 | Nathan Fillion als Malcolm "Mal" Reynolds |
 | Summer Glau als River Tam |
 | Gina Torres als Zoë Alleyne Washburne |
 | Alan Tudyk als Hoban "Wash" Washburne |
 | Morena Baccarin als Inara Serra |
 | Adam Baldwin als Jayne Cobb |
 | Jewel Staite als Kaywinnet Lee "Kaylee" Frye |
 | Sean Maher als Simon Tam |
 | Ron Glass als Shepherd Derrial Book |
 | Chiwetel Ejiofor als The Operative |
 | David Krumholtz als Mr. Universe |
 | Michael Hitchcock als Dr. Mathias |
 | Sarah Paulson als Dr. Caron |
 | Yan Feldman als Mingojerry "Mingo" Rample |
 | Rafael Feldman als Fantastic "Fanty" Rample |
 | Nectar Rose als Lenore |
 | Tamara Taylor als Teacher |
 | Glenn Howerton als Lilac Young Tough |
 | Hunter Ansley Wryn als Young River Tam |
| Logan O'Brien als Boy Student |
| Erik Erotas als Boy Student |
| Demetra Raven als Girl Student |
 | Marley McClean als Girl Student |
| Jessica Huang als Girl Student |
 | Scott Kinworthy als Ensign |
 | Erik Weiner als Helmsman |
| Conor O'Brien als Lab Technician |
 | Peter James Smith als Lab Technician |
 | Weston Nathanson als Trade Agent |
| Carrie "CeCe" Cline als Young Female Intern |
| Chuck O'Neil als Vault Guard |
 | Amy Wieczorek als Lilac Mom |
 | Tristan Jarred als Lilac Son |
| Elaine Mani Lee als Fan Dancer |
 | Terrence Hardy Jr. als Mining Camp Boy |
| Brian O'Hare als Alliance Pilot |
 | Ryan Tasz als Black Room Soldier |
 | Colin Patrick Lynch als Black Room Soldier |
 | Terrell Tilford als News Anchor |
| Joshua Michael Kwiat als Slovenly Beaumonde Man |
| Antonio Rufino als Bartender (uncredited) |
 | Linda Wang als Chinese Snake Dancer (uncredited) |
| Rick Williamson als Bar Guy (uncredited) |
 | Neil Patrick Harris als Screaming Reaver (uncredited) |
 | Matt McColm als Lab Security (uncredited) |
 | Marcus Young als Bar Security (uncredited) |
 | Dennis Keiffer als Bar Guy (uncredited) |
| Joss Whedon | Director |
| Joss Whedon | Author |
| Barry Mendel | Producer |
| Christopher Buchanan | Executive Producer |
| David V. Lester | Executive Producer |
| Alisa Tager | Executive Producer |
| Joss Whedon | Writer |
| Lisa Lassek | Editor |
| Barry Chusid | Production Design |
| Anya Colloff | Casting |
| Amy McIntyre Britt | Casting |
| Ruth E. Carter | Costume Design |
| Camille Calvet | Makeup Department Head |
| Daniel T. Dorrance | Art Direction |
| Larry Dias | Set Decoration |
| Jim Johnson | Set Decoration |
| Tim Rigby | Stunts |
| Jack N. Green | Director of Photography |
| Jennifer Bell | Hairstylist |
| Scott Stoddard | Makeup Supervisor |
| Vickie Mynes | Hairstylist |
| Sean Flanigan | Key Hair Stylist |
| Mary Kay Morse | Key Makeup Artist |
| Christopher Allen Nelson | Key Makeup Artist |
| Garrett Immel | Key Makeup Artist |
| Tina Hoffman | Makeup Artist |
| Karen Iverson | Makeup Artist |
| Margie Kaklamanos | Makeup Artist |
| Ron Pipes | Makeup Artist |
| Carla S. Nemec | Art Department Coordinator |
| Lisa D. DiSanto | Art Department Coordinator |
| Kevin Kavanaugh | Assistant Art Director |
| Gerald Sullivan | Assistant Art Director |
| Robert A. Blackburn | Construction Coordinator |
| Brad Einhorn | Property Master |
| Mary E. Manning | 3D Artist |
| Fumi Mashimo | Animation Supervisor |
| Emile Edwin Smith | CG Supervisor |
| Karl Herbst | Digital Effects Supervisor |
| Bud Myrick | Digital Effects Supervisor |
| Rpin Suwannath | Pre-Visualization Supervisor |
| Patrick D. Hurd | Visual Effects Coordinator |
| James Turek | Visual Effects Coordinator |
| Susie Brubaker | Visual Effects Coordinator |
| Collin Fowler | Visual Effects Coordinator |
| Stephanie Pollard | Visual Effects Coordinator |
