 | Diego Luna als Manolo (voice) |
 | Channing Tatum als Joaquin (voice) |
 | Zoe Saldaña als Maria (voice) |
 | Christina Applegate als Mary Beth (voice) |
 | Eugenio Derbez als Chato (voice) |
 | Cheech Marin als Pancho Rodriguez (voice) |
 | Gabriel Iglesias als Pepe Rodriguez (voice) |
 | Ron Perlman als Xibalba (voice) |
 | Kate del Castillo als La Muerte (voice) |
 | Ana de la Reguera als Carmen Sánchez (voice) |
 | Dan Navarro als Chakal (voice) |
 | Ice Cube als Candle Maker (voice) |
 | Hector Elizondo als Carlos Sanchez (voice) |
 | Danny Trejo als Skeleton Luis (voice) |
 | Carlos Alazraqui als General Posada / Dali / Chuy (voice) |
 | Emil-Bastien Bouffard als Young Manolo (voice) |
 | Elijah Rodriguez als Young Joaquin |
| Genesis Ochoa als Young Maria (voice) |
 | Plácido Domingo als Skeleton Jorge (voice) |
 | Grey DeLisle als Grandmother (voice) (as Grey Griffin) |
| Trey Bumpass als Goth Kid / Orphan |
 | Miguel Sandoval als Land of the Remembered Captain (voice) |
 | Ben Gleib als Goya / Dali (voice) |
| Ricardo El Mandril Sanchez als Pablo Rodriguez (voice) |
| Ishan Sharma als Sanjay |
 | Jorge R. Gutierrez als Skeleton Carmelo (voice) |
 | Anjelah Johnson-Reyes als Adelita / Nina (voice) |
| Kennedy Peil als Sasha (voice) |
 | Sandra Equihua als Scardelita (voice) |
| Callahan Clark als Jane (voice) |
 | Gunnar Sizemore als Ignacio (voice) |
 | Angélica María als Sister Ana (voice) |
 | Eric Bauza als Father Domingo / Cave Guardian (voice) |
 | Aron Warner als Thomas (voice) |
 | Sandra Echeverría als Claudia (voice) |
 | Tonita Castro als La Muerte as Old Woman (voice) |
 | Troy Evans als Old Man Hemingway (voice) |
 | Guillermo del Toro als Land of the Remembered Captain's Wife (voice) |
 | Brad Booker als Conductor (voice) |
 | Rosemary Alexander als Additional Voices (voice) |
| Steve Alterman als Additional Voices (voice) |
 | Eva Bella als Additional Voices (voice) |
| Madison Carlon als Additional Voices (voice) |
 | Vicki Davis als Additional Voices (voice) |
 | Moosie Drier als Additional Voices (voice) |
 | Cullen McCarthy als Additional Voices (voice) |
 | David Michie als Additional Voices (voice) |
| Michelle Moores als Additional Voices (voice) |
 | Jonathan Nichols als Additional Voices (voice) |
 | Al Rodrigo als Additional Voices (voice) |
 | Marcelo Tubert als Additional Voices (voice) |
 | Lynnanne Zager als Additional Voices (voice) |
 | Ruth Zalduondo als Additional Voices (voice) |
 | Newell Alexander als Additional Voices (voice) |
 | Jose Alvarez als Additional Voices (voice) |
 | David Cowgill als Additional Voices (voice) |
 | Elisa Gabrielli als Additional Voices (voice) |
| Richard Miro als Additional Voices (voice) |
 | Arthur Ortiz als Additional Voices (voice) |
| Nathaniel Semsen als Additional Voices (voice) |
 | Joe Matthews als Young Manolo (singer) |
| Tyler DeLisle | Lighting Artist |
| Jorge R. Gutierrez | Director |
| Guillermo del Toro | Producer |
| Jorge R. Gutierrez | Writer |
| Andy Hass | Animation |
| Steve Cunningham | Animation |
| Devin Roth | Score Engineer |
| Dixie Pizani | Animation |
| Travis Tohill | Animation |
| Doug Langdale | Writer |
| Tom Caulfield | Character Designer |
| Gustavo Santaolalla | Original Music Composer |
| Ahren Shaw | Editor |
| Christian Kaplan | Casting |
