 | Megan Fox als April O'Neil |
 | Will Arnett als Vernon Fenwick |
 | Laura Linney als Chief Vincent |
 | Stephen Amell als Casey Jones |
 | Noel Fisher als Michelangelo |
 | Jeremy Howard als Donatello |
 | Pete Ploszek als Leonardo |
 | Alan Ritchson als Raphael |
 | Tyler Perry als Baxter Stockman |
 | Brian Tee als Shredder |
 | Gary Anthony Williams als Bebop |
 | Stephen Farrelly als Rocksteady |
 | Peter Donald Badalamenti II als Splinter |
 | Tony Shalhoub als Splinter (voice) |
 | Brad Garrett als Krang (voice) |
 | Opal Alladin als Security Officer |
 | Brittany Ishibashi als Karai |
 | Connor Fox als Trevor |
 | Alessandra Ambrosio als Self |
 | Stan Demidoff als Uniformed Cop |
| Jill Martin als Self |
 | Greg Hildreth als Security Guard |
 | Dean Winters als Bartender |
 | Antoinette Kalaj als Hostess |
 | Alice Callahan als Attractive Detective |
 | Jane Wu als Jade |
| Steve Lacy als News Anchor |
 | Carmelo Anthony als Self |
 | DeAndre Jordan als Self |
 | JJ Redick als Self |
 | Matt Barnes als Self |
 | Austin Rivers als Self |
| Langston Arnold Galloway als Self |
| Shane Larkin als Self |
 | Lou Amundson als Self |
| Andrea Bargnani als Self |
| Quincy Acy als Self |
| Courtney L. Kirkland als Referee |
| Justin Van Duyne als Referee |
| Joslyn Brewster als Bumbleebee |
 | Robert Clohessy als Deputy Warden Hamlett |
 | Alexis Suarez als Officer |
 | John Palladino als Officer |
 | Meredith Travers als Schoolgirl |
| Edwin J. Birmingham als NYPD ESU |
 | Paul Teutul, Jr. als Corrections Officer |
 | Kevin Eastman als Pizza Delivery Guy |
| Dave Green | Director |
| Josh Appelbaum | Writer |
| André Nemec | Writer |
| Peter Laird | Characters |
| Kevin Eastman | Characters |
| Michael Bay | Producer |
| Andrew Form | Producer |
| Bradley Fuller | Producer |
| Galen Walker | Producer |
| Scott Mednick | Producer |
| Denis L. Stewart | Executive Producer |
| Grant Curtis | Executive Producer |
| Eric J. Crown | Executive Producer |
| Napoleon Smith III | Executive Producer |
| Josh Appelbaum | Executive Producer |
| André Nemec | Executive Producer |
| Lula Carvalho | Director of Photography |
| Martin Laing | Production Design |
| Jim May | Editor |
| Debra Neil-Fisher | Editor |
| Bob Ducsay | Editor |
| Sarah Edwards | Costume Designer |
| Steve Jablonsky | Original Music Composer |
| Pablo Helman | Visual Effects Supervisor |
| Lisa Fields | Casting |
| Basil Grillo | Unit Production Manager |
| Denis L. Stewart | Unit Production Manager |
| Alexander H. Gayner | First Assistant Director |
| Deanna Leslie | Second Assistant Director |
| Spiro Razatos | Second Unit Director |
| Spiro Razatos | Stunt Coordinator |
| Crystal Dowd | Visual Effects Producer |
| Susan Greenhow | Visual Effects Producer |
| Kevin Martel | Animation Supervisor |
| Robert Weaver | Visual Effects Supervisor |
| Jason W. Jennings | Supervising Sound Editor |
| Nancy Nugent | Supervising Sound Editor |
| Terry Porter | Sound Re-Recording Mixer |
| Anna Behlmer | Sound Re-Recording Mixer |
| Jonathan Eusebio | Stunt Coordinator |
| Alex Anagnostidis | Stunts |
| Joe Bucaro III | Stunts |
| Richard Augusto Burgos | Stunts |
| Chris Cenatiempo | Stunts |
| Kevin Chase | Stunts |
| Anis Cheurfa | Stunts |
| George B. Colucci Jr. | Stunts |
| Phil Culotta | Stunts |
| Kachina Dechert | Stunts |
| Tim Drnec | Stunts |
| Matt Emig | Stunts |
| Danny Graham | Stunts |
| Daniel Hernandez | Stunts |
| Don Hewitt Jr. | Stunts |
| Micah Karns | Stunts |
| Keone Kim | Stunts |
| Henry Kingi | Stunts |
| Paul M. Lane | Stunts |
| Oakley Lehman | Stunts |
| Jalil Jay Lynch | Stunts |
| Brian Machleit | Stunts |
| Angela Meryl | Stunts |
| Rocco Muniz | Stunts |
| Jim Ng | Stunts |
| Denney Pierce | Stunts |
| Jimmy N. Roberts | Stunts |
| Kevin Rogers | Stunts |
| Mike Ryan | Stunts |
| Brian Smyj | Stunts |
| Justin Sundquist | Stunts |
