 | Frank Welker als Scooby-Doo / Fred Jones (voice) |
 | Mindy Cohn als Velma Dinkley (voice) |
 | Grey DeLisle als Daphne Blake (voice) |
 | Matthew Lillard als Shaggy Rogers (voice) |
 | Isabella Acres als Emma Gale (voice) |
 | Troy Baker als The Phantom / Lance Damon (voice) |
 | Eric Bauza als K.J. (voice) |
 | Jeff Bennett als Mike Gale/ Mel Richmond (voice) |
 | Wayne Brady als Brick Pimiento (voice) |
 | Vivica A. Fox als Lotte Lavoie (voice) |
 | Kate Higgins als Meg Gale / Cathy (voice) |
 | Peter MacNicol als Dewey Ottman (voices) |
 | Candi Milo als Barb Damon (voice) |
 | John O'Hurley als The Great Pauldini (voice) |
 | Cristina Pucelli als Colette (voice) |
 | Kevin Michael Richardson als Security Guard #1 / Hotel Clerk (voice) |
 | Paul Rugg als Steve Trilby (voice) |
 | Tara Sands als Nancy (voice) |
 | Tara Strong als News Anchor / Donna (voice) |
 | Travis Willingham als Waldo (voice) |
 | Ariel Winter als Chrissy Damon (voice) |
| Victor Cook | Director |
| Kaukab Basheer | Art Department Manager |
| Doug Langdale | Writer |
| William Hanna | Characters |
| Joseph Barbera | Characters |
| Victor Cook | Producer |
| Robert J. Kral | Original Music Composer |
| Collette Sunderman | Casting |
| Bruce King | Editor |
| Ted Blackman | Art Direction |
| Eric Semones | Art Direction |
| Doug Langdale | Story |
| Candie Langdale | Story |
| Doug Langdale | Teleplay |
| Alan Burnett | Co-Producer |
| Jason Wyatt | Line Producer |
| Sam Register | Executive Producer |
| Scott Shinick | Post-Production Manager |
| Mark A. Keatts | Supervising Dialogue Editor |
| Mark A. Keatts | ADR Editor |
| Kelly Ann Foley | Dialogue Editor |
| Kelly Ann Foley | ADR Editor |
| Patrick J. Foley | Dialogue Editor |
| Patrick J. Foley | ADR Editor |
| Michael Garcia | Dialogue Editor |
| Michael Garcia | ADR Editor |
| Steven White | Online Editor |
| Christine H. Luethje | Music Editor |
| Niki Sherrod | Other |
| Liz Carroll | Administration |
| Bobbie Page | Production Supervisor |
| Ed Adams | Production Manager |
| Jay Bastian | Executive In Charge Of Production |
