 | Anna Faris als Cindy Campbell |
 | Simon Rex als George |
 | Anthony Anderson als Mahalik |
 | Charlie Sheen als Tom |
 | Regina Hall als Brenda Meeks |
 | Leslie Nielsen als President Baxter Harris |
 | Kevin Hart als CJ |
 | Jeremy Piven als Ross Giggins |
 | Pamela Anderson als Becca |
 | Jenny McCarthy-Wahlberg als Kate |
 | Denise Richards als Annie |
 | Elaine Klimaszewski als Elaine |
 | Diane Klimaszewski als Diane |
 | Drew Mikuska als Cody |
 | Jianna Ballard als Sue |
 | George Carlin als Architect |
 | Queen Latifah als Aunt Shaneequa / The Oracle |
 | Eddie Griffin als Orpheus |
 | Camryn Manheim als Trooper Champlin |
 | Marny Eng als Tabitha |
 | Timothy Stack als Carson Ward |
 | Darrell Hammond als Father Muldoon |
 | Dexter Bell als Toilet Guy |
 | Dame Lee als Rapper #1 |
 | Doron Bell als Rapper #2 |
 | Simon Cowell als Simon Cowell |
 | Fat Joe als Fat Joe |
 | Ajay Naidu als Sayaman |
 | William S. Taylor als Mr. Meeks |
| Patricia Idlette als Mrs. Meeks |
| David Edwards als Ralph |
 | Frank C. Turner als Mr. Meek's Brother |
| Monica Dillon als Brenda's Grandmother |
| Lori Stewart als Tabitha's Mother |
| Jim Bremner als Guy in Chair |
| Phil Dornfeld als Tabitha's Voice (voice) |
 | Edward Moss als MJ |
 | Dee Jay Jackson als Zubie |
 | D.L. Hughley als John Wilson |
 | Ja Rule als Agent Thompson |
 | Macy Gray als Macy Gray |
 | Redman als Redman |
 | Method Man als Method Man |
 | Raekwon als Raekwon |
 | RZA als RZA |
 | U-God als U-God |
 | Troy Yorke als Alien #1 |
 | Marco Soriano als Alien #2 |
| Cliff Solomon als Native American #1 |
 | Byron Chief-Moon als Native American #2 |
| Dolly Madsen als Native American #3 |
 | John Hainsworth als Tracheotomy Man |
 | Beverley Breuer als Tracheotomy Wife |
| Jessie Young als Girl Scout |
| Deanne Henry als Tammy Fae Baker |
 | Eric Breker als Secret Serviceman Jones |
| Naomi Lawson-Baird als Sweet Tabitha |
| Abigail Adams als Wedding Guest |
 | Master P als P Masters |
 | Debbie Lee Carrington als Mini Tabitha (uncredited) |
| Buddy Johnson | Characters |
| Mark Irwin | Director of Photography |
| William Heslup | Art Direction |
| John Papsidera | Casting |
| Shawn Wayans | Characters |
| Robert K. Weiss | Producer |
| Carol Ramsey | Costume Design |
| Phil Beauman | Characters |
| Craig Mazin | Screenplay |
| Pat Proft | Screenplay |
| Marlon Wayans | Characters |
| Jason Friedberg | Characters |
| David Zucker | Director |
| Aaron Seltzer | Characters |
| Malcolm Campbell | Editor |
| Jon Poll | Editor |
| William A. Elliott | Production Design |
| Mike McLeod | Construction Foreman |
| Rose Marie McSherry | Set Decoration |
| Kumvana Gomani | Art Department Assistant |
| Bob Weinstein | Executive Producer |
| Grace Gilroy | Co-Producer |
| Brad Weston | Executive Producer |
| Harvey Weinstein | Executive Producer |
| Kevin Marcy | Associate Producer |
| James L. Venable | Original Music Composer |
| Andrew Rona | Executive Producer |
| Phil Dornfeld | Associate Producer |
| James Bamford | Stunts |
| J.J. Makaro | Stunt Coordinator |
| Robert MacLean | Picture Car Coordinator |
| Grace Gilroy | Unit Production Manager |
| Tim Clawson | Executive In Charge Of Production |
| Tony Giacinti | Boom Operator |
| Larry Sutton | Production Sound Mixer |
| Joe Henke | Animation Supervisor |
| Tamara Watts Kent | Visual Effects Producer |
| Marni Grossman | Still Photographer |
| Barbara Chomos | Unit Publicist |
| Colin Maier | Video Assist Operator |
| Maryjane Layani | Production Accountant |
| Andrei Andrianko | Set Designer |