| Lori Scowley | Associate Producer |
| Lori Scowley | Production Controller |
| Basil Grillo | Associate Producer |
| Bret Rowe | Associate Producer |
| Marc Pappalardo | Associate Producer |
| Miguel López-Castillo | Art Direction |
| Debra Schutt | Set Decoration |
| Matthew Moriarty | "A" Camera Operator |
| Matthew Moriarty | Steadicam Operator |
| Tim Norman | "B" Camera Operator |
| Bobby Mancuso | First Assistant Camera |
| Scott Tinsley | First Assistant Camera |
| Chris Silano | First Assistant Camera |
| Anthony Coan | Second Assistant Camera |
| Andrew Nelson | Second Assistant Camera |
| Troy Sola | Second Assistant Camera |
| Justin Mancuso | Camera Loader |
| Connie Huang | Camera Loader |
| Nicholas Kay | Digital Imaging Technician |
| Patrick Capone | Additional Director of Photography |
| Jack Donnelly | Additional Director of Photography |
| John Oliveri | Additional First Assistant Camera |
| Robert Strait | Digital Imaging Technician |
| Deirdre Horgan | Script Supervisor |
| Tom Nelson | Sound Mixer |
| Peter Fonda | Sound Mixer |
| Frank Graziadei | Boom Operator |
| Brady Nelson | Boom Operator |
| Brady Nelson | Cableman |
| John Gutierrez | Boom Operator |
| Jay Fortune | Chief Lighting Technician |
| Brian McClean | Assistant Chief Lighting Technician |
| Kenneth Potter | Lighting Technician |
| Jeffrey Hinnes | Lighting Technician |
| Ben Ng | Lighting Technician |
| Patrick Lynch | Lighting Technician |
| Glenn Heap | Lighting Technician |
| Tom Prate | First Company Grip |
| Steven R. Paquette | Second Company Grip |
| Brandon Malone | Dolly Grip |
| Gregory M. Dressel | Dolly Grip |
| Todd Giresi | Grip |
| Brendan Lowry | Grip |
| Joaquin E. Padilla | Grip |
| Kevin Hughes | Grip |
| Gavin Holmes Jr. | Grip |
| Shaun Patrick Lowry | Rigging Grip |
| Douglas Kennedy | Rigging Grip |
| Paul Grunke | Rigging Grip |
| Michael Norman Buck | Techno Crane Operator |
| J.D. Schwalm | Special Effects Supervisor |
| Jim Schwalm | Special Effects Coordinator |
| Nathaniel Acord | Special Effects Technician |
| Sean Amborn | Special Effects Technician |
| Conrad V. Brink Jr. | Special Effects Technician |
| Greg Bryant | Special Effects Technician |
| Jeremiah Cooke | Special Effects Technician |
| Mike Derry | Special Effects Technician |
| David Eland | Special Effects Technician |
| Nathanael Brotherhood | Special Effects Technician |
| Doug Facciponti | Special Effects Technician |
| Roland Fullajtar | Special Effects Technician |
| Shane Gross | Special Effects Technician |
| Raymond Hoffman | Special Effects Technician |
| Eric Jolley | Special Effects Technician |
| David K. Lieber III | Special Effects Technician |
| Aleksandr Lokensgard | Special Effects Technician |
| Mike Maggi | Special Effects Technician |
| Robert H. Paquette | Special Effects Technician |
| Daniel Slavin | Special Effects Technician |
| Charles R. Simunek | Special Effects Technician |
| Matthew Wilson | Special Effects Technician |
| Jim Bilz | Pyrotechnician |
| Nils Widboom | Location Manager |
| Mara Alcaly | Assistant Location Manager |
| Robert Noonan | Assistant Location Manager |
| Jamie Vermilye | Assistant Location Manager |
| Diana Burton | Property Master |
| David Schanker | Assistant Property Master |
| Sarah Dennis | Assistant Set Decoration |
| Lisa Scoppa | Set Decoration Buyer |
| Paul Cheponis | Set Decoration Buyer |
| Philip Canfield | Leadman |
| Tina Khayat | Set Decorating Coordinator |
| Patrice Canfield Longo | Set Dresser |
| Richard K. Hoppe | Set Dresser |
| Michael Bruno | Set Dresser |
| Debbie Canfield | Set Dresser |
| Damon Hahn | Set Dresser |
| Tim Zydel | Set Dresser |
| Casey Devlin | Set Dresser |
| Teresa Kelly Canfield | Set Dresser |
| Jim Cook | Set Dresser |
| Tom Tamborello | Set Dresser |
| Arianna Gallo | Assistant Costume Designer |
| Kate Edwards | Costume Supervisor |
| Kathleen Gerlach | Costume Supervisor |