| Chris Anderson | Visual Effects Coordinator |
| Thomas Elder-Groebe | Visual Effects Coordinator |
| Eric Withee | Visual Effects Coordinator |
| Steve Pimental | Visual Effects Coordinator |
| J.P. "Brendan" Bernardo | Visual Effects Editor |
| Josh Margolies | Visual Effects Editor |
| Juliette Yager | Visual Effects Producer |
| Gary Nolin | Visual Effects Producer |
| Catherine Sudolcan | Visual Effects Producer |
| Lisa Goldberg | Visual Effects Producer |
| Les Hunter | Visual Effects Producer |
| Loni Peristere | Visual Effects Supervisor |
| Dan DeLeeuw | Visual Effects Supervisor |
| Richard Malzahn | Visual Effects Supervisor |
| Randy Goux | Visual Effects Supervisor |
| John K. Stirber | Special Effects Supervisor |
| Daniel Sudick | Special Effects Coordinator |
| David B. Nowell | Aerial Director of Photography |
| George Lozano Jr. | Best Boy Electric |
| Andrew Shulkind | Camera Operator |
| Ryan Green | Camera Operator |
| Raymond Stella | Second Unit Director of Photography |
| Mark Emery Moore | Steadicam Operator |
| Gary Tandrow | Chief Lighting Technician |
| Sean Devine | Dolly Grip |
| Brad Boyer | Dolly Grip |
| John Davies | Electrician |
| Chris Pavlu | Electrician |
| Jason Young | Electrician |
| Peter N. Green | First Assistant Camera |
| Tony Olivieri | First Assistant Camera |
| Jerry C. Deats | Key Grip |
| Greg Karamov | Key Grip |
| Rex Anson Rhorer | Rigging Grip |
| Justin Van Fleet | Rigging Grip |
| Minh Bahnsen | Rigging Grip |
| Sidney Ray Baldwin | Still Photographer |
| Paul Murphey | Video Assist Operator |
| Jain Sekuler | Script Supervisor |
| Thomas Terry | Pilot |
| Stephanie Flack | ADR Editor |
| Gail Carroll-Coe | Boom Operator |
| Timothy P. Salmon | Boom Operator |
| Lou Kleinman | Dialogue Editor |
| Michael Magill | Dialogue Editor |
| Gwendolyn Yates Whittle | Dialogue Editor |
| John Cannon | First Assistant Sound Editor |
| John Roesch | Foley |
| Craig S. Jaeger | Foley Editor |
| Kerry Ann Carmean | Sound Effects Editor |
| David A. Whittaker | Sound Effects Editor |
| Ben Wilkins | Sound Effects Editor |
| Hector C. Gika | Sound Effects Editor |
| Karen Vassar Triest | Sound Effects Editor |
| Eric Flickinger | Sound Recordist |
| Ron Bartlett | Sound Re-Recording Mixer |
| Mark Smith | Sound Re-Recording Mixer |
| Tom Bellfort | Supervising Sound Editor |
| Geoffrey G. Rubay | Supervising Sound Editor |
| Ryck Schmidt | Ager/Dyer |
| Jordanna Fineberg | Assistant Costume Designer |
| Dana Kay Hart | Costume Supervisor |
| Daniel Dirks | Key Costumer |
| Monica Haynes | Key Costumer |
| Sari Knight | Casting Associate |
| John Nicolard | Digital Intermediate |
| Bill Schultz | Digital Intermediate |
| Walter Volpatto | Digital Intermediate |
| Catherine Chase | First Assistant Editor |
| Mo Henry | Negative Cutter |
| Aidan Stanford | Color Timer |
| Dan Muscarella | Color Timer |
| Lauren Ross | Location Manager |
| Scott Wesley Ross | Assistant Editor |
| David Newman | Original Music Composer |
| Virginia Landis Albertson | Post Production Supervisor |
| David V. Lester | Unit Production Manager |
| Rich Sickler | First Assistant Director |
| Pedro Barquin | Greensman |
| Harald Belker | Production Illustrator |
| P. Scott Bailey | Leadman |
| Shawn Albro | Painter |
| Mark Bialuski | Propmaker |
| Jaremy Aiello | Sculptor |
| Kelly Berry | Set Decoration Buyer |
| Mick Cukurs | Set Designer |
| Courtney J. Andersen | Set Dressing Artist |
| Chuck Eskridge | Standby Painter |
| Andrew Bock | Assistant Sound Editor |
| Art Rochester | Sound Mixer |
| Ron Petruccione | Special Effects |
| Scott Burrows | Compositor |
| Marcus Stokes | Sequence Supervisor |
