 | Alexis Bledel als Ryden Malby |
 | Zach Gilford als Adam Davies |
 | Michael Keaton als Walter Malby |
 | Jane Lynch als Carmella Malby |
 | Bobby Coleman als Hunter Malby |
 | Carol Burnett als Grandma Maureen |
 | Rodrigo Santoro als David Santiago |
 | Catherine Reitman als Jessica Bard |
 | Mary Anne McGarry als Barbara Snaff |
 | J.K. Simmons als Roy Davies |
 | Robert Arce als Chancellor |
 | Jeanie Hackett als Woman at Graduation |
| Oscar Dillon als Security Guard |
 | Vanessa Branch als Receptionist |
 | Shirley Jordan als Interviewer |
 | Craig Robinson als Funeral Director |
 | Michael Grant Terry als College Grad |
 | Melissa Tang als College Friend #1 |
| Brandon Phillips als College Friend #2 |
 | Parisa Fitz-Henley als College Friend #3 |
 | Robert M. Koch als Gary the Buckle Man |
 | Fred Armisen als Guacanator Pitchman |
 | Don Stroud als Manager at the Mint |
 | Alexandra Holden als Cute Funky Girl |
 | Angel Oquendo als Police Officer |
 | Desean Terry als Young Cop |
 | Andy Daly als Lloyd Hastings |
 | Kirk Fox als Buckle-O-Bill |
 | Anna Khaja als Juanita |
| Gino Woulard als Box Car Racer #1 |
| Reid Harper als Box Car Racer #2 |
| Samantha Epstein als Box Car Racer #3 |
 | Patrick O'Connor als Landlord |
| Dempsey Pappion als Basketball Player |
 | Demetri Martin als TV Commercial Producer (uncredited) |
 | Basilina Butler als Graduation Parent (uncredited) |
| Jeremy Clark als Joe Schraeder (uncredited) |
 | Waymond Lee als Commencement Grad / Guest (uncredited) |
| Ray Reinebach als Violinist (uncredited) |
 | Lester G. Reynolds als Handcuffed Suspect (uncredited) |
 | Mahryah Shain als Magazine Editor (uncredited) |
| Matthew Thane als Fisherman (uncredited) |
| Vicky Jenson | Director |
| Kelly Fremon Craig | Writer |
| Michael Rizzo | Art Direction |
| Mark Hutman | Production Design |
| Alexandra Welker | Costume Design |
| Charles Minsky | Director of Photography |
| Joe Medjuck | Producer |
| Jeffrey Clifford | Producer |
| Steven R. McGlothen | Co-Producer |
| Hugh Conlon | Construction Coordinator |
| Ali Bell | Associate Producer |
| Ivan Reitman | Producer |
| Tom Pollock | Executive Producer |
| Joanna Colbert | Casting |
| Matthew Moriarty | Camera Operator |
| Colin Hudson | Camera Operator |
| Suzanne Tenner | Still Photographer |
| Paulina Kuszta | Visual Effects Coordinator |
| John E. Gray | Special Effects Coordinator |
| Rich Mento | Casting |
| Dana Congdon | Editor |
| Patrick Houlihan | Music Supervisor |
| Jason Rodriguez | Stunt Coordinator |
| Richard Reynolds | Set Designer |
| Thierry Labbe | Leadman |
| Bob Kensinger | Set Decoration |
| Steven R. McGlothen | Unit Production Manager |
| Schuyler Telleen | Art Department Coordinator |
| Tricia Ronten | Script Supervisor |
| Matthew Moriarty | Steadicam Operator |
| Deborah La Mia Denaver | Makeup Department Head |
| Jackie Bissley | Unit Publicist |
| Annette Dunford-Lewis | Costume Supervisor |
| John McAlary | Casting Associate |
| Roxane Griffin | Key Hair Stylist |
| Peter Tothpal | Hair Department Head |
| Trevor Metz | Sound Editor |
| Richard Dwan Jr. | Sound Editor |
| Jennifer L. Soulages | Costume Supervisor |
| Perry Robertson | Supervising Sound Effects Editor |
| Scott Sanders | Supervising Sound Editor |
| Aynee Osborn | Sound Editor |
| Fernand Bos | Music Editor |
| Chris Regan | Color Timer |
| Barry L. Caldwell | Script Supervisor |
| Bruce Szeles | Post Production Supervisor |
| Robert Ryan | Makeup Artist |
| Thomas Jones | Sound Editor |
| Wayne Middleton | Location Manager |
| Anthony J. Nahar | Second Assistant Director |
| Christophe Beck | Original Music Composer |
| Maryann Marchetti | Key Makeup Artist |
| Glenn Midcap | Transportation Coordinator |
| Jason Blumenfeld | First Assistant Director |
| Darryl Henley | Storyboard Artist |
| Jeffrey M. O'Brien | Property Master |
| Jon H. Epstein | Stunts |
| Troy Brown | Stunts |
| Tad Griffith | Stunts |
| Brian Brown | Stunts |
| Jayson Dumenigo | Stunts |
| Brian Duffy | Stunts |
| Mickey Cassidy | Stunts |
| Greg Fitzpatrick | Stunts |
| Clay Donahue Fontenot | Stunts |
| Samantha Epstein | Stunts |
| Reid Harper | Stunts |
| Bobby Porter | Stunts |
| Thomas Robinson Harper | Stunts |
| Tim Trella | Stunts |
| Keith Woulard | Stunts |
| Danny Wynands | Stunts |
| Susan Purkhiser | Stunts |
| Katina Waters | Stunts |