| Simon Valdimir Varela | Production Design |
| Brad Booker | Producer |
| Carina Schulze | Producer |
| Keaton Kramer | Lighting Artist |
| Nick Shirsty | Lighting Artist |
| Jeff Carson | Music Editor |
| Beau Borders | Sound Re-Recording Mixer |
| Elise Hatheway | Visual Development |
| Frederick J. Gardner III | Visual Development |
| Aaron Berger | Producer |
| Naveen Syed | Animation |
| Allison Harbin | Animation Department Coordinator |
| Sing Khamnouane | Modeling |
| Andy Koyama | Sound Re-Recording Mixer |
| Jordan Lamarre-Wan | Visual Development |
| Geoffrey Stott | Co-Producer |
| Mark A. Mangini | Additional Sound Re-Recording Mixer |
| Michael Miller | ADR & Dubbing |
| Roy Latham | ADR & Dubbing |
| Angelo Sta. Catalina | Animation |
| David Mouser | Art Department Coordinator |
| Johnson Cheng | Assistant Editor |
| Glo Minaya | CG Supervisor |
| Blake Collins | Foley |
| Vitor Vilela | Lead Animator |
| Paul Sullivan | Art Direction |
| Shaun Freeman | Animation |
| Sylvain Deboissy | Character Designer |
| Ernesto Bottger | Lead Animator |
| Jason Petrocelli | Lead Animator |
| Billy Burson III | Lighting Artist |
| Connor McCampbell | Modeling |
| Tom M. Jordan | Modeling |
| Nicholas Bucknall | Musician |
| Roger Argente | Musician |
| Susie Bench | Orchestrator |
| Bridget Kieffer | Production Coordinator |
| Masanobu 'Tomi' Tomita | Sound Effects Editor |
| Connon Carey | VFX Artist |
| Will Nicholson | VFX Artist |
| Sarah Marino | Visual Development |
| Matthew Teevan | Co-Producer |
| Kathy Cavaiola | Production Manager |
| Jorge R. Gutierrez | Playback Singer |
| Julie Feiner | ADR Editor |
| Brad Faucheux | Animation |
| Emilie Goulet | Animation |
| Manuel Almela | Animation |
| Lea Kocurek | Animation Production Assistant |
| Jackie Koehler | Lead Animator |
| Daniel Guindi | Lighting Artist |
| Esther Parobek | Lighting Artist |
| Steve Mair | Musician |
| Andrew McTighe | Production Coordinator |
| Augusto Schillaci | VFX Supervisor |
| Cary Granat | Executive Producer |
| Greg Lyons | Associate Producer |
| Chris Street | Animation |
| Kathy Zielinski | Animation |
| Joseph R. Thygesen | Associate Editor |
| Mike Fortner | CG Supervisor |
| Dan O'Connell | Foley |
| John T. Cucci | Foley |
| Germaine Franco | Additional Music |
| William G. Parker | Additional Music |
| David B. Vallone | Animation |
| Ray Chase | Animation |
| Jake Albers | Compositors |
| Jess Morris | Lead Animator |
| N. Joseph Burnette | VFX Artist |
| Bryan Gregg LaShelle | Visual Development |
| Heather M. Drummons | Associate Producer |
| Luis Martinez | Animation |
| Matt Thurman | Animation |
| Morgan R. Kelly | Animation |
| Lino Cristofaro | Modeling |
| Eric Baker | Rigging Supervisor |
| Chris DiGiovanni | Associate Producer |
| Kathy Cavaiola | Production Supervisor |
| Don Dixon | Animation |
| Dorian Soto | Animation |
| Pete Paquette | Animation |
| Tod Polson | Conceptual Design |
| Todd Zongker | First Assistant Editor |
| Ed Whetstone | Lighting Artist |
| John Houlihan | Music Supervisor |
| Kyle Lawson | Production Coordinator |
| Casey Stone | Scoring Mixer |
| Andy King | Sound Re-Recording Mixer |
| Alberto Beguerie | Lighting Artist |
| Kevin Estrada | Still Photographer |
| Louis Jones | Supervising Animator |
| Ehsan Parizi | VFX Artist |
