 | Amy Gumenick als Natalee Holloway |
 | Tracy Pollan als Beth Holloway-Twitty |
 | Grant Show als Jug Twitty |
 | Catherine Dent als Carol |
 | Natasha Loring als Hayley |
 | Jacques Strydom als Joran Van Der Sloot |
| Kim Senogles als Justine |
| Erin Cloytier als Darla |
 | Clayton Evertson als Deepak Kalpoe |
 | Hein De Vries als Satish Kalpoe |
 | Julie Summers als Barbara Waxman |
 | Cokey Falkow als Patrick van Eem |
| Leigh Bremridge als Diana Peterson |
 | Susan Danford als Maggie |
 | Sean Cameron Michael als Paul van der Sloot |
| Sean Higgs als Detective Frank Sneider |
 | André Jacobs als Detective Roemer |
 | Bjorn Steinbach als Brent |
| Wayne Harrison als Dave Holloway |
| Mikael Salomon | Director |
| Beth Holloway-Twitty | Novel |
| Teena Booth | Teleplay |
| Mikael Salomon | Co-Executive Producer |
| Andrew Golov | Producer |
| Marvin Saven | Co-Producer |
| Genevieve Hofmeyr | Supervising Producer |
| Judith Verno | Executive Producer |
| Frank von Zerneck | Executive Producer |
| Robert M. Sertner | Executive Producer |
| Paul Gilpin | Director of Photography |
| Christopher Ward | Music |
| Susan Bluestein | Casting |
| Sidney Wolinsky | Editor |
| Diana Cilliers | Costume Design |
| Riccardo Pugliese | Production Design |
| Kerry Skelton | Key Hair Stylist |
| Megan Tanner | Makeup Department Head |
| Dylan Voogt | Production Supervisor |
| Greig Buckle | Unit Production Manager |
| David B. Cohn | Sound Supervisor |
| Derek Mansvelt | Production Sound Mixer |
| Derek Marcil | Sound Re-Recording Mixer |
| Nello Torri | Sound Re-Recording Mixer |
| Mark Petersen | Sound Effects Editor |
| Jeff Gross | Foley Mixer |
| Lorita de la Cerna | Foley Recordist |
| Lorita de la Cerna | Foley Editor |
| Kevin Nanaumi | Assistant Sound Editor |
| David Vána | Visual Effects Supervisor |
| Michal Teprik | Visual Effects Coordinator |
| Vladimir Valovic | Digital Compositor |
| Lenka Líkařová | Visual Effects Producer |
| John McKay | Gaffer |
| Peter Belcher | Camera Operator |
| Sarel Pretorius | "B" Camera Operator |
| Sarel Pretorius | Steadicam Operator |
| Anna Feyder | Casting |
| Leonie Roberts | Costume Supervisor |
| Richard J. Rossi | Assistant Editor |
| Joe Paganelli | Music Coordinator |
| Jeff Lingle | Music Editor |
| Terry Fletcher | Script Supervisor |
| Jon-Luke Lourens | First Assistant Director |
| Christo van Schalkwyk | Second Assistant Director |