| Lee Novak | Key Hair Stylist |
| Fitch Cady | Unit Manager |
| Kimberley Buchanan | Stand In |
| Yves Bernadet | Gaffer |
| Frank Fitzpatrick | Music Supervisor |
| Patrick Hunt | Lead Painter |
| Fred Lawrence | Painter |
| Grant Janssen | Systems Administrators & Support |
| Dell Hake | Orchestrator |
| Davis Fandino | Sculptor |
| Chris Hayward | Standby Painter |
| Max Chickite | Carpenter |
| Bill Coffin | Digital Effects Supervisor |
| Craig Alpert | First Assistant Editor |
| John C. Carlucci | Special Effects Supervisor |
| Alex Kameniczky | Assistant Art Director |
| Brian Patterson | Projection |
| Rob Cantin | Lighting Technician |
| Pat Weber | Score Engineer |
| Anand Kanna | Location Scout |
| Kevin Garcia | First Assistant Camera |
| Céline Godeau | Makeup Effects |
| Wendy Lewis | Production Coordinator |
| Kirsten Franson | Production Illustrator |
| Larry Baldwin | Driver |
| Sue Swift | Scenic Artist |
| Lee Scott | Music Editor |
| Michelle Butler | Digital Compositors |
| Stuart Robertson | Visual Effects Supervisor |
| Dan Rizzuto | Utility Stunts |
| Gaetan Jalbert | Rigging Gaffer |
| Jason W. Jennings | Sound Effects Editor |
| Ninon Tantet | Post Production Supervisor |
| Dean Rama | Transportation Captain |
| George H. Anderson | Sound Designer |
| Ulrika Akander | Sound Editor |
| Shawn Timoteo | Chef |
| Tony Lazarowich | Special Effects Coordinator |
| Chris Regan | Color Timer |
| Wendy O'Brien | Casting Associate |
| Chris B. Schnitzer | Visual Effects Coordinator |
| Michelle Gasque | Art Department Coordinator |
| Kelli Bell | Post Production Assistant |
| Martin Allan Kloner | Visual Effects Editor |
| Saubrie Mohamed | Best Boy Electric |
| Geoff Teoli | Location Manager |
| Michael J. Benavente | Supervising Sound Editor |
| Siegfried Stock | Machinist |
| Doug Hardwick | Construction Coordinator |
| Tim Moynihan | Steadicam Operator |
| Aieisha Li | Set Costumer |
| Lisa Chalmers | Craft Service |
| Michael Bolan | Helicopter Camera |
| Gail Barrett | Costume Supervisor |
| Lisa Ashley | Hairstylist |
| Stacey Butterworth | Wigmaker |
| Jon Paris | Additional Music |
| Robert Milicevic | Security |
| Jorge Corante | Songs |
| Paula Bradley | Assistant Costume Designer |
| Dan Johnson | Transportation Co-Captain |
| Jake Callihoo | Transportation Coordinator |
| Richard Beech | Set Dresser |
| Kate Vanderbyl | Second Assistant Director |
| Timothy Huizing | Prosthetic Makeup Artist |
| Michael Dressel | Foley Editor |
| Dan Bennett | Key Grip |
| Sarah Bourgeois | Assistant Sound Editor |
| Tristan Oliver | Assistant Set Dresser |
| Gillian Goodman | Assistant Property Master |
| Hugo Weng | ADR Editor |
| Tom Boyd | Musician |
| Wendy L. Adjoury | Third Assistant Director |
| Mike Dodd | Grip |
| Lisa Taylor Roberts | Key Makeup Artist |
| Gary Burritt | Negative Cutter |
| Doug Metzger | First Assistant Director |
| Bruce Babcock | Conductor |
| Joel Echallier | Animatronics Supervisor |
| Kim Boyle | Digital Effects Producer |
| Josephine Ochej | Casting Assistant |
| James A. Brewer | Associate Editor |
| Alex Gibson | Supervising Music Editor |
| Jason Crosby | Marine Coordinator |
| Jack Cruikshank | Dolly Grip |
| Edward Moss | Fight Choreographer |
| Jay W. Yowler | Chief Lighting Technician |
| J. B. Bivens | Rigging Grip |
| Jeena M. Phelps | Dialogue Editor |
| James Matheny | Dialogue Editor |
| Pamela Kahn | Foley Artist |
| Graham Coutts | Property Master |
| Vincent Guisetti | Foley Artist |
| Kyle Rochlin | Foley Mixer |
| Dennis Johnson | Sound Recordist |
