | Kathleen Harrison als Mrs. Dilber (archive footage) (uncredited) |
| Conrad Hurtt als Crime Scene Officer (uncredited) |
 | Mic Rodgers als Bus Driver (uncredited) |
 | Joan Severance als Girl in Black Playsuit (uncredited) |
 | Chris Tashima als Fire Rescue Attendant (uncredited) |
 | Norman D. Wilson als Bartender (uncredited) |
| Joel Silver | Producer |
| Eric Clapton | Original Music Composer |
| Stephen Goldblatt | Director of Photography |
| Stuart Baird | Editor |
| Michael Kamen | Original Music Composer |
| J. Michael Riva | Production Design |
| Marion Dougherty | Casting |
| Marvin March | Set Decoration |
| Richard Donner | Director |
| Richard Donner | Producer |
| Shane Black | Screenplay |
| Mary Malin | Costume Design |
| Mary Peters | Stunts |
| Scott H. Eddo | Makeup Artist |
| Jennie Lew Tugend | Associate Producer |
| Steve Perry | Unit Production Manager |
| Benjamin Rosenberg | First Assistant Director |
| Terry Miller | Second Assistant Director |
| Bill Nelson | Production Sound Mixer |
| Jules Strasser | Boom Operator |
| Mychal D. Smith | Cableman |
| Dar Robinson | Stunts |
| Mic Rodgers | Stunts |
| John Alden | Stunts |
| Billy Hank Hooker | Stunts |
| Gregory J. Barnett | Stunts |
| Jeff Imada | Stunts |
| Jophery C. Brown | Stunts |
| Mark Lonsdale | Stunts |
| Dana Mackey | Stunts |
| Monty Cox | Stunts |
| Bennie Moore | Stunts |
| Jeffrey J. Dashnaw | Stunts |
| Jimmy Nickerson | Stunts |
| Steve DeFrance | Stunts |
| Mike De Luna | Stunts |
| Chad Randall | Stunts |
| Shane Dixon | Stunts |
| Ronnie Rondell Jr. | Stunts |
| David R. Ellis | Stunts |
| Keith Tellez | Stunts |
| Richard M. Ellis | Stunts |
| Cisco Valderrama | Stunts |
| Donna Evans | Stunts |
| Randell Dennis Widner | Stunts |
| Diane Hetfield | Stunts |
| Glenn R. Wilder | Stunts |
| Freddie Hice | Stunts |
| Eva Anna Andry | Assistant Art Director |
| Virginia Randolph-Weaver | Assistant Art Director |
| Richard Walden | Camera Operator |
| Geary McLeod | First Assistant Camera |
| Calmar Roberts | First Assistant Camera |
| Bess Wiley | Second Assistant Camera |
| Rick Whitesman | Second Assistant Camera |
| Robert G. Henderson | Supervising Sound Editor |
| Alan Robert Murray | Supervising Sound Editor |
| Jay Engel | Supervising ADR Editor |
| Christopher Brooks | Music Editor |
| Jack Eberhart | Leadman |
| Michael Strong | Gaffer |
| Bill King | Best Boy Electric |
| Tim McArdle | Rigging Gaffer |
| Charles Saldaña | Key Grip |
| Ron Peebles | Best Boy Grip |
| Kirk Bales | Dolly Grip |
| Erik L. Nelson | Property Master |
| Barry Francis Delaney | Costume Supervisor |
| Paki Wolfe | Assistant Costume Designer |
| Dallas D. Dornan | Costumer |
| Paul Abascal | Hairstylist |
| Marion Tumen | Script Supervisor |
| Julie Adams | Dialogue Coach |
| David Israel | Location Manager |
| John Panzarella | Location Manager |
| Paula Shaw | Location Manager |
| Bobby Bass | Stunt Coordinator |
| Frank M. Holgate | Aerial Director of Photography |
| Chuck Gaspar | Special Effects Coordinator |
| Willie E. Simmons, Jr. | Additional Second Assistant Director |
| Laura Hoffman | Production Secretary |
| Jan Garner | Production Accountant |
| Katherine Ann Moore | Unit Publicist |
| John R. Shannon | Still Photographer |
| Les Fresholtz | Sound Re-Recording Mixer |
| Rick Alexander | Sound Re-Recording Mixer |
| Vern Poore | Sound Re-Recording Mixer |
| William J. Meshover | Assistant Editor |
| Juno J. Ellis | ADR Editor |
| Richard Oswald | Sound Editor |
| David M. Horton | Sound Editor |
| Bruce Lacey | Sound Editor |
| Gordon Davidson | Sound Editor |
| Neil Burrow | Sound Editor |
| Milton C. Burrow | Sound Editor |
| George Stokes | Construction Coordinator |
| James F. Orendorff | Construction Foreman |
| Myra Hill | Transportation Coordinator |
| Annie Ellis | Stunts |
| James Guthrie | Music Producer |
