 | Cuba Gooding Jr. als Mikey |
 | Helen Mirren als Rose |
 | Vanessa Ferlito als Vicki |
 | Macy Gray als Neisha |
 | Joseph Gordon-Levitt als Dr. Don |
 | Stephen Dorff als Clayton Mayfield |
 | Mo'Nique als Precious |
 | Tom Pasch als Andrew |
| Ryan Eric Speise als Anthony - Age 3 |
| Matt Higgins als Eddie |
| John Panzarella als Man in Hotel |
 | Marvina Vinique als Mikey's Mother |
| Marilyn Yoblick als Real Estate Agent |
| Cullen Flynn Clancy als Anthony - age 7 |
| Shaun Brewington als Little Mikey |
| Darnell Williams als Mikey's Father |
| Noel Murano als A.J. |
 | Angel Oquendo als Lamar |
| Tomy Dunster als Gerard |
 | Jack Krizmanich als Tommy |
 | Maria Soccor als Clayton's Girlfriend |
| Will Rokos | Writer |
| Chryss Hionis | Set Decoration |
| Lisa Cortés | Producer |
| Lee Daniels | Producer |
| Tucker Tooley | Executive Producer |
| William Chang Suk-Ping | Editor |
| Diane Heery | Casting |
| Kerry Barden | Casting |
| Damon Dash | Producer |
| Brian A. Kates | Editor |
| Dawn Lenfest | Executive Producer |
| Suzanne Smith Crowley | Casting |
| Lee Daniels | Director |
| Mario Grigorov | Original Music Composer |
| M. David Mullen | Director of Photography |
| Steve Saklad | Production Design |
| Billy Hopkins | Casting |
| Brook Lenfest | Producer |
| Tim Galvin | Art Direction |
| Leah Daniels Butler | Casting |
| David Robinson | Producer |
| Teresa Binder Westby | Costume Design |
| Kelly Gleason | Makeup Department Head |
| Brian Badie | Hair Department Head |
| Eden Daniels | Assistant Costume Designer |
| David Taicher | Steadicam Operator |
| Meghan Keener | Art Department Coordinator |
| Michael Leonard | First Assistant Camera |
| Barney Burman | Makeup Effects |
| Anthony Pettine | Script Supervisor |
| Kevin Fanning | Visual Effects Supervisor |
| Stephen Prouty | Makeup Effects |
| Simone Sheffield | Co-Producer |
| William Louthe | Electrician |
| Shelly Earl | Animal Wrangler |
| Branka Mrkic | Dialogue Editor |
| David Brandon | Electrician |
| Valerie Hoffman | Co-Producer |
| Marko Costanzo | Foley |
| Jamie Baker | Foley Editor |
| Benjamin Cheah | Sound Re-Recording Mixer |
| Paul Hsu | Sound Effects Editor |
| Kris Magyarits | Title Designer |
| Larry Wineland | Sound Effects Editor |
| Jason Loftus | Casting Associate |
| Billy Stearne | Set Dresser |
| Sean Garnhart | Sound Effects Editor |
| Kara Morasco | Tailor |
| Jacqueline Noel | Hairstylist |
| Scott Edelson | Boom Operator |
| Joseph Farulla | Key Makeup Artist |
| Jolie Scherberger | Set Dresser |
| Tierre Turner | Stunt Coordinator |
| Richard A. Mitchell | Electrician |
| Barbara Hause | Wardrobe Supervisor |
| Ben Noble | Best Boy Electric |
| Lindsay Irish-Desarno | Makeup Artist |
| Benjamin Cheah | Supervising Sound Editor |
| David Lee | Still Photographer |
| Brian A. Kates | Music Editor |
| A.J. Azzarto | Music Supervisor |
| R. Vincent Smith | Property Master |
| Kevin Janicelli | Gaffer |
| Mike Poppleton | Foley Editor |
| Brad Heiner | Key Grip |
| Gregory F. Johnson | Rigging Grip |
| A.J. Lambert | Music Supervisor |
