 | Catherine Keener als Michelle Marks |
 | Brenda Blethyn als Jane Marks |
 | Emily Mortimer als Elizabebeth Marks |
 | Raven Goodwin als Annie Marks |
 | Aunjanue Ellis-Taylor als Lorraine |
 | Clark Gregg als Bill |
 | Jake Gyllenhaal als Jordan |
 | James Le Gros als Paul |
 | Michael Nouri als Dr. Crane |
 | Dermot Mulroney als Kevin McCabe |
 | Troy Ruptash als Photographer (voice) |
 | Ileen Getz als Saleswoman |
 | Kristen Dalton als Saleswoman |
 | Romy Rosemont als Dr. Debbie Waldman |
| Brooke Allison als Pool Administrator |
| Jennifer Zehnder als Teased Girl |
 | Ashlynn Rose als Maddy |
 | Dreya Weber als Donna |
| Christine Mourad als Cindy, Elizabeth's Agent |
 | Mariah O'Brien als Kevin's TV Co-Star |
| Jeanne McCarthy als Casting Director |
 | Evan Mirand als Director |
| Ivy Strohmaier als Jessie |
 | Spencer Garrett als Willy |
 | Branden Williams als Teenage Boy |
 | Nate Richert als Other Teenage Boy |
| Cory Joffe als Customer |
| Dawn Saucier als Bartender |
 | Stacy Jorgensen als Lorraine's Pool Friend |
| Tennison Hightower als Baldasaro Salesgirl |
 | Lee Garlington als Jordan's Mom |
| John Srednicki als Premiere Guest |
| Jeremy Kramer als Premiere Photographer |
| Madeline Moskowitz als Premiere Guest |
 | Eric Winzenried als Parking Attendant |
| Greer Goodman als ER Doctor |
| Jerome Butler als Policeman |
 | Scott Adsit als Man at Phone |
| Ryan Wolfe als McDonald's Clerk |
| Alan Naggar als McDonald's Customer |
 | Elayn J. Taylor als Jane's Nurse |
| Nicole Holofcener | Director |
| Nicole Holofcener | Writer |
| Craig Richey | Original Music Composer |
| Harlan Bosmajian | Director of Photography |
| Robert Frazen | Editor |
| Jeanne McCarthy | Casting |
| Devorah Herbert | Production Design |
| Missy Parker | Art Direction |
| Vanessa Vogel | Costume Design |
| Anthony Bregman | Producer |
| Eric d'Arbeloff | Producer |
| Debra Grieco | Co-Producer |
| Ted Hope | Producer |
| Michael Kafka | Executive Producer |
| Jason Kliot | Executive Producer |
| Joana Vicente | Executive Producer |
| Charles J. Rusbasan | Co-Executive Producer |
| Judith Zarin | Co-Executive Producer |
| Michael Escott | Co-Executive Producer |
| Amy Rosen | Music Supervisor |
| Debra Grieco | Unit Production Manager |
| Van Hayden | First Assistant Director |
| Nicholas Lee | Second Assistant Director |
| Johnny D. Culley | Property Master |
| David Loitz | Leadman |
| Beth Steffen | Set Dresser |
| Sharon Curtis-Baltazar | Set Dresser |
| Derek Asuan-O'Brien | Set Dresser |
| Brad Morrison | Swing |
| Helen Caldwell | Script Supervisor |
| Cliff Hsui | First Assistant Camera |
| Daniella Gleeson | Second Assistant Camera |
| Jeff Woolley | Second Assistant Camera |
| Rory Muir | Second Assistant Camera |
| Kevin M. Andersen | Steadicam Operator |
| Eric Mas | Still Photographer |
| Alexia C. Pilat | Still Photographer |
| Brian Linder | Sound Mixer |
| Gerard Vernice | Boom Operator |
| David Palmieri | Best Boy Grip |
| Henry Coccetti | Gaffer |
| Mike Reppert | Best Boy Electric |
| George Gregory | Dolly Grip |
| Vince Palomino | Key Grip |
| Sean D. Flynn | Grip |
| John Berger | Grip |
| Samuel Hamilton | Grip |
| Richard D. Galbraith | Electrician |
| Michael Weeks | Electrician |
| Frank Jarnot | Electrician |
| Brett Smith | Electrician |
| Matt Petosa | Electrician |
| Praveena Paruchuri | Electrician |
| Brett Michael | Electrician |
| Ember Bekofsky | Costume Supervisor |
| Kathleen Freeman | Key Makeup Artist |
| Pecha Koyadinovich | Key Hair Stylist |
| John Blaine | Key Hair Stylist |
| Lana Milosavljevic | Assistant Hairstylist |
| Andrea Helm | Assistant Hairstylist |
| Alexis Walker | Assistant Makeup Artist |
| Kojo Lewis | Location Manager |
| Bess Carlisle Coleman | Assistant Location Manager |
| Brian Shafer | Assistant Location Manager |
| Diana Lui | Production Supervisor |
| Diana Lui | Production Coordinator |
| Julie Anne Adams | Production Accountant |
| Michael Caccamise | Assistant Production Coordinator |
| Kyle LeMire | Second Second Assistant Director |
| Tony Rasmussen | Extras Casting |
| John Srednicki | Casting Assistant |
| Nadia Lubbe Simon | Casting Assistant |
| Janice Gantenbein | Animal Wrangler |
| Steve Pate | Transportation Coordinator |
| Daniel Gabbe | Assistant Editor |
| Gary Coppola | Sound Re-Recording Mixer |
| Doug Davey | Sound Re-Recording Mixer |
| Kelly Oxford | Supervising Sound Editor |
| Craig Richey | Music Editor |
| Craig S. Jaeger | Foley Editor |
| Kimaree Long | Dialogue Editor |
