 | Robert Downey Jr. als Sherlock Holmes |
 | Jude Law als Dr. John Watson |
 | Noomi Rapace als Madam Simza Heron |
 | Jared Harris als Professor James Moriarty |
 | Rachel McAdams als Irene Adler |
 | Eddie Marsan als Inspector Lestrade |
 | Kelly Reilly als Mary Morstan |
 | Stephen Fry als Mycroft Holmes |
 | Paul Anderson als Colonel Sebastian Moran |
 | Geraldine James als Mrs. Hudson |
 | William Houston als Constable Clark |
 | Wolf Kahler als Doctor Hoffmanstahl |
 | Iain Mitchell als Auctioneer |
 | Jack Laskey als Carruthers |
 | Patricia Slater als Shush Club Maitre D' |
 | Karima McAdams als Shush Club Maitre D' |
 | Richard Cunningham als Businessman |
 | Marcus Shakesheff als Hashisheen |
 | Mark Sheals als Cock Fight Referee |
 | George Taylor als University Student |
 | Michael Webber als Vicar |
 | Mike Grady als Train Conductor |
| Alexandre Carril als Twin |
| Victor Carril als Twin |
 | Thorston Manderlay als Alfred Meinhard |
 | Affif Ben Badra als Tamas |
 | Daniel Naprous als Marko |
 | Lancelot Weaver als Stefan |
 | Vladimir "Furdo" Furdik als Andrzej |
 | Alexander Devrient als Gypsy |
 | Fatima Adoum als Gypsy |
 | Stanley Kaye als Stanley |
 | Thierry Neuvic als Claude Ravache |
 | Martin Nelson als Commendatore |
 | Mark Llewelyn-Evans als Don Giovanni |
 | Anthony Inglis als Conductor |
 | Ian Wilson-Pope als Leporello |
 | Pamela Hay als Elvira |
 | Laurence Dobiesz als Servant |
 | Peter Stark als German Officer |
 | Roman Jankovič als German Officer |
 | Fredrick Ruth als Ballroom Attendant |
 | Carsten Hayes als Ballroom Photographer |
 | Jonathan Christie als Diplomat |
 | James McNeill als Diplomat |
 | Laurentiu Possa als Rene Heron |
 | Maitland Chandler als Banker |
 | Joe Egan als Big Joe |
 | Clive Russell als Captain Tanner |
 | Sala Baker als Adler's Escort (uncredited) |
| Alison Harvey | Set Decoration |
| Katie Spencer | Set Decoration |
| Sirio Quintavalle | Visual Effects Supervisor |
| Jenny Beavan | Costume Design |
| Mark Holt | Special Effects Coordinator |
| Reg Poerscout-Edgerton | Casting |
| Joel Silver | Producer |
| Peter Burgis | Foley |
| Nina Armstrong | Stunts |
| Chas Jarrett | Visual Effects Supervisor |
| Guy Ritchie | Director |
| Kieran Mulroney | Screenplay |
| Philippe Rousselot | Director of Photography |
| Steve Clark-Hall | Executive Producer |
| Nick Gottschalk | Art Direction |
| Mark Henson | Stunt Coordinator |
| Netty Chapman | Art Direction |
| Bruce Berman | Executive Producer |
| Sarah Greenwood | Production Design |
| Matthew Gray | Art Direction |
| Michele Mulroney | Screenplay |
| Markos Rounthwaite | Stunt Coordinator |
| Hans Zimmer | Original Music Composer |
| Dan Lin | Producer |
| Lionel Wigram | Producer |
| Susan Downey | Producer |
| James Herbert | Editor |
| James Foster | Art Direction |
| Niall Moroney | Supervising Art Director |
| Arthur Conan Doyle | Characters |
| Elizabeth West | Script Supervisor |
| Mark Mostyn | Unit Production Manager |
| Kevin Kaska | Orchestrator |
| Maxime Couteret | Location Manager |
| Michael Connell | Music Editor |
| Lisa Davidson | Production Coordinator |
| Emma Zee | Post Production Supervisor |
| Charlie Somers | Location Manager |
| Lauren Meek | Co-Producer |
| Kelsey Wheeler | Pilot |
| Emma Callinan | Casting Assistant |
| Peter Eskelsen | Associate Producer |
| Elodie Demey | Casting |
| Karen Elliott | Music Supervisor |
| Katherine Tibbetts | Production Coordinator |
| Ethan Erwin | Co-Producer |
| Charlotte Wright | Location Manager |