| Winsome G. McKoy | Costume Supervisor |
| Kimmie Guiragossian | Costumer |
| Sandi Figueroa | Costumer |
| Jessica Chaney | Costumer |
| Kathleen St. John | Costumer |
| Danielle Cadorette | Tailor |
| John Caglione Jr. | Makeup Department Head |
| Eve Morrow | Key Makeup Artist |
| Josh Turi | Special Effects Makeup Artist |
| Angela Levin | Makeup Artist |
| Wanda Patterson | Makeup Artist |
| Jasen Joseph Sica | Hair Department Head |
| Gary Martori | Key Hair Stylist |
| Byron Johnson | Hairstylist |
| Debra L. Tennant | First Assistant Editor |
| Sam Bollinger | First Assistant Editor |
| Jamie Clarke | Assistant Editor |
| Christian Sharaf | Assistant Editor |
| David S. Clark | Assistant Editor |
| Maria Gonzales | Assistant Editor |
| Greg Thompson | Assistant Editor |
| Stephanie Coats | Post Production Assistant |
| Ray Bushey III | Visual Effects Editor |
| Ron San Agustin | Visual Effects Assistant Editor |
| Kevin LaNeave | Visual Effects Assistant Editor |
| John Naclerio | Production Supervisor |
| John DeSimone | Production Supervisor |
| Daren Hicks | Production Supervisor |
| Shima Majidi | Assistant Production Coordinator |
| John Moskowitz | Script Coordinator |
| Woodrow Travers | Second Second Assistant Director |
| Luca Waldman | Second Second Assistant Director |
| Joseph Landry | Additional Second Assistant Director |
| Alex Scricco | Additional Second Assistant Director |
| Stephen E. Hagen | First Assistant Director |
| Anna Olshansky | Second Assistant Director |
| John McKenna Jr. | Second Second Assistant Director |
| Peter Dorsey | Assistant Art Director |
| Aimee Dombo Desmond | Assistant Art Director |
| Jeannette Kim | Assistant Art Director |
| Michael Auszura | Assistant Art Director |
| Jeffrey D. McDonald | Assistant Art Director |
| Gregory Hill | Graphic Designer |
| Miriam Schapiro | Art Department Coordinator |
| David Lowery | Storyboard Artist |
| Mark Vena | Storyboard Artist |
| Todd Harris | Storyboard Artist |
| Tony Liberatore | Storyboard Artist |
| Phil Langone | Storyboard Artist |
| Dan Sweetman | Storyboard Artist |
| John Barba | Casting Associate |
| Karina Walters | Casting Associate |
| Kathleen Chopin | Casting |
| Chad Eric Murnane | Casting Assistant |
| Anne Davison | Casting Associate |
| Jessica Miglio | Still Photographer |
| Marcus Taormina | Visual Effects Production Manager |
| Nick Irving Allen | Visual Effects Coordinator |
| Skylar Nichols | Visual Effects Coordinator |
| Melissa Franco | Visual Effects Coordinator |
| Scott Gastellu | Compositing Artist |
| Nina Harlan | Compositing Artist |
| Chance Tanner | 3D Coordinator |
| Michael Hertlein | Dialogue Editor |
| Renée Tondelli | ADR Editor |
| John C. Stuver | ADR Editor |
| Kira Roessler | ADR Editor |
| Anna MacKenzie | ADR Editor |
| John Marquis | Sound Designer |
| John Marquis | Sound Effects Editor |
| Chris Terhune | Sound Effects Editor |
| Chris Diebold | Sound Effects Editor |
| Joel Erickson | Sound Effects Editor |
| Malte Bieler | Sound Effects Editor |
| Dan O'Connell | Foley Artist |
| John T. Cucci | Foley Artist |
| James Ashwill | Foley Mixer |
| Richard Duarte | Foley Mixer |
| Jack Cucci | Foley Mixer |
| Alicia Stevenson | Foley Artist |
| Dawn Fintor | Foley Artist |
| David Jobe | Foley Mixer |
| Judah Getz | ADR Mixer |
| Vicki Lemar | ADR Mixer |
| Michael Miller | ADR Mixer |
| Barbara Harris | ADR Voice Casting |
| Alex Gibson | Supervising Music Editor |
| Kevin McKeever | Music Editor |
| David Fleming | Additional Music |
| Gary Dworetsky | Additional Music |
| Jay Flood | Additional Music |
| Corey Allen Jackson | Additional Music |
| Kenneth Nelson | Construction Coordinator |
| Wendy Williams | Unit Production Manager |
| Jacques Haitkin | Second Unit Director of Photography |
| James LaRocca | Second Unit First Assistant Director |
| Ken C. Wu | Second Assistant Director |
