 | Marlene Dietrich als Shanghai Lily |
 | Clive Brook als Captain Donald 'Doc' Harvey |
 | Anna May Wong als Hui Fei |
 | Warner Oland als Mr. Henry Chang |
 | Eugene Pallette als Sam Salt |
 | Lawrence Grant als Reverend Carmichael |
 | Louise Closser Hale als Mrs. Haggerty |
 | Gustav von Seyffertitz als Eric Baum |
 | Émile Chautard als Major Lenard |
 | George Blagoi als Minor Role (uncredited) |
 | Leonard Carey als Carey (uncredited) |
 | George Chung als Chinese Soldier (uncredited) |
| Wong Chung als Chinese Officer Checking Passports (uncredited) |
| Jack Deery als British Officer at Shanghai (uncredited) |
 | Herbert Evans als British Railway Officer (uncredited) |
 | Willie Fung als Train Engineer (uncredited) |
| Tom Gubbins als Chinese Officer (uncredited) |
 | Forrester Harvey als Peiping Ticket Agent (uncredited) |
 | Claude King als Mr. Albright (uncredited) |
 | James B. Leong als A Rebel (uncredited) |
 | Miki Morita als Chinese Officer (uncredited) |
| Minoru Nishida als Li Fung (uncredited) |
 | Victor Wong als Chinese Officer (uncredited) |
| Ura Mita als Chinese Woman (uncredited) |
| Josef von Sternberg | Director |
| Travis Banton | Costume Design |
| Jules Furthman | Screenplay |
| Lee Garmes | Director of Photography |
| Harry Hervey | Story |
| Adolph Zukor | Executive Producer |
| Frank Sullivan | Editor |
| Hans Dreier | Art Direction |
| Karl Hajos | Original Music Composer |
| W. Franke Harling | Original Music Composer |
| Rudolph G. Kopp | Original Music Composer |
| John Leipold | Original Music Composer |
| James Wong Howe | Additional Photography |
| Richard Kollorsz | Set Designer |
| Harry D. Mills | Sound |
| Milton Bridenbecker | Assistant Camera |
| Roy Clark | Second Assistant Camera |
| Warner Cruze | Assistant Camera |
| Otto Dyar | Still Photographer |
| Don English | Still Photographer |
| Junius Estep | Still Photographer |
| Daniel L. Fapp | Second Assistant Camera |
| Warren Lynch | Second Assistant Camera |
| Homer Plannette | Gaffer |
| Travis Banton | Costumer |
| René Hubert | Costumer |
| Herman Hand | Orchestrator |
| Adolph Zukor | Presenter |
| Tom Gubbins | Technical Advisor |
