 | Paz de la Huerta als Abby Russell |
 | Katrina Bowden als Danni Rogers |
 | Judd Nelson als Dr. Robert Morris |
 | Corbin Bleu als Steve |
 | Boris Kodjoe als Detective Rogan |
 | Melanie Scrofano als Rachel Adams |
 | Niecy Nash als Regina |
 | Martin Donovan als Larry Cook |
 | Chris Hoffman als Married Man / Fred |
 | Brittany Adams als Young Nurse |
 | Kathleen Turner als Head Nurse |
 | Jake Michaels als New Dad |
 | Adam Herschman als Jared |
 | Patrick Kwok-Choon als EMT #1 |
| Tracy Michailidis als Abby's Mom |
 | Jeff Pangman als Dr. Robert Price |
| Elyse Mason als Pretty Young Nurse |
| Dr. Linda Papadopoulos als Danni's Mom (Marcia) |
| Milan Carmona als Hispanic Kid |
 | Kate Maxx als Nurse Hansen |
 | Kjartan Hewitt als Orderly |
| Gregory Dunham als Urine Bag Patient |
 | David Huband als Detective Goldberg |
| Lori Pearlstein als Support Speaker |
 | Michael Eklund als Richie |
| Katia Peel als Young Abby (5 years) |
 | Landy Cannon als Hawaiian Shirt Guy |
 | Joe MacLeod als EMT #2 |
 | Layton Morrison als Truck Driver |
| Amanda Armagon als Receptionist |
 | Michael Therriault als Anatomy Professor |
 | Lauro Chartrand als Security Guard |
 | Stephan Dubeau als Doctor |
| Adam Richard Benish als Peter Larson (uncredited) |
 | Yulia Lukin als Larry's Date (uncredited) |
 | Blake Mawson als Bloody Boyfriend on Stretcher (uncredited) |
| Marc Andrew Smith als Doctor (uncredited) |
| Douglas Aarniokoski | Director |
| Boris Mojsovski | Director of Photography |
| Andrew Coutts | Editor |
| John Sacchi | Executive Producer |
| Marc Bienstock | Producer |
| Zaldy | Costume Design |
| Douglas Aarniokoski | Screenplay |
| Anton Sanko | Original Music Composer |
| Alicia Keywan | Production Design |
| Edward Bonutto | Art Direction |
| Nigel Hutchins | Set Decoration |
| Tim Mogg | Makeup Department Head |
| Summer Gaal | Set Dresser |
| Glenn T. Morgan | Supervising Sound Editor |
| Ben Wilkins | Sound Re-Recording Mixer |
| Ben Wilkins | Foley Supervisor |
| Jon Campfens | Visual Effects Supervisor |
| Peter Denomme | Visual Effects Producer |
| Jeffrey Kalmus | Visual Effects Supervisor |
| Martin López Funes | Visual Effects Producer |
| Pravina Sippy | Visual Effects Producer |
| Melissa Stewart | Set Costumer |
| David Loughery | Screenplay |
| Janene Carleton | Stunt Double |
| Lauro Chartrand | Stunts |
| Graham Chivers | Makeup Effects |
| Allan Cooke | Makeup Effects |
| Steven Dawley | Makeup Effects |
| Verity Fiction | Makeup Artist |
| Rose-Mary Holosko | Hairstylist |
| Paul Jones | Makeup Effects Designer |
| Zane Knisely | Makeup Effects |
| Steven Kostanski | Makeup Effects |
| Daniel Losco | Hairstylist |
| Emily Skoggard | Makeup Effects |
| Samantha Terry | Hairstylist |
| Devon Ellis | Makeup Effects |
| David Rimer | First Assistant Director |
| Greg Sigurdson | Third Assistant Director |
| Matt Dawson | ADR Mixer |
| Patrick Despain | Sound Re-Recording Mixer |
| Paul Flinchbaugh | First Assistant Sound Editor |
| Shawn Hook-Carleton | Sound |
| Michael Miller | ADR Mixer |
| Glenn T. Morgan | Sound Designer |
| Erika Schengili-Roberts | Sound Mixer |
| John J. Thomson | Sound Mixer |
| Daniel White | Special Effects |
| Pablo José Fuertes | Visual Effects |
| Ashley Hydrick | Visual Effects |
| Tim LeDoux | Visual Effects |
| Martin López Funes | Visual Effects |
| Jason Sanford | Visual Effects |
| Pravina Sippy | Visual Effects |
| Lloyd Adams | Stunts |
| Nick Alachiotis | Stunts |
| Marco Bianco | Stunts |
| Sharon Canovas | Stunts |
| Brett Chan | Stunts |
| Bernadette Couture | Stunts |
| Joel Harris | Stunts |
| Susan Horton | Stunts |
| Brayden Jones | Stunts |
| Riley Jones | Stunts |
| Brian Kaulback | Stunts |
| Liise Keeling | Stunts |
| Karen Leach | Stunts |
| Layton Morrison | Stunt Coordinator |
| Aj Risi | Stunts |
| Alicia Turner | Stunts |
