 | Mel Gibson als Martin Riggs |
 | Danny Glover als Roger Murtaugh |
 | Joe Pesci als Leo Getz |
 | Joss Ackland als Arjen Rudd |
 | Derrick O'Connor als Pieter Vorstedt |
 | Patsy Kensit als Rika Van Den Haas |
 | Darlene Love als Trish Murtaugh |
 | Steve Kahan als Captain Ed Murphy |
 | Mark Rolston als Hans |
 | Jenette Goldstein als Meagan Shapiro |
 | Dean Norris als Tim Cavanaugh |
 | Juney Smith als Tom Wyler |
 | Nestor Serrano als Eddie Estaban |
 | Philip Suriano als Joseph Ragucci |
 | Grand L. Bush als Jerry Collins |
| Allan Dean Moore als George |
 | Jack McGee als Carpenter |
 | Mary Ellen Trainor als Police Psychiatrist |
 | Traci Wolfe als Rianne Murtaugh |
 | Ebonie Smith als Carrie Murtaugh |
 | Damon Hines als Nick Murtaugh |
 | Tony Carreiro als Marcelli |
 | Sherman Howard als Hitman |
 | Pat Skipper als Hitman |
 | Jim Piddock als Consulate Envoy |
 | David Marciano als Cop #1 |
 | Tommy Hinkley als Cop #2 |
| Lionel Douglass als Officer Friesen |
 | James Oliver als Officer Moss |
 | Marian Collier als Poolside Card Player |
 | Norman D. Wilson als Detective in Squad Room |
 | Paul Tuerpe als Hitman |
| Philip Maurice Miller als Hitman |
| Bruce Young als Hitman |
| Guy Mack als Hitman |
 | Danny Wynands als Hitman |
| Robert Fol als Consulate Guard |
| Virginia Shannon als Consulate Office Worker |
| Dan Ondrejko als Consulate Clerk #2 |
 | Kenneth Tigar als Jarvis Becker - Bomb Squad Leader |
| Jim Birge als Bomb Squad Cop #2 |
| Jeanne McGuire als Computer Operator #1 |
| Catherine Guel als Computer Operator #2 |
| Salim Jaidi als Policeman |
| Al Weber Jr. als Poolside Card Player |
| Edward J. Rosen als Poolside Card Player |
| Jay Della als Poolside Card Player |
| Orlando Bonner als Tow Truck Driver |
| Cynthia Burr als Owner of Honda |
 | Todd Blood als Street Extra (uncredited) |
| Jorga Caye als Ice Hockey Fan (uncredited) |
| Larry Clardy als Policeman (uncredited) |
 | J. Mills Goodloe als Eddie (uncredited) |
| Lana Houston als Man in Condom Television Commercial (uncredited) |
| Conrad Hurtt als Squad Room Officer (uncredited) |
| Bettina M. Johnson als Squad Room Woman (uncredited) |
 | Beau Lotterman als Policeman (uncredited) |
| Fred Moon als Bus Stop Guy (uncredited) |
 | Patrick Cameron als Bomb Squad Cop #3 |
| Jeffrey Boam | Screenplay |
| Richard Berger | Art Direction |
| Richard Donner | Producer |
| Richard Donner | Director |
| Marion Dougherty | Casting |
| J. Michael Riva | Production Design |
| Joel Silver | Producer |
| Stephen Goldblatt | Director of Photography |
| Stuart Baird | Editor |
| Marvin March | Set Decoration |
| Michael Kamen | Original Music Composer |
| David Sanborn | Original Music Composer |
| Eric Clapton | Original Music Composer |
| Gail Levin | Casting |
| Steve Perry | Co-Producer |
| Shane Black | Story |
| Jennie Lew Tugend | Co-Producer |
| Warren Murphy | Story |
| Peter Frankfurt | Associate Producer |
| John Villarino | Construction Coordinator |
| Dianne Wager | Set Designer |
| Frank DeMichelis | Craft Service |
| Michael Denering | Scenic Artist |
