 | Tobin Bell als John Kramer / Jigsaw |
 | Donnie Wahlberg als Eric Matthews |
 | Shawnee Smith als Amanda Young |
 | Erik Knudsen als Daniel Matthews |
 | Franky G als Xavier Chavez |
 | Glenn Plummer als Jonas Singer |
 | Emmanuelle Vaugier als Addison Corday |
 | Beverley Mitchell als Laura Hunter |
 | Noam Jenkins als Michael Marks |
 | Timothy Burd als Obi Tate |
 | Dina Meyer als Allison Kerry |
 | Lyriq Bent als Daniel Rigg |
 | Tony Nappo als Gus Colyard |
 | Kelly Jones als SWAT Member Pete |
 | Vincent Rother als SWAT Member Joe |
 | Linette Doherty als Mother in Cancer Ward |
 | Kofi Payton als Boy in Cancer Ward |
| Gretchen Helbig als Nurse in Cancer Ward |
 | Leigh Whannell als Adam Stanheight (voice) (uncredited) |
 | Cary Elwes als Dr. Lawrence Gordon (archive sound) (uncredited) |
 | Ho Chow als Security Officer |
| Darren Lynn Bousman | Director |
| Leigh Whannell | Screenplay |
| Darren Lynn Bousman | Screenplay |
| Mark Burg | Producer |
| Gregg Hoffman | Producer |
| Oren Koules | Producer |
| Charlie Clouser | Original Music Composer |
| David A. Armstrong | Director of Photography |
| Kevin Greutert | Editor |
| Stephanie Gorin | Casting |
| Amy Lippens | Casting |
| David Hackl | Production Design |
| Mark Gingras | Supervising Sound Editor |
| Alex Kavanagh | Costume Design |
| Michele Brady | Art Direction |
| Liesl Deslauriers | Set Decoration |
| Peter Block | Executive Producer |
| Jason Constantine | Executive Producer |
| Daniel J. Heffner | Co-Producer |
| Stacey Testro | Executive Producer |
| James Wan | Executive Producer |
| Leigh Whannell | Executive Producer |
| Dwight Hendrickson | Assistant Art Director |
| Jamie Burke | Construction Coordinator |
| Carlo Cesta | Painter |
| Anthony Pearce | Conceptual Illustrator |
| Brent McGillivray | Set Designer |
| Kevin LeBlanc | First Assistant Camera |
| Chris Faulkner | Key Grip |
| Tyler Faulkner | Grip |
| Steve Wilkie | Still Photographer |
| Stephanie Lees | Assistant Costume Designer |
| Stephanie Ingram | Key Hair Stylist |
| Sarah Fairbairn | Key Makeup Artist |
| Steven Ciancamerla | Set Dressing Artist |
| Al Vrkljan | Armorer |
| Rupert Blab | Carpenter |
| David Kinnersly | Craft Service |
| Dave Murray | Driver |
| Jan Brunton | Camera Loader |
| Neil Morrill | Makeup Effects |
| W. Michael Beard | Post Production Supervisor |
| James R. Murray | Property Master |
| Angelo Barillaro | Security |
| Lauren Hassard | Set Medic |
| Armen Kazazian | Set Production Assistant |
| Bill Bibert | Stand In |
| Alison Reid | Stunt Coordinator |
| Eddie Bowman | Transportation Coordinator |
| Elizabeth Scherberger | First Assistant Director |
| Lisa Burling | Script Supervisor |
| Ryan Ruskay | Color Timer |
| Allan Fung | Dialogue Editor |
| Ron Wisman Jr. | First Assistant Editor |
| Craig Black | Electrician |
| Harold D. Stroud | Gaffer |
| Stephanie Laffin | Casting Associate |
| Thomas Vencelides | Location Manager |
| Kym Crepin | Production Accountant |
| Cristin L. Cornett | Production Coordinator |
| Jason Hopfner | Boom Operator |
| Robin Crumley | Assistant Sound Editor |
| Rob Bertola | Music Editor |
| Jonathan McHugh | Music Supervisor |
| Tom Bjelic | Sound Effects Editor |
| Rick Penn | Sound Mixer |
| Tim Good | Special Effects Supervisor |
| Natasha North | Visual Effects Coordinator |
| Chad Malbon | Visual Effects Producer |
| Bret Culp | Visual Effects Supervisor |
| Heather Dawn | Creative Consultant |
| Chris Watson | Best Boy Electrician |
| Mike Curtis | Electrician |
| Cinar Eryasar | Electrician |
| Kevin McKague | Electrician |
| Dave Sansford | Electrician |
| Scott Tremblay | Electrician |
| Brian Gedge | Camera Operator |
| Kit Whitmore | Camera Operator |
| Brian Gedge | Second Unit Director of Photography |
| Stewart Grayburn | Dolly Grip |
| Rahul Parekh | Dolly Grip |
| John Stubbings | Techno Crane Operator |
| Les Handrahan | Costume Coordinator |
| Candice Ornstein | Assistant Makeup Artist |
| Deirdre Dodds | On Set Dresser |
| Darrin Brown | Second Assistant Director |
| Brian Backman | Third Assistant Director |
| Tereza Radman | Art Department Trainee |
| Rae Crombie | Assistant Property Master |
| Rick Fernandez | Head Carpenter |
| Suzanne Hoffman | Lead Set Dresser |
| Hamish Buchanan | Second Assistant Art Director |
| Matthew Howlett | Set Buyer |
| Ron Hobbs | Storyboard Artist |
| Matthew McKenzie | ADR Recordist |
| Steve Baine | Foley Artist |
| Peter Persaud | Foley Recordist |
| John Douglas Smith | Supervising Dialogue Editor |
| Carrie Richardson | Visual Effects Production Manager |
| Wade Eastwood | Stunt Double |
| Geoff Pope | Best Boy Grip |
| Alex Lisman | Camera Trainee |
| Eric Beaulieu | Second Assistant Camera |
| Janelle Scuderi | Casting Assistant |
| Tom Mayclim | Negative Cutter |
| Roberta Bratti | Project Manager |
| Roger Lumyoung | Assistant Location Manager |
| Thomas D. Mahoney | Music Coordinator |
| Lisa Gyorfi | Assistant Production Coordinator |
| Kris Brockman | Digital Compositor |
| Jane Rogers | Extras Casting |
| Carla Spizziri | First Assistant Accountant |
| Sean Armstrong | Key Special Effects |
| Pauline K. Quong | Payroll Accountant |
| Kris Wood | Playback Coordinator |
| Ryan Eldridge | Production Assistant |
| Charles Taylor | Weapons Wrangler |
| Andrew Tay | Sound Re-Recording Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Brian Jagersky | Stunts |
| Darren McGuire | Stunts |
| John Stoneham Jr. | Stunts |
| Greg Copeland | Co-Producer |
| Greg Copeland | Production Manager |
| Greg Copeland | Second Unit Director |
| Leigh Whannell | Original Film Writer |
| James Wan | Original Film Writer |
| Alison Reid | Stunt Double |
| Dave Van Zeyl | Stunt Double |
