 | Danny Trejo als Machete Cortez |
 | Mel Gibson als Luther Voz |
 | Demián Bichir als Mendez |
 | Amber Heard als Blanca Vasquez / Miss San Antonio |
 | Michelle Rodriguez als Luz |
 | Sofía Vergara als Desdemona |
 | Charlie Sheen als Mr. President |
 | Jessica Alba als Sartana Rivera |
 | Lady Gaga als La Camaleon |
 | Alexa PenaVega als KillJoy |
 | Vanessa Hudgens als Cereza Desdemona |
 | Tom Savini als Osiris Amanpour |
 | Cuba Gooding Jr. als El Camaleon |
 | Antonio Banderas als El Camaleon |
 | Walton Goggins als El Camaleon |
 | William Sadler als Sheriff Doakes |
 | Marko Zaror als Zaror |
 | Julio Oscar Mechoso als Chepo |
 | Billy Blair als Billy |
 | Samuel Davis als Clebourne |
 | Felix Sabates als Doc Felix |
 | Electra Avellan als Nurse Mona |
 | Elise Avellan als Nurse Lisa |
| Marci Madison als Nurse Fine |
 | Callie Hernandez als Space Babe |
| Alejandro Antonio als Boss of Mendez |
 | Crystal Martinez als Wife of Mendez |
 | Corey Burton als Trailer Voice Guy (voice) |
 | Elon Musk als Elon Musk |
 | Emmy Robbin als Pris |
 | Jason Christopher als Lieutenant Brass |
 | Sam Medina als Cartel Leader |
 | J.J. Perry als Voz's Henchman (uncredited) |
 | Aleksander Rodnyansky als Radio Guest (uncredited) |
 | Vincent Fuentes als Cabrito Cook |
 | Elle LaMont als Dollface |
 | Jorge A. Jimenez als Dying Cartel Guy |
 | Cheech Marin als Padre |
| Robert Rodriguez | Director |
| Kyle Ward | Screenplay |
| Sergey Bespalov | Producer |
| Aaron Kaufman | Producer |
| Iliana Nikolic | Producer |
| Aleksander Rodnyansky | Producer |
| Rick Schwartz | Producer |
| Robert Rodriguez | Story |
| Robert Rodriguez | Producer |
| Robert Rodriguez | Original Music Composer |
| Robert Rodriguez | Editor |
| Robert Rodriguez | Director of Photography |
| Carl Thiel | Original Music Composer |
| Rebecca Rodriguez | Editor |
| Steve Joyner | Production Design |
| Mary Vernieu | Casting |
| Nina Proctor | Costume Design |
| Catherine Harper | Foley |
| Joe Rivera | Hairstylist |
| Mike McCutchen | Art Department Coordinator |
| Mike McCutchen | Set Decoration |
| Meredith Johns | Makeup Effects |
| Clark Crawford | Sound Designer |
| Paula Fairfield | Sound Designer |
| Angelo Palazzo | Sound Designer |
| Stuart Provine | Sound Effects Editor |
| Brad Engleking | Sound Re-Recording Mixer |
| Tim Rakoczy | Supervising Sound Editor |
| Joe Montenegro | Special Effects Coordinator |
| Troy Brown | Stunt Coordinator |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Sean Maxwell | Second Unit Cinematographer |
| P.K. Munson | Camera Operator |
| Matt Harshbarger | Steadicam Operator |
| Rico Torres | Still Photographer |
| Tony Aaron II | Additional Photography |
| Stephany Baskin | Set Costumer |
| Beatrice Bellino | Script Supervisor |
| Mark Edward Wright | Visual Effects Editor |
| Marcel Rodriguez | Story |
| Marina Bespalov | Associate Producer |
| Lindsey Graham | Casting |
| Alex Toader | Visual Effects Supervisor |
| Richard Gordoa | VFX Artist |
| Diana R. Lupo | Stunts |
| Jessica Harbeck | Stunts |
| Douglas Aarniokoski | Co-Producer |
| Jere Hausfater | Executive Producer |
| Sam Englebardt | Executive Producer |
| Paris Kasidokostas Latsis | Executive Producer |
| William D. Johnson | Executive Producer |
| Tom Proper | Co-Producer |
| Mark C. Manuel | Executive Producer |
| Boris Teterev | Executive Producer |
| Kelly Bellini | Stunts |
| David Alvarado | Stunts |
| Brian Brown | Stunts |
| Mark Chavarria | Stunts |
| Stacey Carino | Stunts |
| Laurence Chavez | Stunts |
| Nicholas Dashnaw | Stunts |
| Chad Dashnaw | Stunts |
| Eddie J. Fernandez | Stunts |
| Dick Hancock | Stunts |
| Paul Eliopoulos | Stunts |
| Joe Llanes | Stunts |
| Hans Marrero | Stunts |
| Norman Mora | Stunts |
| J.J. Perry | Stunts |
| Jeff Milburn | Stunt Driver |
| Rudy Reyes | Stunts |
| Dana Reed | Stunts |
| Freddie Poole | Stunts |