| Onofrio Nino Pansini | "A" Camera Operator |
| Henry Tirl | "B" Camera Operator |
| Daniel Nichols | "C" Camera Operator |
| Greg Luntzel | First Assistant Camera |
| Robert M. Sagaser | First Assistant Camera |
| Todd Schlopy | First Assistant Camera |
| Ethan Borsuk | First Assistant Camera |
| Symon Mink | First Assistant Camera |
| Stephen Wong | First Assistant Camera |
| Eve Strickman | Second Assistant Camera |
| Matt Fortlage | Second Assistant Camera |
| Terry Wolcott | Second Assistant Camera |
| Brendan K. Russell | Second Assistant Camera |
| Brett Roedel | Second Assistant Camera |
| Abdelkarim Belkasemi | Camera Loader |
| Dave Satin | Digital Imaging Technician |
| Veronica Lupu | Script Supervisor |
| James A. Dolan | Chief Lighting Technician |
| Kane Delaney | Assistant Chief Lighting Technician |
| David L. Kissinger II | Lighting Technician |
| Michael Mortell | Lighting Technician |
| Peter Bulavinetz | First Company Grip |
| Peter Chrimes | First Company Grip |
| Robbin Park | Second Company Grip |
| Rob Harlow | Dolly Grip |
| Dylan Crawshay-Williams | Grip |
| Abraham Altbuch | Grip |
| David Ganczewski | Grip |
| Craig William Catolane | Grip |
| Matthew Farrell | Grip |
| Timothy Limner | Rigging Grip |
| David Gray | Rigging Grip |
| Manuel Abad III | Rigging Grip |
| Katherine Glendenning | Rigging Grip |
| Rafael Lima | Location Manager |
| Corri Hopkins | Assistant Location Manager |
| Gail A. Fitzgibbons | Costume Supervisor |
| Thomas M. Smalley | Costumer |
| Billie Jo Fisher | Costumer |
| Debbie Peiser | Hairstylist |
| Leslie Fuller | Makeup Artist |
| Veronique Lee | Assistant Production Coordinator |
| Amanda O'Reilly | Assistant Production Coordinator |
| Andy Gill | Stunt Coordinator |
| Pablo Helman | Second Unit Director |
| David Leitch | Second Unit Director |
| James Currier | Second Unit First Assistant Director |
| Noreen R. Cheleden | Second Assistant Director |
| Craig Pressgrove | First Assistant Camera |
| Kyle Knudson | First Assistant Camera |
| James A. Sylvia | Second Assistant Camera |
| Alex Worster | Second Assistant Camera |
| Alexander W. Lewis | Camera Loader |
| Ilya Akiyoshi | Digital Imaging Technician |
| Daniel McIntosh | Sound Mixer |
| Robert Mabin | Assistant Chief Lighting Technician |
| Gerard Lowry | Second Company Grip |
| Donald Glenn | Dolly Grip |
| Ian O'Neill | Dolly Grip |
| James Glenn | Grip |
| Veloz U.R. Gomez | Grip |
| Gary English | Hair Department Head |
| Rachel English | Makeup Artist |
| Jack Gill | Stunt Coordinator |
| Malu Miranda | Second Unit First Assistant Director |
| Fernando Zagallo | Production Manager |
| Fabricio Tadeu | Camera Operator |
| Sandro Galvão | Camera Operator |
| Eduardo Duque Pimenta | First Assistant Camera |
| Pedro Von Krüger | First Assistant Camera |
| Diogo Ribeiro | Second Assistant Camera |
| Nicolau Saldanha | Second Assistant Camera |
| Renato Mineirinho | First Company Grip |
| Edu Mourão | Second Company Grip |
| Gilberto Araujo | Second Company Grip |
| Alex Viana | Second Company Grip |
| Jazmin Castillo | Location Manager |
| Marcelo San Martin | Assistant Location Manager |
| Amanda Haddad | Production Coordinator |
| David B. Nowell | Aerial Director of Photography |
| Marissa Gomes | Visual Effects Producer |
| Shawn Kelly | Animation Supervisor |
| Julian Foddy | Visual Effects Supervisor |
| Dan Seddon | Visual Effects Supervisor |
| Nelson Sepulveda | Compositing Supervisor |
| Bryan Cantwell | CG Supervisor |
| Leandro Estebecorena | CG Supervisor |
| Danielle Legovich | Visual Effects Producer |
| Ben Lock | Visual Effects Producer |
| Thang Le | Visual Effects Art Director |
| Dan Wheaton | Visual Effects Art Director |
| Laurent Hugueniot | CG Supervisor |
| Anthony Zwartouw | CG Supervisor |
| Lorelei David | Visual Effects Editor |
| Sam Willing | Visual Effects Editor |
