 | Britt Robertson als Casey Newton |
 | George Clooney als Frank Walker |
 | Raffey Cassidy als Athena |
 | Hugh Laurie als David Nix |
 | Tim McGraw als Eddie Newton |
 | Chris Bauer als Frank's Dad |
 | Shiloh Nelson als Young Casey Newton |
 | Kathryn Hahn als Ursula |
 | Keegan-Michael Key als Hugo |
 | Thomas Robinson als Young Frank Walker |
 | Pierce Gagnon als Nate Newton |
 | Matthew MacCaull als Dave Clark |
 | Judy Greer als Jenny Newton |
 | Matthew Kevin Anderson als Bus Driver |
 | Michael Giacchino als Small World Operator |
 | D. Harlan Cutshall als Skyscraper Foreman |
 | Xantha Radley als History Teacher |
 | David Nykl als Science Teacher |
 | Paul McGillion als English Teacher |
 | Pearce Visser als Beefy Cop |
 | Garry Chalk als Jail Desk Jockey |
 | Dagan Nish als Jail Punk |
| Yusuf A. Ahmed als Jetpack Dexter |
 | Alex Barima als Jetpack Buddy |
 | Jedidiah Goodacre als Jetpack Buddy |
 | Kate Crutchlow als Monorail Mother |
 | Priya Rajaratnam als Young Astronaut |
 | Parm Soor als Astronaut's Father |
 | Leena Manro als Astronaut's Mother |
 | Rick Pearce als Pickup Driver |
 | Tom Butler als Police Captain |
 | Michael Rowe als Deputy |
 | Tim Perez als Deputy |
 | Patrick Sabongui als Eiffel Tower Guard #1 |
| Romuald Hivert als Eiffel Tower Guard #2 |
 | Mathieu Lardier als Pierre Clark |
 | Fraser Corbett als Jensen |
 | Darren Shahlavi als Tough Guard |
 | Aidan Gemme als Young British Recruiter |
| Takayuki Oki als Guitar Player |
 | Natasha Davidson als GM Plant Worker |
| Liliane Leilan Juma als Haitian Woman |
 | Paul Anthony als Thick Glasses (uncredited) |
| Kenia Arias als DQ Patron (uncredited) |
| Kimberly Arklie als Hero Bus Patron (uncredited) |
 | Nicholas Barrera als World's Fair Patron (uncredited) |
 | Barbara Keegan als World's Fair Patron (uncredited) |
 | Jason Bell als Dave Clark #7 (uncredited) |
| Wendy Bell als Guest (uncredited) |
| Aimee Bowen als Pedestrian (uncredited) |
| Chrystall Friedemann als World's Fair Lady (uncredited) |
 | PewDiePie als PewDiePie (uncredited) |
 | Darien Provost als Mikey (uncredited) |
 | Jackson Tessmer als 1964 World's Fair Boy (uncredited) |
 | Marcus Rosner als Handsome Harry (uncredited) |
| Julie Johnson als Harry's Girlfriend (uncredited) |
| Marshall Archibald als Justin (uncredited) |
 | Clint Carleton als Pierre Clark (uncredited) |
| Luis Castilleja als Gentleman - 1964 World Fair (uncredited) |
 | Ellen Marguerite Cullivan als Neighbor (uncredited) |
| Leslie Danielsen als DQ Patron (uncredited) |
 | Michael Ray Davis als Lonely Man (uncredited) |
| Peter Dwerryhouse als Nix Six (Scientist Financier) (uncredited) |
| Lindsey Elizabeth als Alice (uncredited) |
 | Amy Esterle als Greyhound Girl (uncredited) |
 | Monique Ganderton als Dave Clark #1 (uncredited) |
 | Glen Gordon als Donnie / Science Kid (uncredited) |
 | Kory Grim als Dave Clark Henchman (uncredited) |
 | Raiden Integra als Pedestrian (uncredited) |
| Anthony J. James als DQ Patron (uncredited) |
 | Tomas Johansson als 1964 World's Fair Patron (uncredited) |
| Kenneth Kantymir als Nix Six (uncredited) |
| Andrew Kerr als 1964 World's Fair Attendee (uncredited) |
| Joshua Lagos als Neighbor (uncredited) |
| Tommy Lentsch als Driver (uncredited) |
 | Laura MacKillop als Betsy (uncredited) |
 | Grae Marino als Motorist (uncredited) |
 | Catherine Michaud als Young Attendee (uncredited) |
 | Jaeda Lily Miller als Young Casey (uncredited) |
 | Lochlyn Munro als Uncle Anthony (uncredited) |
 | Aliyah O'Brien als Functionary (uncredited) |
 | Eddie Perez als Dick Clark #2 (uncredited) |
| Marc Primiani als World's Fair Patron (uncredited) |
| Kinley Rice als 1964 World Fair Girl (uncredited) |
| Kelly Riese als Woman in Car (uncredited) |
| Robin T. Rose als Game Warden (uncredited) |
 | Bruce Salomon als Max / Louis (uncredited) |
| Ranjit Samra als Pilot (uncredited) |
 | Manoj Sood als Economics Teacher (uncredited) |
| Damon Lindelof | Producer |
| Michael Giacchino | Original Music Composer |
| Brad Bird | Director |
| Damon Lindelof | Story |
| Brad Bird | Story |
| Damon Lindelof | Screenplay |
| Brad Bird | Screenplay |
| Yuhon Ng | Animation |
| Kyle Dunlevy | Animation |
| Mike Marcuzzi | Visual Effects |