| Matt Sweeney | Special Effects Coordinator |
| Steve Perry | Unit Production Manager |
| Michael Kamen | Orchestrator |
| Geary McLeod | First Assistant Camera |
| Dan Pemberton | Propmaker |
| Charlie Picerni | Stunt Coordinator |
| Sherman Labby | Production Illustrator |
| Charles Saldaña | Key Grip |
| Paul Abascal | Hairstylist |
| Christopher Brooks | Music Editor |
| Willie D. Burton | Production Sound Mixer |
| Marvin E. Lewis | Boom Operator |
| Frank M. Holgate | Aerial Camera |
| Barry Francis Delaney | Costume Supervisor |
| Scott H. Eddo | Makeup Artist |
| Erik L. Nelson | Property Master |
| Gregory Manson | Production Accountant |
| Jack Lietzke | Transportation Coordinator |
| Michael Klastorin | Unit Publicist |
| Amy Jackson | Production Office Assistant |
| David Israel | Location Manager |
| Julie Adams | Dialect Coach |
| Terry Miller | First Assistant Director |
| Bub Asman | Sound Editor |
| Virginia Randolph-Weaver | Art Direction |
| Darrin Martin | Assistant Sound Editor |
| John R. Shannon | Still Photographer |
| Richmond G. Cogswell | Video Assist Operator |
| Mike Villarino | Construction Foreman |
| Robert G. Henderson | Supervising Sound Editor |
| Gregory J. Barnett | Stunts |
| Stephen McLaughlin | Music Producer |
| Greg Orloff | Foley Mixer |
| Gary F. Kieldrup | Assistant Property Master |
| James Simcik | ADR Editor |
| John Roesch | Foley Artist |
| Albert Cho | Second Second Assistant Director |
| Vicky Snow | Costumer |
| Steve Perry | Second Unit Director |
| Gilbert O. Parra | Technical Advisor |
| Gary Holt | Chief Lighting Technician |
| Mic Rodgers | Stunt Double |
| Kristin Dewey | Assistant Location Manager |
| Jay Engel | Supervising ADR Editor |
| Craig Lietzke | Stunt Driver |
| Carolyn Tapp | Foley Recordist |
| Kirk Bales | Second Assistant Camera |
| Lisa Cogswell | Production Secretary |
| Charles A. Tamburro | Aerial Coordinator |
| Bob E. Krattiger | Assistant Chief Lighting Technician |
| Danny Falkengren | Dolly Grip |
| Dick Ziker | Stunts |
| Nancy Hansen | Script Supervisor |
| Michael Alan Kahn | Second Assistant Director |
| Jophery C. Brown | Stunts |
| Shane Black | Characters |
| Mark Canton | Executive In Charge Of Production |
| Charlie Picerni | Second Unit Director |
| Paul J. Campanella | Standby Painter |
| Jack Eberhart | Leadman |
| Marc Fambro | Carpenter |
| Jaymes Hinkle | Scenic Artist |
| David J. Negrón Jr. | Storyboard Artist |
| Rick Alexander | Sound Re-Recording Mixer |
| Neil Burrow | Sound Editor |
| Virginia Cook-McGowan | Sound Editor |
| Teri E. Dorman | Sound Editor |
| Les Fresholtz | Sound Re-Recording Mixer |
| Robert W. Harris | Cableman |
| David M. Horton | Sound Editor |
| Joseph A. Ippolito | Sound Editor |
| Michael Jiron | Sound Re-Recording Mixer |
| Karen Minahan | Assistant Sound Editor |
| Alan Robert Murray | Supervising Sound Editor |
| Walter Newman | Sound Editor |
| Vern Poore | Sound Re-Recording Mixer |
| Hank Salerno | Supervising ADR Editor |
| Brooke Henderson Ward | Assistant Sound Editor |
| Marshall Winn | Sound Editor |
