 | Robert Downey Jr. als Sherlock Holmes |
 | Jude Law als Dr. John Watson |
 | Jared Harris als Professor James Moriarty |
 | Eddie Marsan als Inspector Lestrade |
| Arthur Conan Doyle | Characters |
| Susan Downey | Producer |
| Chris Brancato | Screenplay |
| Dan Lin | Producer |
| Joel Silver | Producer |
| Lionel Wigram | Producer |
| Bruce Berman | Executive Producer |
| Paul D. Austerberry | Production Design |
