 | Oscar Isaac als Will Dempsey |
 | Olivia Wilde als Abby Dempsey |
 | Annette Bening als Dr. Cait Morris |
 | Antonio Banderas als Vincent Saccione |
 | Mandy Patinkin als Irwin Dempsey |
 | Jean Smart als Linda Dempsey |
 | Olivia Cooke als Dylan Dempsey |
 | Sergio Peris-Mencheta als Javier González |
 | Laia Costa als Isabel Díaz |
 | Àlex Monner als Rodrigo González Díaz |
 | Isabel Durant als Shari Dickstein |
 | Lorenza Izzo als Elena Dempsey-González |
 | Samuel L. Jackson als Self |
 | Jake Robinson als Henry / Hero |
 | Adrián Marrero als Rodrigo (7-10 Years Old) |
 | Kya Kruse als Young Dylan |
 | Charlie Thurston als Jack |
 | Gabby Bryan als Elizabeth |
 | Jordana Rose als Abby (5-7 Years Old) |
 | Caitlin Carmichael als Abby (11-13 Years Old) |
 | Bryant Carroll als Uncle Joe |
 | Carmela Lloret als Rodrigo's Therapist |
 | Grace Song als Female Barista |
 | Micah Stock als Barista |
 | Tony Manna als Manager |
 | Yvonne Szacki als Vet |
 | Noah Gaynor als Hot Frat Guy |
 | Ed Crescimanni als Therapist #4 |
 | Zach Page als Bandmember |
| Brian Deodat als Bandmember #2 |
 | Joe Apollonio als Drunk at Bar #1 |
| Mikaela Steele als Bar Patron |
| Manuel Ramos Morilla als Laborer |
| María Dolores Rodríguez Villegas als Flower Seller |
 | Carmen Vique Rodríguez als Beautiful Woman |
| David Freedman als Magician |
| Theodore Mejia als Spanish Speaking Tourist #1 |
 | Caridad Montanez als Spanish Speaking Tourist #2 |
| Javier Verdugo Luque als Rodrigo (10 yrs) |
| Pablo Lagüens Abad als Rodrigo (13 yrs) |
| Yeray Alba León als Rodrigo (14 yrs) |
 | Rehan als Doctor |
| Dale Nussbaum als Professor |
| María Dolores López Vera als Nurse |
| Dan Fogelman | Director |
| Ben Browning | Executive Producer |
| Wyck Godfrey | Producer |
| Alison Cohen | Executive Producer |
| Milan Popelka | Executive Producer |
| Brett Pawlak | Director of Photography |
| Harry Cohen | Sound Effects Designer |
| Hector C. Gika | Sound Editor |
| Marie-Claude Lafontaine | Visual Effects Producer |
| Isaac Klausner | Executive Producer |
| Gerald Sullivan | Production Design |
| Ron von Blomberg | Set Decoration |
| Trish Seeney | Makeup Department Head |
| Vico Sharabani | Visual Effects Supervisor |
| Shannen Walsh | Visual Effects Coordinator |
| Jackie Zhou | Sound Editor |
| Kat Percy | Hair Department Head |
| Julie Monroe | Editor |
| JT Franchuk | Key Hair Stylist |
| Erika Hampson | Co-Producer |
| John Papsidera | Casting |
| Melissa Toth | Costume Design |
| Martha Melendez | Key Makeup Artist |
| Julia Heymans | Art Direction |
| Marty Bowen | Producer |
| Glen Basner | Executive Producer |
| Federico Jusid | Original Music Composer |
| Jean-François Ferland | Visual Effects Supervisor |
| Steven Weigle | Visual Effects Producer |
| Michael Jackman | Co-Producer |
| Asaf Yeger | Visual Effects Supervisor |
| Aaron Ryder | Producer |
| Adrián Guerra | Executive Producer |
| Jenny Caceres | First Assistant Editor |
| Luciano Acuna Jr. | Stunts |
| Season Kent | Music Supervisor |
| Kachina Dechert | Stunt Double |
| Chris Cenatiempo | Stunt Coordinator |
| Dan Fogelman | Producer |
| Wylie Stateman | Supervising Sound Editor |
| Dan Fogelman | Writer |
| Erika Hampson | Unit Production Manager |
| Jolian Blevins | Production Supervisor |
| Vincent Giarratano | Second Assistant Director |
| Brian Smyj | Stunt Coordinator |
