 | Guy Pearce als Leonard |
 | Carrie-Anne Moss als Natalie |
 | Joe Pantoliano als Teddy |
 | Mark Boone Junior als Burt |
 | Russ Fega als Waiter |
 | Jorja Fox als Leonard's Wife |
 | Stephen Tobolowsky als Sammy Jankis |
 | Harriet Sansom Harris als Mrs. Jankis |
 | Thomas Lennon als Doctor |
 | Callum Keith Rennie als Dodd |
 | Kimberly Campbell als Blonde |
 | Marianne Muellerleile als Tattooist |
 | Larry Holden als Jimmy |
| David Julyan | Original Music Composer |
| Wally Pfister | Director of Photography |
| Richard LeGrand Jr. | Supervising Sound Editor |
| John Papsidera | Casting |
| Aaron Ryder | Executive Producer |
| Patti Podesta | Production Design |
| Dody Dorn | Editor |
| Christopher Nolan | Screenplay |
| Jennifer Todd | Producer |
| Suzanne Todd | Producer |
| Mikael Sandgren | Music Editor |
| Julius LeFlore | Stunt Coordinator |
| Steve Gehrke | Script Supervisor |
| Christopher Ball | Co-Executive Producer |
| David Klotz | Music Supervisor |
| Emma Thomas | Associate Producer |
| William Tyrer | Co-Executive Producer |
| Cindy Evans | Costume Design |
| Danielle Berman | Set Decoration |
| Page Rosenberg-Marvin | Unit Production Manager |
| Jenifer Chatfield | Post Production Supervisor |
| Elaine Dysinger | Co-Producer |
| Lawrence Lewis | Production Coordinator |
| Russ Fega | Location Manager |
| Wendy O'Brien | Casting Assistant |
| Terrence Harris | Casting Associate |
| Christopher Nolan | Director |
| Scott H. Eddo | Key Makeup Artist |
| Larry Waggoner | Key Hair Stylist |
| Chris Edmonds | First Assistant Director |
| Annie Laoparadonchai | Set Costumer |
| Laura Marolakos | Assistant Costume Designer |
| Bob Hall | Camera Operator |
| William Hooper | Sound Effects Editor |
| Gary S. Gerlich | Supervising Sound Editor |
| Patrick O'Sullivan | Sound Effects Editor |
| Walter Spencer | Dialogue Editor |
| Jonathan Wales | Sound Re-Recording Mixer |
| Jonathan Nolan | Short Story |
| Jonathan Nolan | Story |
| Corey Michael Eubanks | Stunts |