| Paul Sullivan | Production Design |
| Steven Liu | Additional Editing |
| Carlos Sotolongo | ADR & Dubbing |
| Travis Simon | Animation |
| Sandra Equihua | Character Designer |
| James Ashwill | Foley |
| Byron Slaybaugh | Lead Animator |
| Peter McCord | Lighting Artist |
| Thomas DesJardins | Lighting Artist |
| Julia Zuzanna Sokolowska | Orchestrator |
| Rick Giovinazzo | Orchestrator |
| Bill Haller | Supervising Animator |
| William Scott McCullough | Visual Effects |
| Rustam Hasanov | Visual Development |
| Ian McNeny | Assistant Editor |
| Andy Bialk | Character Designer |
| John Guentner | Foley |
| Garrett Moring | Lighting Artist |
| Kathleen Tran | Lighting Artist |
| James McWilliam | Orchestrator |
| Ryan Humphrey | Orchestrator |
| Jasmine Johnson | Production Manager |
| Katie Hasleham | Production Manager |
| Peter Zinda | Sound Effects Editor |
| Erich Turner | Special Effects Supervisor |
| Shu Liu | VFX Artist |
| Alexandre F. Kümpel | Animation |
| Andrew Ford | Animation |
| Amy Grieshaber | Associate Editor |
| Tiffany Renee Shreve | Continuity |
| Zara Park | Digital Intermediate |
| Paul Ohrt | Executive In Charge Of Production |
| Aron Warner | Executive Producer |
| Chris Garrick | Musician |
| Roger Linley | Musician |
| Anthony Fung | VFX Artist |
| Lorenzo Russell Bambino | Layout |
| Eric Drobile | Lead Animator |
| Kevin Lu | Compositors |
| Randall Manning | Lighting Artist |
| Charles Martin Inouye | Music Editor |
| Scott Wolf | Sound Effects Editor |
| Frank Pittenger | Sound Recordist |
| Nick Ilyin | VFX Artist |
| Nicholas Naugle | Lighting Artist |
| Jake Rusch | VFX Artist |
| Dustin D'Arnault | Visual Development |
| Ellyn Klein Golub | Visual Effects Coordinator |
| Rustam Hasanov | Conceptual Design |
| Gizem Gülen | Animation |
| Robert Lazzarini | Animation |
| Wing Ni Chung | Animation |
| Craig Price | Digital Intermediate |
| Liz Paradis | Modeling |
| Mark Berrow | Musician |
| Stephen P. Robinson | Sound Designer |
| Yashar Kassai | Visual Development |
| Jorge R. Gutierrez | Additional Music |
| Carlos Luzzi | Character Designer |
| Lori Williams | Compositors |
| Pete Herzog | Executive Producer |
| Michael Cacciamani | Lighting Artist |
| David Arch | Musician |
| Rachel Bolt | Musician |
| Jonas Thaler | Post Production Supervisor |
| Lara Blasingame | Production Accountant |
| Sean Ryan McEwan | Set Dressing Artist |
| Tim Walston | Sound Designer |
| Scott Martin Gershin | Supervising Sound Editor |
| Chas Naylor | VFX Artist |
| Chris Rasch | VFX Artist |
| Alison Donato | Visual Development |
| Shane Richardson | Visual Development |
| Chuck Peil | Executive Producer |
| Germaine Franco | Orchestrator |
| Christopher T. Welch | ADR Editor |
| Derek Esparza | Animation |
| Monica Aston | Animation |
| Robert Fox | Animation |
| Micah Dahlberg | Casting Associate |
| Jorge R. Gutierrez | Character Designer |
| Tim Davies | Conductor |
| Lilly Sechrist | Editorial Coordinator |
| Jessie Pariseau | First Assistant Sound Editor |
| Eric Burnett | Lead Animator |
| Robyn Ducharme | Lighting Artist |
| Elias Glasch | Modeling |
| Ryan Trammell | Modeling |
| Rob Thomson | Production Coordinator |
| Jesse Johnstone | Sound Recordist |
| T.J. Callaway | Temp Sound Editor |
| Travis Koller | Visual Development |
