 | Lana Condor als Ruby Gillman (voice) |
 | Toni Collette als Agatha Gillman (voice) |
 | Annie Murphy als Chelsea Van Der Zee (voice) |
 | Sam Richardson als Uncle Brill (voice) |
 | Liza Koshy als Margo (voice) |
 | Will Forte als Gordon Lighthouse (voice) |
 | Colman Domingo als Arthur Gillman (voice) |
 | Jaboukie Young-White als Connor (voice) |
 | Blue Chapman als Sam Gillman (voice) |
 | Ramona Young als Bliss (voice) |
 | Eduardo Franco als Trevin (voice) |
 | Jane Fonda als Grandmamah (voice) |
 | Nicole Byer als Janice (voice) |
 | Echo Kellum als Doug (voice) |
 | Brianna Arsement als Home Buyer (voice) |
 | Juju Green als Gym Teacher / Coach (voice) |
 | Jordan Matter als School Principal (voice) |
 | Ricardo Hurtado als Student #1 / Student #10 (voice) |
 | Randy Thom als Confetti Cannon (voice) |
| Tiffany Wu als Student #7 (voice) |
| Merk Nguyen als Student #6 / Student #9 (voice) |
| Sydney Bell als Student #5 / Student #8 (voice) |
 | Atticus Shaindlin als Topher (voice) |
 | Lynnanne Zager als Phone Voice (voice) |
| Karen Foster als School Librarian (voice) |
 | Caleb Pierce als Student #3 (voice) |
| Qalil Ismail als Student #2 (voice) |
 | Suzanne Buirgy als Carol (voice) |
 | Emma Chamberlain als Reporter (voice) |
 | Preston Arsement als Tourist (voice) |
| Kirk DeMicco | Director |
| Faryn Pearl | Co-Director |
| Kelly Cooney Cilella | Producer |
| Stephanie Economou | Original Music Composer |
| Mike Mitchell | Executive Producer |
| Gary Rizzo | Sound Re-Recording Mixer |
| Leff Lefferts | Supervising Sound Editor |
| Rachel Zusser | Co-Producer |
| Randy Thom | Sound Designer |
| Craig Kellman | Character Designer |
| Joseph Izzo | Associate Producer |
| Brian C. Brown | Writer |
| Pam Brady | Writer |
| Elliott DiGuiseppi | Writer |
| Christi Soper Hilt | Casting |
| Maarten Lemmens | Animation |
| Pierre-Olivier Vincent | Production Design |
| Dave Walvoord | Visual Effects Supervisor |
| Carlos Fernandez Puertolas | Head of Animation |
| Jon Gutman | Director of Photography |
| Jon Gutman | Head of Layout |
| Jonathan Ciscon | Lighting Supervisor |
| Ariel Chisholm | Lighting Supervisor |
| C. Jin Im | Lighting Supervisor |
| John J. Lee | Lighting Supervisor |
| Michael Kevin Murphy | Supervising Technical Director |
| Glenn Harmon | Head of Story |
| Michelle Mendenhall | Editor |
| Kaki Bage | Production Manager |
| Tyler Shelton | Production Manager |
| Drew Adams | Animation Supervisor |
| Guillermo Careaga | Animation Supervisor |
| Michael Amos | Animation Supervisor |
| Anthony Hodgson | Animation Supervisor |
| Mark Roennigke | Animation Supervisor |
| Onur Yeldan | Animation Supervisor |
| Derek Cheung | Effects Supervisor |
| Mark Newport | Effects Supervisor |
| Alex Timchenko | Effects Supervisor |
| Jason Tenandar | Production Supervisor |
| Emily Cirillo | Production Supervisor |
| Juan Pablo Bugarin | Production Supervisor |
| Priyaa Kalkura | Production Supervisor |
| Rafe Parker Blood | Production Supervisor |
| Katie Felix | Production Supervisor |
| Rebecca M. Smith | Production Supervisor |
| Laura C. Denton | Production Supervisor |
| Jazmine Pulley | Production Supervisor |
| Brian Chumney | Supervising Sound Editor |
| Leff Lefferts | Sound Re-Recording Mixer |
| Nick Fletcher | Additional Editor |
| Mark Gillins | Associate Editor |
| C.K. Horness | Associate Editor |
| Corey Kraft | Associate Editor |
