 | David Arquette als Dewey Riley |
 | Neve Campbell als Sidney Prescott |
 | Courteney Cox als Gale Weathers |
 | Emma Roberts als Jill Roberts |
 | Hayden Panettiere als Kirby Reed |
 | Anthony Anderson als Deputy Perkins |
 | Adam Brody als Deputy Hoss |
 | Rory Culkin als Charlie Walker |
 | Mary McDonnell als Kate Roberts |
 | Marley Shelton als Deputy Judy Hicks |
 | Alison Brie als Rebecca Walters |
 | Marielle Jaffe als Olivia Morris |
 | Nico Tortorella als Trevor Sheldon |
 | Erik Knudsen als Robbie Mercer |
 | Anna Paquin als Rachel |
 | Kristen Bell als Chloe |
 | Lucy Hale als Sherrie |
 | Shenae Grimes-Beech als Trudie |
 | Britt Robertson als Marnie Cooper |
 | Aimee Teegarden als Jenny Randall |
 | Roger L. Jackson als Ghostface (voice) |
 | Nancy O'Dell als TV Host |
 | Justin Michael Brandt als Film Geek |
 | Dane Farwell als Ghostface |
 | Gordon Michaels als Deputy Jenkins |
 | John Lepard als Mr. Baker |
| Kim Adams als Reporter #2 |
 | Devin Scillian als Reporter #3 |
| Mark Aaron Buerkle als Dr. Orth |
| Julia Ho als Amy the Reporter |
| Alexander Punch als Cocky Student |
| Glenda Lewis als Reporter #4 |
| William Spencer als Reporter #5 |
| Tim Doty als Reporter #6 |
 | Peter Carey als Reporter #7 |
 | Wes Craven als Coroner (uncredited) |
| Wes Craven | Director |
| Kevin Williamson | Characters |
| Peter Deming | Director of Photography |
| Kevin Williamson | Producer |
| Wes Craven | Producer |
| Marianne Maddalena | Executive Producer |
| Ron Schmidt | Executive Producer |
| Kevin Williamson | Screenplay |
| Brian Avery | Stunts |
| Karin Silvestri | Stunts |
| Adam Stockhausen | Production Design |
| Bob Weinstein | Executive Producer |
| Harvey Weinstein | Executive Producer |
| Ehren Kruger | Executive Producer |
| Marco Beltrami | Music |
| Peter McNulty | Editor |
| Avy Kaufman | Casting |
| Nancy Nayor | Casting |
| Gerald Sullivan | Art Direction |
| Helen Britten | Set Decoration |
| Debra McGuire | Costume Design |
| William Bernardin | In Memory Of |
| Renae Moneymaker | Stunts |
| Karin Silvestri | Stunt Double |
| Ann Scott | Stunt Double |
| Dana Reed | Stunt Double |
| Dailyn Matthews | Stunts |
| Cassidy Vick Hice | Stunt Double |
| Stacey Carino | Stunt Double |
| Allison Caetano | Stunt Double |
| Iya Labunka | Producer |
| Matthew Stein | Executive Producer |
| Cathy Konrad | Executive Producer |
| Carly Feingold | Co-Producer |
| Liza Richardson | Music Supervisor |
| Ron Schmidt | Unit Production Manager |
| Nicholas Mastandrea | First Assistant Director |
| Maria Mantia | Second Assistant Director |
| Troy Brown | Stunt Coordinator |
| Riley Harper | Stunt Double |
| Banzai Vitale | Stunt Driver |
| Richard E. Chapla Jr. | Production Supervisor |
| Eric Bergman | Post Production Supervisor |
| Patrick Esposito | Post Production Supervisor |
| Brendan Walsh | Additional Editor |
| David Eubank | First Assistant "A" Camera |
| Claire Farrand-Stone | Second Assistant "A" Camera |
| George Billinger III | "B" Camera Operator |
| Jeffree Bloomer | Production Sound Mixer |
| Anastacia C. Nemec | Second Second Assistant Director |
| Lori Grabowski | Script Supervisor |
| Jay Fortune | Gaffer |
| Philip Sloan | Key Grip |
| J.P. Jones | Property Master |