| Ellen Heuer | Foley Artist |
| Joseph T. Sabella | Foley Artist |
| Bill Voigtlander | ADR Editor |
| Calvin Joe Acord | Special Effects |
| Jon G. Belyeu | Special Effects Manager |
| Chris Burton | Special Effects |
| Larry L. Fuentes | Special Effects |
| Don Hathaway | Special Effects |
| Richard L. Hill | Special Effects |
| Steve Luport | Special Effects |
| David Peterson | Special Effects |
| Paul Sabourin | Special Effects |
| Jim Schwalm | Special Effects |
| Doyle Smiley | Special Effects |
| Bob Stoker | Special Effects |
| Lucinda Strub | Special Effects |
| Fred Tessaro | Special Effects |
| Greg C. Jensen | Special Effects |
| Steve Boyum | Stunts |
| Janet Brady | Stunts |
| David Burton | Stunts |
| Steven Chambers | Stunts |
| Gilbert B. Combs | Stunts |
| Gary Davis | Stunts |
| Eddy Donno | Stunts |
| Sparky Edmonston | Stunts |
| Kenny Endoso | Stunts |
| Gary Epper | Stunts |
| Tony Epper | Stunts |
| James M. Halty | Stunts |
| Freddie Hice | Stunts |
| Billy Hank Hooker | Stunts |
| Buddy Joe Hooker | Stunts |
| Norman Howell | Stunts |
| Tommy J. Huff | Stunts |
| Matt Johnston | Stunts |
| Gary McLarty | Stunts |
| John C. Meier | Stunts |
| Bennie Moore | Stunts |
| Frank Orsatti | Stunts |
| Victor Paul | Stunts |
| Chuck Picerni Jr. | Stunts |
| Charlie Picerni | Stunts |
| Steve Picerni | Stunts |
| Chad Randall | Stunts |
| Mic Rodgers | Stunts |
| Mic Rodgers | Stunt Coordinator |
| Danny Rogers | Stunts |
| R.A. Rondell | Stunts |
| Scott Wilder | Stunts |
| Lane Leavitt | Stunts |
| Keith Tellez | Stunts |
| Tommy Mack Turvey | Stunts |
| Eddie L. Watkins | Stunts |
| Ric Roman Waugh | Stunts |
| Malcolm Bryce | Lighting Technician |
| Ray De La Motte | Camera Operator |
| Frank M. Holgate | Underwater Camera |
| Bill Krattiger | Lighting Technician |
| Hal Nelson | Best Boy Grip |
| Stephen St. John | Camera Operator |
| Bess Wiley | Second Assistant Camera |
| Stephen Ashley Blake | Second Unit Director of Photography |
| John Earl Burnett | First Assistant Camera |
| Adam Glick | Lighting Technician |
| Horace Jordan | First Assistant Camera |
| Damon Marcellino | Lighting Technician |
| Robert D. McBride | Camera Operator |
| Barbara Siebert | Costumer |
| Michael Voght | Costumer |
| David Mann | Assistant Editor |
| William J. Meshover | Assistant Editor |
| Kevin Stitt | Assistant Editor |
| Joel Marx | Location Manager |
| Antoinette Simmrin | Location Manager |
| Bruce Babcock | Orchestrator |
| Chris Boardman | Orchestrator |
| Philip Giffin | Orchestrator |
| Tom Boyd | Musician |
| Tommy Johnson | Musician |
| Michael Kamen | Conductor |
| Michael Kamen | Musician |
| Alan Kaplan | Musician |
| Norman Ludwin | Musician |
| Malcolm McNab | Musician |
| Richard Nash | Musician |
| James Thatcher | Musician |
| Louise Di Tullio | Musician |
| Vince De Rosa | Musician |
| Julie Pitkanen | Script Supervisor |
| Robert Mark Kamen | Script Editor |
| John M. Woodward | Transportation Captain |
| Lisa Cogswell | Production Coordinator |
| Alicia Rivera Frankl | Production Accountant |
| Michael Papac | Weapons Master |
