 | Billy Bob Thornton als Dr. P |
 | Jon Heder als Roger |
 | Jacinda Barrett als Amanda |
 | Sarah Silverman als Becky |
 | Michael Clarke Duncan als Lesher |
 | David Cross als Ian |
 | Horatio Sanz als Diego |
 | Matt Walsh als Walsh |
 | Todd Louiso als Eli |
 | Ben Stiller als Lonnie |
 | Luis Guzmán als Sergeant Moorehead |
 | Dan Fogler als Zack |
 | DeRay Davis als Bee Bee |
 | Jon Glaser als Ernie |
 | Paul Scheer als Little Pete |
 | Joanne Baron als Lois |
 | Omar J. Dorsey als Lawrence |
 | Marcella Lowery als Mrs. Washington |
 | Leonard Earl Howze als Classmate |
 | Jim Parsons als Classmate |
 | Aziz Ansari als Classmate |
 | Remy K. Selma als Classmate |
 | Andy Daly als Classmate |
 | Bob Stephenson als Classmate |
 | Jack Kehler als Classmate |
 | Noel Gugliemi als Subway Guy |
 | Daniel Venegas als Subway Guy |
 | Jessica Stroup als Eli's Wife |
 | Lizz Carter als Flight Attendant |
 | Steve Monroe als Flight Attendant |
 | Malika als Margaret (uncredited) |
 | Khadijah Haqq McCray als Mindy (uncredited) |
 | Nicole Randall Johnson als Shanice (uncredited) |
 | Che Landon als Waitress (uncredited) |
| Chris Rubio als Airplane Passenger (uncredited) |
 | Bernadette Birkett als Woman (uncredited) |
| Todd Phillips | Director |
| Dan Schalk | Editor |
| Craig Mazin | Executive Producer |
| Todd Phillips | Producer |
| Geyer Kosinski | Producer |
| Christophe Beck | Original Music Composer |
| Jonathan Brown | Director of Photography |
| Leslie Jones | Editor |
| Hal E. Chester | Executive Producer |
| Annette Savitch | Producer |
| Nelson Coates | Production Design |
| Louise Mingenbach | Costume Design |
| Harvey Weinstein | Executive Producer |
| Daniel Goldberg | Producer |
| Jeanne McCarthy | Casting |
| Bob Weinstein | Executive Producer |
| Scot Armstrong | Screenplay |
| Scott Meehan | Art Direction |
| Denise Pizzini | Set Decoration |
| Stephen Potter | Novel |
| Randall Poster | Music Supervisor |
| George Drakoulias | Music Supervisor |
| JoAnn Perritano | Co-Producer |
| Scott Budnick | Co-Producer |
| Jennifer Conroy | Production Supervisor |
| Kirk R. Gardner | "A" Camera Operator |
| Erik L. Brown | First Assistant "A" Camera |
| Anthony Hardwick | "B" Camera Operator |
| John Waldo | First Assistant "B" Camera |
| Tricia Ronten | Script Supervisor |
| Patrick Esposito | Post Production Supervisor |
| Michael Babcock | Supervising Sound Editor |
| Michael Babcock | Sound Re-Recording Mixer |
| Michael Minkler | Sound Re-Recording Mixer |
| Kim H. Ornitz | Sound Mixer |
| Mychal D. Smith | Boom Operator |
| Michael J. Hogan | Video Assist Operator |
| Brad Einhorn | Property Master |
| Tracy Bennett | Still Photographer |
| Will Casey | Unit Publicist |
| Lee Wimer | Color Timer |
| Gary Burritt | Negative Cutter |
| Jill Brown | Stunts |
| Hal E. Chester | Original Film Writer |
| Todd Phillips | Screenplay |
| Patricia Moyes | Original Film Writer |
| G. A. Aguilar | Second Unit Director |
| Steve Kelso | Stunt Double |