| Anne-Marie Leidl | Graphic Designer |
| Daniel Birczynski | Assistant Sound Engineer |
| Patrick Kavanaugh | Compositing Supervisor |
| Wendy L. Adjoury | Production Assistant |
| Narges Takesh | Story Editor |
| Bill Kent | Additional Visual Effects |
| Elaine K. Thompson | Post Production Coordinator |
| Breanne Larrett | Second Assistant Production Coordinator |
| Rob Miller | Contact Lens Technician |
| Tricia Linklater | First Assistant Sound Editor |
| Tom Evans | Best Boy Grip |
| Jeff Etcher | Assistant Editor |
| Tim Boddington | Assistant Chef |
| Carol Urquhart | First Assistant Accountant |
| Rebeccah Delchambre | First Assistant Makeup Artist |
| Adam Sharpe | ADR Mixer |
| Kyle T. Moore | Special Effects Technician |
| Sherry Boyd | Stunt Double |
| Ishi Dinim | Camera Trainee |
| Renee Bella | Assistant Location Manager |
| Donald Fly | General Manager |
| Jack Firman | Special Effects Assistant |
| Viktoria Langton | Choreographer |
| Vincent Dela Luna | Key Production Assistant |
| John Le Roy | Key Rigging Grip |
| Vanessa Cheung | Matte Painter |
| Tamar Ouziel | Assistant Makeup Artist |
| Brenda Knight | Costumer |
| Michele Lyle | Costume Set Supervisor |
| Sonia Gilmore | Extras Casting Coordinator |
| Nelson Dewey | Storyboard Artist |
| Terron Pratt | Visual Effects Production Assistant |
| Anna Lary | Generator Operator |
| Ron Andrews | Paint Coordinator |
| Errin Lally | Casting Coordinator |
| Annette McCaffrey | Extras Casting |
| Summer Dietz | Truck Costumer |
| Robert M. Stevens | Second Unit Director |
| David Smithson | Data Wrangler |
| Anna Bosa | Second Assistant Camera |
| Loren Bagelman | Location Production Assistant |
| Colin Gillis | Production Runner |
| Amy Garback | CG Artist |
| Jill Krop | Technical Advisor |
| Jan Holmsten | Construction Buyer |
| Glenn Foerster | Head Greensman |
| Carmen Lavender | Sound Assistant |
| Fred Stephens | Cast Driver |
| Rashid Ahmed | Payroll Accountant |
| Scott R. Treliving | Special Effects Best Boy |
| Alejandro Valdés-Rochin | Visual Effects Assistant Editor |
| Kamala Fritzler | Casting Assistant |
| Diana Tauder | Additional Post-Production Supervisor |
| Abigail Tucker | First Assistant Production Coordinator |
| Doug Chapman | Stunts |
| Sophia M. Crawford | Stunt Double |
| Marny Eng | Stunts |
| Crystal Dalman | Stunts |
| Dalias Blake | Stunts |
| Dexter Bell | Stunts |
| Lloyd Adams | Stunts |
| Mark Aisbett | Stunts |
| Joe Doserro | Stunts |
| Jwaundace Candece | Stunts |
| Dario Delacio | Stunts |
| Duane Dickinson | Stunts |
| Raymond Chan | Stunts |
| Jim Dunn | Stunts |
| Caroline Field | Stunts |
| Alana Husband | Stunts |
| Kathy Hubble | Stunts |
| Tom Glass | Stunts |
| Don Lew | Stunts |
| Andrea Kinsky | Stunts |
| J.J. Makaro | Stunts |
| Deb Macatumpag | Stunts |
| Jacob Rupp | Stunt Coordinator |
| Lori Stewart | Stunts |
| Efosa Otuomagie | Stunts |
| Heather Feeney | Stunts |
| Kimani Ray Smith | Stunts |
| Nicole Lissner | Stunts |
| Sharon Simms | Stunts |
| David Mylrea | Stunts |
| Laura Lee Connery | Stunt Double |
| Raymond Sammel | Stunts |
| Daniel B. Melles | Stunts |
| Gaston Morrison | Stunts |
| Braden Haggerty | Stunts |
| Mark Holden | Stunts |
| Connor Dunn | Stunts |
| Bill Edwards | Stunts |
| Lani Gelera | Stunts |
| Reg Glass | Stunts |
| Monica Dillon | Stunts |
| Simon Burnett | Stunts |
| Dustin Brooks | Stunts |
| Lou Bollo | Stunts |
| Barb Bartos | Stunts |
| Charles Andre | Stunts |
| Dave Alexander | Stunts |
| Ashlea Earl | Stunts |
| Rikki Gagne | Stunt Double |
| Guyle Fraizer | Stunts |
