 | John Malkovich als Lennie Small |
 | Gary Sinise als George Milton |
 | Ray Walston als Candy |
 | Casey Siemaszko als Curley |
 | Sherilyn Fenn als Curley's Wife |
 | John Terry als Slim |
 | Richard Riehle als Carlson |
 | Alexis Arquette als Whitt |
 | Joe Morton als Crooks |
 | Noble Willingham als The Boss |
 | Joe D'Angerio als Jack |
 | Tuck Milligan als Mike |
 | David Steen als Tom |
 | Moira Sinise als Girl in Red Dress |
 | Mark Boone Junior als Bus Driver |
| Robert L. Sinise | Editor |
| John Steinbeck | Novel |
| Kenneth MacMillan | Director of Photography |
| Horton Foote | Screenplay |
| Gary Sinise | Director |
| Alan C. Blomquist | Executive Producer |
| Mark Isham | Original Music Composer |
| Russell Smith | Producer |
| Gary Sinise | Producer |
| Alan C. Blomquist | Unit Production Manager |
| Cara Giallanza | First Assistant Director |
| Michele Panelli-Venetis | Second Assistant Director |
| Dan Davis | Art Direction |
| Karen Schulz Gropman | Set Decoration |
| Joyce Anne Gilstrap | Set Decoration |
| Bonita DeHaven | Makeup Artist |
| Fríða Aradóttir | Key Hair Stylist |
| Ann Pala | Assistant Makeup Artist |
| Peggy Hannaman | Assistant Hairstylist |
| John Phillips | Supervising Sound Editor |
| Bill Phillips | Supervising Sound Editor |
| Howard Jensen | Special Effects |
| Charles Croughwell | Stunt Coordinator |