| Justin Ball | Systems Administrators & Support |
| L. Patrick McCormack | Visual Effects |
| Chad Stahelski | Stunt Coordinator |
| Hank Amos | Stunts |
| Regina McKee Redwing | Utility Stunts |
| Jesse Jaraczewski | Best Boy Electric |
| Steven A. Guerrero | Grip |
| James M. Cox | Rigging Gaffer |
| James Dornoff | Editorial Production Assistant |
| Jeff Carson | Music Editor |
| Norman Ludwin | Musician |
| Gregory Jamrok | Orchestrator |
| Jack Carpenter | Driver |
| Eric Compton | Transportation Captain |
| Donald R. Casella | Transportation Coordinator |
| Mary King | Craft Service |
| Sophia Lansky | Dialect Coach |
| Louis Farah | Set Medic |
| James Maull | Post Production Accountant |
| Mary Sunshine | Production Accountant |
| Christina Rollo | Production Coordinator |
| Sage Asteak | Set Production Assistant |
| Elizabeth Cameron | Stand In |
| Rob Harris | Unit Publicist |
| Helen Wilson | Props |
| Pilar Harlow | Contact Lens Technician |
| Robert Miller | Costume Illustrator |
| Steve Constancio | Costumer |
| Maria Battle Campbell | Second Second Assistant Director |
| Shaun O'Dell | Second Unit Director |
| James Lee Kroning | Assistant Property Master |
| Matt Codd | Concept Artist |
| Jarik Van Sluijs | Creative Director |
| Trey Shaffer | Graphic Designer |
| Chad Koch | Set Decorating Coordinator |
| Joey Genitempo | Set Painter |
| Julia Gombert | Textile Artist |
| Gary Hebert | Title Designer |
| Eric Gotthelf | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Alyson Dee Moore | Foley Artist |
| Mary Jo Lang | Foley Mixer |
| Scott Morgan | Foley Recordist |
| Christopher Flick | Foley Supervisor |
| Roy Augenstein | Special Effects Technician |
| Jacqueline Cooper | VFX Artist |
| John Peter Bernardo | Visual Effects Editor |
| Karin Silvestri | Stunt Double |
| Chris Palermo | Stunt Driver |
| Mark Colicci | Assistant Camera |
| Jeffrey A. Johnson | Best Boy Grip |
| Lynda Wu | Camera Loader |
| Heather Green | Second Assistant Camera |
| Carrie Levin | Casting Assistant |
| Patrick J. Barry | Assistant Editor |
| Greg Curry | Colorist |
| Anthony Harris | Digital Color Timer |
| John Daro | Digital Intermediate Editor |
| David Newman | Conductor |
| Amanda Crockett | Art Department Production Assistant |
| Mark Asaro | Assistant Production Coordinator |
| Patti Gannon | Compositing Supervisor |
| Achint Bansal | Digital Compositor |
| Richard Patterson | Digital Supervisor |
| Sasha Adkinson | Extras Casting |
| Judy Cook | Extras Casting Assistant |
| Jill Rosenblatt | First Assistant Accountant |
| Melissa Huerta | Intern |
| Mollie Stallman | Key Production Assistant |
| Robert Dudley | Key Rigging Grip |
| Blake Perkinson | Key Set Production Assistant |
| Michael Lloyd | Matte Painter |
| David Hickey | Payroll Accountant |
| Adam Balentine | Production Assistant |
| Julia M. Sauder | Production Secretary |
| Jennifer Clark | Second Assistant Accountant |
| J.J. Perry | Stunt Double |
| Sonja Munsterman | Stunts |
| David Leitch | Stunts |
| Samuel Le | Stunts |
| Henry Kingi Jr. | Stunts |
| Jeff Imada | Stunts |
| Scott Cosgrove | Stunts |
| John C. Meier | Stunts |
| Tim Trella | Stunts |
| Steve Upton | Stunts |
| Tyler Vogt | Stunts |
| Ming Qiu | Stunts |
| Casey Pieretti | Stunts |
| Michael Hugghins | Stunts |
| David Hugghins | Stunts |
| Yuri Hinson | Stunts |
| Clay Donahue Fontenot | Stunts |
| Ray Harvie | Storyboard Artist |
| Adam 'Mojo' Lebowitz | Visual Effects |
| David R. Morton | Matte Painter |
| Heidi Moneymaker | Stunts |
| David Williams | Dialogue Editor |
| Matt McColm | Stunts |
| Darrin Prescott | Stunts |
| Tommy J. Huff | Stunts |