| Michael Higham | Music Editor |
| Giles Edleston | Location Manager |
| Remo Tozzi | Set Designer |
| Bashaar Wahab | Location Scout |
| Arnaud Kaiser | Location Manager |
| Agnes Bermejo | Production Coordinator |
| Alasdair Willson | Title Designer |
| Alex Gladstone | Location Manager |
| Peter Oso Snell | Music Editor |
| Andrew Purdy | Lighting Technician |
| Christine Blundell | Hair Designer |
| Mark Taylor | Sound Re-Recording Mixer |
| Henry Badgett | 2D Supervisor |
| Sara Trezzi | Visual Effects Producer |
| Seth Maury | Visual Effects Supervisor |
| Todd Kleparski | Digital Intermediate |
| Sam Bollinger | Assistant Editor |
| Julian Morson | Camera Operator |
| Nikita Rae | Makeup Artist |
| Marco Scotti | Costume Supervisor |
| Pawl Fulker | Pre-Visualization Supervisor |
| Charlotte Nelson | Visual Effects Coordinator |
| Richard Merrell | Electrician |
| Adrian Rigby | Makeup Artist |
| Becki Ponting | Supervising Dialogue Editor |
| Doug Oddy | Visual Effects Producer |
| Adam Dale | Aerial Director of Photography |
| Liberty Haynes | Makeup Artist |
| Lesa Warrener | Makeup Artist |
| Sally Turner | Assistant Costume Designer |
| Simon Chase | Dialogue Editor |
| Oliver Tarney | Supervising Sound Editor |
| Jennifer-Jo Barker | Visual Effects Coordinator |
| Lucy Drewett | Visual Effects Coordinator |
| Peter Wignall | Steadicam Operator |
| Terry Williams | Key Grip |
| Chloe Meddings | Hairstylist |
| Laura Lilley | Hairstylist |
| Lora E. Revitt | Costume Illustrator |
| Andrea Pirisi | VFX Editor |
| Miles Barry | Visual Effects Editor |
| Dominic Thomson | Digital Intermediate |
| Andy Bell | Best Boy Electric |
| Nigel Permane | Camera Operator |
| Dave Marriott | Electrician |
| Steve Wood | Lighting Technician |
| Jenny Hammond | Makeup Artist |
| Clare Spragge | Costume Supervisor |
| Tristan Tarrant | Boom Operator |
| Martin Cantwell | Foley Editor |
| Jennifer Fairweather | Visual Effects Coordinator |
| James Greig | Visual Effects Coordinator |
| Leona Naidoo | Visual Effects Editor |
| Philip Hedgecock | First Assistant Editor |
| Steve Pugh | Key Grip |
| Catherine Davies | Hairstylist |
| Sarah Downes | Makeup Artist |
| Mohamed Sobhy | CG Supervisor |
| Laya Armian | Visual Effects Producer |
| Zai Ortiz | Visual Effects Supervisor |
| Dave Brennan | Electrician |
| Chuck Finch | Gaffer |
| Will Finch | Lighting Technician |
| Davina Lamont | Makeup Artist |
| Claire Matthews | Makeup Artist |
| Oliver Tarney | Sound Designer |
| Mark Moriarty | Camera Operator |
| Stuart Godfrey | Dolly Grip |
| Soleil Jackson | Hairstylist |
| Nuria Mbomio | Hairstylist |
| Charmaine Fuller | Hair Supervisor |
| François-Louis Delfolie | Costume Supervisor |
| Marco de Magalhães | Key Costumer |
| Gary Dodkin | Boom Operator |
| Jason Swanscott | Foley |
| Harold Parker | Assistant Editor |
| Christopher Raphael | Additional Still Photographer |
| Mike Parsons | Electrician |
| Dan Fontaine | Gaffer |
| Michele Barber | Makeup Artist |
| Steve Little | Dialogue Editor |
| Miso Ristov | 2D Supervisor |
| Mirek Suchomel | Visual Effects Coordinator |
| John Szebegyinszki | Visual Effects Coordinator |
| Agnes Legere | Hairstylist |
| Martin Mandeville | Costume Coordinator |
| Catherine Buyse Dian | Set Costumer |
| Ben White | CG Supervisor |
| Matt Adams | Digital Intermediate |
| Denise Kum | Hairstylist |
| Bunny Stanway-Mayers | Hairstylist |
| Chris Burdon | Sound Re-Recording Mixer |
| James Winnifrith | Visual Effects Editor |
