 | Tara Strong als Twilight Sparkle (voice) |
 | Ashleigh Ball als Applejack / Rainbow Dash (voice) |
 | Andrea Libman als Pinkie Pie / Fluttershy (voice) |
 | Tabitha St. Germain als Rarity / Princess Luna / Granny Smith / Derpy Hooves (voice) |
 | Cathy Weseluck als Spike (voice) |
 | Emily Blunt als Tempest Shadow / Fizzlepop Berrytwist (voice) |
 | Michael Peña als Grubber (voice) |
 | Liev Schreiber als The Storm King (voice) |
 | Taye Diggs als Capper (voice) |
 | Zoe Saldaña als Captain Celaeno (voice) |
 | Kristin Chenoweth als Princess Skystar (voice) |
 | Uzo Aduba als Queen Novo (voice) |
 | Sia als Songbird Serenade (voice) |
 | Rebecca Shoichet als Twilight Sparkle (singing voice) |
 | Shannon Chan-Kent als Pinkie Pie (singing voice) |
 | Kazumi Evans als Rarity (singing voice) |
 | Mark Oliver als First Mate Mullet (voice) |
 | Max Martini als Boyle (voice) |
 | Adam Bengis als Code Red (voice) |
 | Nicole Oliver als Princess Celestia / Lix Spittle (voice) |
 | Britt McKillip als Princess Cadance (voice) |
 | Brian Dobson als Verko (voice) |
 | Peter New als Big McIntosh (voice) |
 | Michelle Creber als Apple Bloom (voice) |
 | Michael Dobson als Bulk Biceps (voice) |
 | Sam Vincent als Party Favor (voice) |
| Stephen Davis | Producer |
| Brian Goldner | Producer |
| Jayson Thiessen | Director |
| Michael Vogel | Co-Executive Producer |
| Meghan McCarthy | Co-Executive Producer |
| Sarah Wall | Executive Producer |
| Marcia Gwendolyn Jones | Producer |
| Haven Alexander | Producer |
| Anthony Di Ninno | Director of Photography |
| Kirsten Newlands | Executive Producer |
| Michel Gagné | VFX Artist |
| Rebecca Dart | Art Direction |
| Kevin Munroe | Creative Consultant |
| Josh Feldman | Executive Producer |
| Joe Ballarini | Story |
| Tobias Anker | VFX Supervisor |
| Braden Oberson | Editor |
| Lauren Faust | Characters |
| Meghan McCarthy | Story |
| Meghan McCarthy | Screenplay |
| Michael Vogel | Screenplay |
| Rita Hsiao | Screenplay |
| Hideki Hamasu | Animation |
| Flávia Guttler | Animation Supervisor |
| Felipe Molica | Key Animation |
| Duan Nanhao | Key Animation |
| Adam Arsenault | Animation Supervisor |
| Daniel Ingram | Original Music Composer |
| Daniel Ingram | Songs |