| Eric Hoehn | Supervising Sound Editor |
| Julie A. Bloom | First Assistant Director |
| John Cenatiempo | Stunt Coordinator |
| John Finnerty Jr. | Stunts |
| Mark Russell | Visual Effects Supervisor |
| Warren E. Hull | Stunts |
| Mike Carbone | Electrician |
| Chris Alexander | Set Dresser |
| Rick Guzman | Set Dresser |
| Peter Bundrick | Key Carpenter |
| Cole Bylander | Costume Coordinator |
| Ryann Fraser | Production Office Assistant |
| Barry Molloy | Driver |
| Robert Richards | Driver |
| Carlos Chacon | Driver |
| Gary A. Hecker | Foley Artist |
| Pedro Atienzar | CG Artist |
| Kelsey Drown | Compositor |
| Leonore Zydel | Set Dresser |
| Robert Dillon | Carpenter |
| Bruce J. Paquette | Propmaker |
| Jake Schnesel | Producer's Assistant |
| Matthew Crothamel | Location Coordinator |
| Kim Winther | Casting Associate |
| Jason Dowd | Driver |
| Stephen Ferro | Driver |
| Randy Singer | Foley Mixer |
| Whitney Pilzer | Music Coordinator |
| Gustavo Gini | Orchestrator |
| Philippe Cournoyer | Compositor |
| Jessica Francoeur-Ducharme | Compositor |
| Andrew Juhl | First Assistant "A" Camera |
| Russell DeYoung | Scenic Artist |
| Allison Howe | Boom Operator |
| Sydney Niegos | Set Production Assistant |
| Christine Boehm | Set Medic |
| Lindsay Medeiros | First Assistant Accountant |
| Chris Wos | Assistant Location Manager |
| Brad Kenny | Extras Casting |
| Juan Byran | Driver |
| John Curry | Driver |
| Andrew Gilbert | Chef |
| Kemma Filby | Post Production Coordinator |
| Barbara Harris | ADR Voice Casting |
| Aaron Raff | Visual Effects Supervisor |
| David Décoste | Compositor |
| Kevin Kaim | Digital Intermediate Assistant |
| Gail Reilly | Set Dresser |
| Iosif Yusupov | Scenic Artist |
| Edgard Acevedo | Set Painter |
| Gabriella Ramirez | Set Costumer |
| Nick Jaco Collins | Second Second Assistant Director |
| Gina Berceau | Set Production Assistant |
| William Dowd | Driver |
| Mark Lipari | Driver |
| Jacob Meis | Chef |
| Charles M. Barsamian | Music Consultant |
| Pierre-David Myles | Visual Effects Coordinator |
| Maxime Desforges | Compositor |
| Jackson Lewis | Loader |
| Tricia Peck | Set Decoration Buyer |
| Katie Clinebelle | Set Dresser |
| Jack Mortellaro Jr. | Set Dresser |
| Chris Zuch | Construction Grip |
| Colleen Ehrlich | Assistant Costume Designer |
| Lizz Dorovitsine | Production Office Assistant |
| Jeffrey Catlett | Actor's Assistant |
| John Hicks, Jr. | Driver |
| Thomas Cepeda | Musician |
| Elias Bermudez | Visual Effects Coordinator |
| Bryan Hsu | Compositor |
| Kachina Dechert | Stunts |
| Cory Barth | Best Boy Grip |
| Tim Zydel | Leadman |
| David J. Schwartz | Production Sound Mixer |
| Christine Domaniecki | Makeup Artist |
| Annie Sizemore | Production Office Assistant |
| Anthony Pennachio | Set Production Assistant |
| Norman Gibbons | Driver |
| Federico Jusid | Orchestrator |
| Juan Cortés | Music Programmer |
| Maxime Desforges | Visual Effects Production Assistant |
| Trevor Fields | Generator Operator |
| Scott Kelly | Utility Stunts |
| Timothy Staab | Driver |
| Derek Willis | Chef |
| Tom Kramer | Music Editor |
| Meghan Kozlosky | Music Consultant |
| Adrián Foulkes | Music Programmer |
| Mateo Márquez | Digital Intermediate Assistant |
| Derek Gross | Gaffer |
| David Kavanaugh | Best Boy Electric |
| Pasram Goberdhan | Set Dresser |
| Daisy Curbeon | Additional Hairstylist |