| Diane Crooke | Costume Supervisor |
| Joy Zapata | Hair Department Head |
| Peter Robb-King | Makeup Department Head |
| M.K. Gleason | Production Accountant |
| Georgina Marquis | Production Coordinator |
| Logan Cooper | Location Manager |
| Ron Bolanowski | Special Effects Supervisor |
| Jody Gaber | Art Department Coordinator |
| Emma Stensaas | Art Department Assistant |
| Thomas Traugott | Leadman |
| Gemma La Mana | Still Photographer |
| Phil Bray | Still Photographer |
| Anthony Cargioli | Boom Operator |
| Catherine Hahn | Key Costumer |
| Jennifer Kamrath | Key Costumer |
| Kristi Hoffman | Set Costumer |
| Megan Wiser | Costumer |
| Maggie Fung | Key Makeup Artist |
| Norma Lee | Key Hair Stylist |
| Dawn Mattocks | Hairstylist |
| Gary J. Tunnicliffe | Prosthetic Designer |
| Skip Crank | Assistant Property Master |
| Brian McClean | Best Boy Electric |
| Brad Irvin | Electrician |
| Anthony 'Spike' Simms | Rigging Gaffer |
| Paul Wilkowsky | Best Boy Grip |
| Steve Alessi | Grip |
| Brandon Cundiff | Grip |
| Spencer M. Rohan | Grip |
| Kevin Fannon | Grip |
| Tony Boura | Grip |
| Ronald Napier | Construction Foreman |
| Tina Tottis | Set Decoration Buyer |
| Ryan Gomez | First Assistant Accountant |
| Kelly Stultz | Payroll Accountant |
| M.K. Shaw | Payroll Accountant |
| Blair Miller | First Assistant Editor |
| Todd Toon | Sound Designer |
| Todd Toon | Supervising Sound Editor |
| Donald J. Malouf | Supervising Sound Editor |
| Donald J. Malouf | Sound Designer |
| Victoria Rose Sampson | Supervising ADR Editor |
| Charles W. Ritter | Sound Editor |
| John Kwiatkowski | Sound Editor |
| Odin Benitez | Sound Editor |
| Albert Gasser | Sound Editor |
| G.W. Brown | ADR Editor |
| Val Kuklowsky | ADR Editor |
| Pernell L. Salinas | First Assistant Sound Editor |
| Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Joe Barnett | Additional Sound Re-Recording Mixer |
| Darrin Mann | Foley Mixer |
| Catherine Harper | Foley Artist |
| Christopher Moriana | Foley Artist |
| Greg Steele | ADR Mixer |
| Robert Deschaine | ADR Mixer |
| Ron Bedrosian | ADR Mixer |
| Dean St. John | ADR Mixer |
| Doc Kane | ADR Mixer |
| Greg Zimmerman | ADR Recordist |
| Tami Treadwell | ADR Recordist |
| Julio Carmona | ADR Recordist |
| Julie Altus | ADR Recordist |
| Marcus Trumpp | Additional Music |
| Brandon Roberts | Additional Music |
| Dennis Smith | Additional Music |
| John Paesano | Additional Music |
| Ben Schor | Music Editor |
| Leeba Zakharov | Casting Associate |
| Sabrina Hyman | Casting Associate |
| Charles L. Gariepy | Casting Associate |
| Andy Henry | Casting Associate |
| Carl S.G. Moore | Digital Intermediate Producer |
| Mark Sahagun | Digital Intermediate Editor |
| Bruce Schluter | Title Designer |
| Jon Cowley | VFX Supervisor |
| Keith Devlin | Compositing Supervisor |
| Mathew Giampa | Compositor |
| Trevor Strand | Compositor |
| Kurt Braun | Set Dresser |
| Sarah Ivey | Set Dresser |
| Mark Sejnowski | Set Dresser |
| Michael D'Sa | Visual Effects Producer |
| Shome Dasgupta | Visual Effects Producer |
| Jamison Scott Goei | Visual Effects Supervisor |
| Arushi Govil | VFX Artist |
| Reupal D Rawal | Visual Effects Supervisor |
| Dane Farwell | Stunts |