| Mike Clark-Hall | Assistant Editor |
| Steve Ellingworth | Key Grip |
| Sarah Monfort | Key Costumer |
| James Shannon | Dolby Consultant |
| Becki Ponting | Supervising ADR Editor |
| Mark Webb | Visual Effects Coordinator |
| Tom Partridge | Visual Effects Editor |
| Chris Plevin | Camera Operator |
| Daniel Smith | Still Photographer |
| Sarah Jane Marks | Hairstylist |
| Vanessa Baker | ADR Voice Casting |
| Sunita Singh | Costume Coordinator |
| Lucy Ainsworth-Taylor | Visual Effects Producer |
| Angela Barson | Visual Effects Supervisor |
| David Higgs | Second Unit Director of Photography |
| Vince McGahon | Steadicam Operator |
| Shawn White | Gaffer |
| Julia Wilson | Hairstylist |
| William Towers | Boom Operator |
| Natalie Lovatt | Visual Effects Coordinator |
| Sala Baker | Stunts |
| David Smith | Additional Photography |
| Steve Finn | Boom Operator |
| Elliot Scott | Draughtsman |
| Elliot Scott | Art Department Assistant |
| Michele Tandy | Finance |
| Gary Jopling | Assistant Art Director |
| Jackson Spidell | Stunts |
| Arran Topham | Stunts |
| Rocky Taylor | Stunts |
| Hiro Koda | Stunts |
| Rob Inch | Stunts |
| Katharine Arnold | Stunts |
| Ben Wright | Stunts |
| Helen Steinway Bailey | Stunts |
| Charles Ramsay | Stunts |
| Jason Hunjan | Stunts |
| Ben Dimmock | Stunts |
| Craig Frosty Silva | Stunts |
| Tom Rodgers | Stunts |
| Mark Archer | Stunts |
| Tony van Silva | Stunts |
| Roy Taylor | Stunts |
| Chad Stahelski | Stunt Coordinator |
| Adam Kirley | Stunts |
| Paul Howell | Stunts |
| Alexander Temmink | Stunts |
| Richard Ryan | Fight Choreographer |
| Bean Peel | Stunts |
| Jo McLaren | Stunts |
| Stuart Frift | Stunts |
| Gary Connery | Stunts |
| Nellie Burroughes | Stunts |
| Erol Mehmet | Stunts |
| Derek Lea | Stunts |
| Kyle Gardiner | Stunts |
| Holland Diaz | Stunts |
| Stuart Clark | Stunts |
| Juliette Cheveley | Stunts |
| Stephanie Lelievre | Stunts |
| Steen Young | Stunts |
| Stuart Nicol | Stunts |
| Kim McGarrity | Stunts |
| Richard Dymer | Stunts |
| Levan Doran | Stunts |
| Trevor Steedman | Stunts |
| Stephen Rutherford | Stunts |
| Dean Forster | Stunts |
| Neil Finnighan | Stunts |
| Annabel Canaven | Stunts |
| Sian Milne | Stunts |
| Peter Miles | Stunts |
| Casey Michaels | Stunts |
| C.C. Smiff | Stunts |
| Glenn Foster | Stunts |
| Andy Butcher | Stunts |
| Keir Beck | Stunts |
| Michele Laine | Stunts |
| Alex Huynh | Stunts |
| Richard Hansen | Stunts |
| Lee Bagley | Stunts |
| Curtis Rivers | Stunts |
| Ian Pead | Stunts |
| Bobby Holland Hanton | Stunts |
| Tony Christian | Stunts |
| Jamie Millington | Stunts |
| Paul Kennington | Stunts |
| Nick Hobbs | Stunts |
| Richard Bradshaw | Stunts |
| Andy Bennett | Stunts |
| Sean Adames | Stunts |
| Reg Wayment | Stunts |
| Andy Wareham | Stunts |
| Florian Robin | Stunts |
| David Newton | Stunts |
| Kai Martin | Stunts |
| Gary Kane | Stunts |
| Christopher Slaughter | Stunts |
| Matt Price | Stunts |
| Andrew L Phillips | Stunts |
| Jeremy Marinas | Stunts |
| Chris Manger | Stunts |
| Guy List | Stunts |
| Frank Henson | Stunts |
| David R. Grant | Stunts |
| William Willoughby | Stunts |
| Donna Williams | Stunts |
| John Street | Stunts |
| Stuart St. Paul | Stunt Coordinator |
| Andy Pilgrim | Stunts |
| Eric Oram | Fight Choreographer |
| Ray Nicholas | Stunts |
| James Embree | Stunts |
| Matt Da Silva | Stunts |
| Rob Cooper | Stunts |
| Lloyd Bass | Stunts |
| Lee Knight | Lighting Technician |
| Chad Stahelski | Second Unit Director |