| Hunter Lydon | Extras Casting |
| James Harkerss | Transportation Captain |
| Tom O'Connor | Transportation Co-Captain |
| Lorenzo Zanini | Loader |
| Eva Z. Cabrera | Script Supervisor |
| Matthew Vidalis | Graphic Designer |
| Nancy Branton | Scenic Artist |
| Elizabeth Neveu | Assistant Property Master |
| Emily Fischer | Extras Casting |
| James Quinn | Camera Car |
| Rosario Sessa, Jr. | Driver |
| Chris Esposito | Driver |
| Joseph Gonzalez | Driver |
| John Harrington | Driver |
| Adrián Foulkes | Musician |
| Jon Pack | Still Photographer |
| Patrick Benvenuto | Carpenter |
| Renato Quiridumbay | Shop Electric |
| Jarad Hrusovsky | Producer's Assistant |
| Michele Baker | Location Manager |
| John Rios Smith | Assistant Craft Service |
| Federico Jusid | Musician |
| Gabi Martínez | Musician |
| Peter Pejtsik | Conductor |
| Greg Radcliffe | Compositor |
| Kevin Szczepanski | Online Editor |
| Dave Isern | "A" Camera Operator |
| Hiram Velez | Set Dresser |
| Henry Wulster | Set Dresser |
| Richard Hebrank | Construction Coordinator |
| Joseph Galione | Special Effects Technician |
| Erick Majano | Location Assistant |
| Emily Bohbrink | Casting Assistant |
| Juan Cortés | Musician |
| Sean Dunckley | Digital Intermediate Colorist |
| Devin Donegan | Video Assist Operator |
| Tom LaVecchia | On Set Dresser |
| Jose Rubi | Set Dresser |
| Hermes Parga | Set Dresser |
| Sheila Grover | Costume Supervisor |
| Matthew H. Wiesner | Location Scout |
| Leo Marcil | Assistant Sound Designer |
| Gregg Swiatlowski | Dialogue Editor |
| Federico Jusid | Music Programmer |
| Tracey Phillips-Boone | Costume Supervisor |
| Anthony Pennachio | Additional Second Assistant Director |
| Victor A. Pineda | Payroll Accountant |
| Dean Mozian | Digital Intermediate Assistant |
| Rachel Schneider | Post Production Accountant |
| Frank Larson | "B" Camera Operator |
| Samuel Herbig | Electrician |
| Chris Cazavilan | Dolly Grip |
| Conrad V. Brink Jr. | Special Effects Coordinator |
| Nick Hexner | Production Office Assistant |
| Dara Eliacin | Producer's Assistant |
| Jerry Hemraj | Driver |
| Adrián Foulkes | Sound Designer |
| Jose L. Marin | Compositor |
| Tonya Smay | Compositor |
| Carolyn Cury | Digital Intermediate Producer |
| Blake Johnson | Second Assistant "A" Camera |
| Tori Lancaster | Art Department Coordinator |
| Alex Cables | Set Dresser |
| Mike Drury | Assistant Property Master |
| Laura Calcagni | Production Coordinator |
| Emily Aragones | Set Production Assistant |
| Mariarosa Calderon | Production Accountant |
| Dominique Gold | Location Assistant |
| Michael Papa | Camera Car |
| Daniel Cialini | Driver |
| Eric Hoehn | Sound Re-Recording Mixer |
| Josh Child | Compositor |
| Djuna Wahlrab | Compositor |
| Doug Durant | First Assistant "B" Camera |
| Gregory Pace | Second Assistant "B" Camera |
| Matt Harding | Loader |
| Cesar Baptista | Key Grip |
| Matt Marks | Property Master |
| Christy Illius | Utility Sound |
| Brian Smyj | Utility Stunts |
| Gilbert Gertsen | Special Effects Supervisor |
| Rosie Fine | Production Secretary |
| Aaron Aldridge | Key Set Production Assistant |
| David Conelli | Camera Car |
| Melvin Reyes | Assistant Craft Service |
| Ale Martí | Musician |
| Sergio Menem | Musician |
| Valérie Dugas | Compositor |
| Don Hewitt Sr. | Stunt Driver |
| David Ott | Utility Stunts |
| David Ott | Stunt Driver |
