 | Mira Sorvino als Susan Tyler |
 | Jeremy Northam als Peter Mann |
 | Alexander Goodwin als Chuy |
 | Giancarlo Giannini als Manny |
 | Charles S. Dutton als Leonard |
 | Josh Brolin als Josh |
 | Alix Koromzay als Remy |
 | F. Murray Abraham als Dr. Gates |
 | James Costa als Ricky |
 | Javon Barnwell als Davis |
 | Norman Reedus als Jeremy |
 | Ho Pak-Kwong als Preacher |
 | Glenn Bang als Yang |
| Margaret Ma als Chinese Woman |
| Warna Fisher als Bag Lady |
| Alan Argue als Skeletal Bum |
| Charles Hayter als Homeless Man |
 | Julian Richings als Workman |
 | James Kidnie als Subway Repairman |
| Eve English als Homeless Woman |
| Bill Lasovich als Long John |
 | Doug Jones als Long John |
| Roger Clown als Long John |
 | Greg Bronson als Reporter (uncredited) |
| Guillermo del Toro | Screenplay |
| B.J. Rack | Producer |
| Dan Laustsen | Director of Photography |
| Billy Hopkins | Casting |
| Ole Bornedal | Producer |
| Suzanne Smith Crowley | Casting |
| Bob Weinstein | Producer |
| Patrick Lussier | Editor |
| Marco Beltrami | Original Music Composer |
| Peter Devaney Flanagan | Editor |
| Kerry Barden | Casting |
| Guillermo del Toro | Director |
| Matthew Robbins | Screenplay |
| Marie-Sylvie Deveau | Costume Design |
| Bob Munroe | Animation Director |
| Al Broussard | Special Effects Coordinator |
| Carol Spier | Production Design |
| Elinor Rose Galbraith | Set Decoration |
| Cyndi Ochs | Art Department Coordinator |
| Tamara Deverell | Art Direction |
| Bob Kensinger | Set Decoration |
| John Casey | Costume Supervisor |
| Dug Rotstein | Script Supervisor |
| Donald Mowat | Makeup Department Head |
| Harvey Weinstein | Co-Executive Producer |
| Donald A. Wollheim | Short Story |
| Michael Phillips | Executive Producer |
| Andrew Rona | Co-Producer |
| Cary Granat | Co-Producer |
| Scott Shiffman | Co-Producer |
| Richard Potter | Co-Producer |
| Guillermo del Toro | Screenstory |
| Stuart Cornfeld | Co-Executive Producer |
| Michael Zoumas | Co-Producer |
| Clark Henderson | Associate Producer |
| Matthew Robbins | Screenstory |
| Rob Bottin | Creature Design |
| Dennis Chapman | Unit Production Manager |
| Branko Racki | Stunt Coordinator |
| Kerry Hayes | Still Photographer |
| Bryan Forde | Gaffer |
| Mike Kirilenko | Key Grip |
| Candide Franklyn | Dolly Grip |
| Glen Gauthier | Sound Recordist |
| Steve Switzer | Boom Operator |
| Jeff J.J. Authors | Second Unit Director |
| Rick Bota | Second Unit Director |
| Robert Rodriguez | Second Unit Director |
| Brian Jennings | Visual Effects Supervisor |
| Colin Cunningham | Visual Effects |
| Shelley Cook | Stunts |
| Doug Coleman | Stunts |
| Mark Griffith | Digital Intermediate Colorist |
| Dan Bradley | Stunt Coordinator |
| Eric Chambers | Stunts |
| John Sayles | Additional Writing |
| Kathy Jarvis | Stunt Double |