| Jeff Jensen | Story |
| Martina Javorova | Art Direction |
| Dídac Bono | Art Direction |
| Jeremy Stanbridge | Art Direction |
| Lin MacDonald | Set Decoration |
| Jeffrey Kurland | Costume Design |
| Anne Carroll | Hairstylist |
| Alyssa Weisberg | Casting |
| Stephen Christensen | Art Direction |
| Walter Murch | Editor |
| Corinne Clark | Casting |
| April Webster | Casting |
| Luke Freeborn | Art Direction |
| Geoff Wallace | Art Direction |
| Jennifer Page | Casting |
| Scott Chambliss | Production Design |
| Monica Huppert | Makeup Department Head |
| Claudio Miranda | Director of Photography |
| Todd Cherniawsky | Art Direction |
| Craig Wood | Editor |
| Kelvin Humenny | Art Direction |
| Kimi Webber | Script Supervisor |
| Debbi Bossi | Associate Producer |
| Jeffrey Chernov | Producer |
| Brad Bird | Producer |
| Bernard Bellew | Executive Producer |
| BJ McDonnell | Steadicam Operator |
| Kimberly French | Still Photographer |
| Carie Wallis | Art Department Coordinator |
| Kristen Lindberg | Art Department Coordinator |
| Łukasz Bielan | Camera Operator |
| Sean M. Harding | Camera Operator |
| Alex Levy | Music Editor |
| Teresa Eckton | Foley |
| Jean-François Drigeard | Gaffer |
| Cheryl Nardi | Dialogue Editor |
| Anthony Almaraz | Set Costumer |
| David S. Warner | Gaffer |
| Dane Bjerno | Camera Technician |
| Deborah Rutherford | Makeup Artist |
| Juan Peralta | Sound Re-Recording Mixer |
| Gwendolyn Yates Whittle | Supervising Sound Editor |
| Lori Ellison | Set Costumer |
| Stephen S. Campanelli | Camera Operator |
| Peter Wilke | Steadicam Operator |
| Mariela Zapata | Set Costumer |
| Laurel Bergman | Assistant Art Director |
| David Tickell | Gaffer |
| Cristina Sopeña | Costume Supervisor |
| Jarrod Tiffin | Rigging Gaffer |
| Christine Youngstrom | Art Department Coordinator |
| Pamela Cameron | Set Costumer |
| Joey Campbell | Set Costumer |
| Zoe Jirik | Art Department Coordinator |
| Alyson Dee Moore | Foley |
| J.R. Grubbs | Sound Effects Editor |
| Bruce McCleery | Second Unit Cinematographer |
| David B. Nowell | Helicopter Camera |
| Natasha Gerasimova | Assistant Art Director |
| David Nakabayashi | Visual Effects Art Director |
| Hans Bjerno | Helicopter Camera |
| Margot Ready | Assistant Art Director |
| John Clothier | Steadicam Operator |
| Pascal Garneau | Foley |
| Gary Rydstrom | Sound Re-Recording Mixer |
| Silke Guglielmo | Set Costumer |
| Andrew Li | Assistant Art Director |
| Jeremy Bowker | Sound Effects Editor |
| Erik Messerschmidt | Gaffer |
| Richard Ramee | Rigging Gaffer |
| Sean Goojha | Assistant Art Director |
| Juanlo Prada Garrudo | Construction Coordinator |
| Tim Flattery | Conceptual Design |
| Joey Box | Stunt Coordinator |
| Charles Leitrants | Construction Coordinator |
| Robert Alonzo | Stunt Coordinator |
| Rick Climenhaga | Rigging Gaffer |
| Warren Brown | Music Editor |
| James Harris | Construction Coordinator |
| Kyrsten Mate | Sound Designer |
| Ramsey Avery | Supervising Art Director |
| Don MacAulay | Supervising Art Director |
| David Vyle Levy | Conceptual Design |
| Donald Dowd | Technical Advisor |
| Brad Kane | Visual Effects Coordinator |
| Ian Calip | Second Unit First Assistant Director |
| Gaelle Jego | Camera Trainee |
| Jeffrey Lynch | Second Unit Director |
| Doug Girling | Set Designer |
| Chris Castaldi | First Assistant Director |
| John Burke | Set Designer |
| Gil Forrester | Dolly Grip |
| Paula Antil | Third Assistant Director |
| Julio Fernández Santa | Key Grip |
| Brian Sepanzyk | Third Assistant Director |
| Slava Shmakin | Graphic Designer |
| Jairo Murray | Second Assistant Director |
| Tara Arnett | Graphic Designer |
| Kris Bergthorson | Set Designer |
| Nancy Anna Brown | Set Designer |
| Mira Caveno | Set Designer |
| Dianne Chadwick | Graphic Designer |
| Kim Olsen | Key Grip |
| Rhonda Taylor | Third Assistant Director |
| Tex Kadonaga | Set Designer |
| Daniel Perez Ferreira | Visual Effects Technical Director |
| Loren Robinson | VFX Artist |
| Monique Ganderton | Stunts |
| Janene Carleton | Stunts |
| Krista Bell | Stunt Double |
| Owen Walstrom | Stunts |
| John Walker | Executive Producer |
| Clint Carleton | Stunt Double |
| Jason Bell | Stunts |