| Ted Fields | First Assistant Editor |
| Steffie Lucchesi | Assistant Editor |
| Nik Siefke | Assistant Editor |
| James Hereth | Assistant Editor |
| Timothy Lamb | Character Designer |
| David Perez | Character Designer |
| Taylor Krahenbuhl | Character Designer |
| Julien Le Roland | Character Designer |
| Guillermo Willie Real | Character Designer |
| Yvan Duque | Visual Development |
| Yuriko Oto | Visual Development |
| Alexandre Puvilland | Visual Development |
| Tom MacDougall | Visual Development |
| Ruben Perez | Visual Development |
| Paul Schoeni | Visual Development |
| Charles Ellison | Visual Development |
| Vahe Yefremian | Visual Development |
| Jesse Aclin | Character Designer |
| Lutgardo Fernández | Character Designer |
| Dom Murphy | Character Designer |
| Nico Marlet | Character Designer |
| Ronald A. Kurniawan | Visual Development |
| Sébastian Piquet | Visual Development |
| Tuan Vo | Visual Development |
| Steve Lewis | Visual Development |
| Rémi Salmon | Visual Development |
| Priscilla Wong | Visual Development |
| Stan Seo | Visual Development |
| Courtney Guess | Production Coordinator |
| Nora Jirau | Production Coordinator |
| Sarah Heinz | Production Coordinator |
| Ashley L. Martz | Production Coordinator |
| Robyne Powell | Lead Animator |
| Prashanth Cavale | Lead Animator |
| Tyler Phillips | Lead Animator |
| Shir Baron | Animation |
| Julien Bocabeille | Animation |
| Joseph Chong | Animation |
| Albert Rubio | Animation |
| David Couchariere | Animation |
| Ares Deveaux | Animation |
| Bill Diaz | Animation |
| Patrick Giusiano | Animation |
| Christopher Gonzalez | Animation |
| Thomas Grummt | Animation |
| Andrew Harkins | Animation |
| Martin P. Hopkins | Animation |
| John Hill | Animation |
| Jorge García | Animation |
| David Guo | Animation |
| Robert Christian Huth | Animation |
| Aly Killian | Animation |
| Kyle Kim | Animation |
| Brendan Kirschbaum | Animation |
| Marek Kochout | Animation |
| Lindsey Butterworth Langston | Animation |
| Philippe Le Brun | Animation |
| David Lisbe | Animation |
| Alvaro Michelena | Animation |
| Garrett O'Neal | Animation |
| Ryan Page | Animation |
| Yung Pham | Animation |
| Nicolas Prothais | Animation |
| William Salazar | Animation |
| JP Sans | Animation |
| Ivan Oviedo | Animation |
| Steve Vanseth | Animation |
| Dan Wagner | Animation |
| Greg Whittaker | Animation |
| John Wong | Animation |
| Steven Hornby | Animation |
| Brian Menz | Animation |
| Jeff Williams | Animation |
| Nedy Acet | Animation |
| Patrick Danaher | Animation |
| John Han | Assistant Editor |
| David C. Hughes | Sound Effects Editor |
| Shaun Farley | Sound Effects Editor |
| Anthony De Francesco | Dialogue Editor |
| Greg J. Peterson | First Assistant Sound Editor |
| Jana Vance | Foley Artist |
| Ronni Brown | Foley Artist |
| Chris Manning | Foley Editor |
| Rick Hromadka | Sound Designer |
| Sheri Ozeki | Music Editor |
| Stephanie Economou | Conductor |
| Jennifer Dirkes | Orchestrator |
| Hal Rosenfeld | Orchestrator |
| Tom McGrath | Thanks |
| Joel Crawford | Thanks |
| Colin Jack | Thanks |
| James Ryan | Thanks |
| Mark Edwards | Thanks |
| Januel Mercado | Thanks |
| Jerry Schmitz | Thanks |
| Nicole Holofcener | Thanks |
| Paul Tibbitt | Thanks |
| Nick Levenduski | In Memory Of |
| Tony Villaflor | Sound Re-Recording Mixer |
| Randy Thom | Sound Re-Recording Mixer |
