 | Rooney Mara als Emily Taylor |
 | Jude Law als Jonathan Banks |
 | Catherine Zeta-Jones als Dr. Victoria Siebert |
 | Channing Tatum als Martin Taylor |
 | Vinessa Shaw als Dierdre Banks |
 | Ann Dowd als Mrs. Taylor |
 | Polly Draper als Eileen Spicer |
 | David Costabile als Carl |
 | Mamie Gummer als Kayla |
 | Scott Shepherd als NYPD Detective |
 | Marin Ireland als Upset Visitor |
 | Elizabeth Rodriguez als Pharmacist |
 | Craig muMs Grant als Wards Island Orderly |
 | Carmen Pelaez als Prison Desk Guard |
 | Peter Friedman als Banks' Partner #1 |
 | Laila Robins als Banks Partner #2 |
 | Haraldo Alvarez als Garage Attendant |
 | James Martinez als Police Officer at the Hospital |
 | Vladimir Versailles als Augustin |
 | Jacqueline Antaramian als Desk Nurse |
 | Michelle Vergara Moore als Joan |
 | Katie Lowes als Conference Organizer |
| Steven Platt als Bartender |
 | Victor Cruz als NYPD Officer Beahan |
 | Andrea Bogart als Drug Rep |
| Mitchell Michaeliszyn als Ezra Banks |
| Elizabeth Rich als Banks Patient #1 |
| Roderick Rodriguez als Paramedic #1 |
| Mark Weekes als Paramedic #2 |
 | Michael Nathanson als Assistant District Attorney |
 | Timothy Klein als Transporting Officer Kevin |
 | Sheila Tapia als Emily's Attorney |
 | Josh Elliott als GMA Anchor |
 | Sasha Bardey als Dr. Peter Joubert |
| Ashley Morrison als Reporter #1 |
| Steve Lacy als Reporter #2 |
 | Ken Marks als Banks Patient #2 |
 | Devin Ratray als Banks Patient #3 |
 | Russell G. Jones als Jeffrey Childs |
 | Munro M. Bonnell als Judge #1 |
 | Susan Gross als Susan |
 | Debbie Friedlander als Wards Island Administrator |
 | Ilyana Kadushin als ECT Patient |
 | Johnny Sanchez als ECT Nurse |
 | Nicole Ansari-Cox als Disturbed Patient on Phone |
 | LaChanze als Wards Island Desk Nurse |
 | Alice Niedermair als Wards Island Nurse |
 | Davenia McFadden als Judge |
| Ray DeBenedictis als Arresting Officer |
 | J. Claude Deering als Zach |
| Chevy Lamont Cofield als Reporter (uncredited) |
| Laurence Covington als Wards Island Patient (uncredited) |
| Barbara Ann Davison als Wards Island Patient (uncredited) |
 | Onika Day als Depressed Woman - Ablixa Commercial (uncredited) |
 | Brian Distance als Wards Medical Staff (uncredited) |
| John Farrer als Le Circ Restaurant Patron (uncredited) |
 | David Fierro als Wards Island Patient (uncredited) |
 | Rosemary Howard als Prison Visitor (uncredited) |
 | Peter Iasillo Jr. als Inmate (uncredited) |
 | Zivile Kaminskaite als Medical Conference Participant (uncredited) |
 | Peter Y. Kim als Young Stockbroker (uncredited) |
| Larissa Laurel als Pill Nurse (uncredited) |
| Sean Marrinan als Pedestrian (uncredited) |
 | Dylan Clark Marshall als Little Boy (uncredited) |
 | Elliott Mayer als Psych Ward Patient (uncredited) |
| Mario Moise Fontaine als Juror (uncredited) |
 | Nancy Nagrant als Intenin Drug Commercial Mom (uncredited) |
| Gil O'Brien als Pasta Lover Pedestrian (uncredited) |
 | Kerry O'Malley als Ward Psychiatrist (uncredited) |
| Greg Paul als Security Guard (uncredited) |
 | Anthony J. Ribustello als Desk Sergeant (uncredited) |
 | Alan R. Rodriguez als Police Officer (uncredited) |
| Hollie K. Seidel als Depressed Woman - Ablixa Commercial (uncredited) |
 | Kenneth Simmons als Agent (uncredited) |
| Blago Simon als Fundraiser Guest (uncredited) |
| Nikky Smedley als Policewoman at Gate (uncredited) |
 | Carol Stanzione als Freaky Poncho Patient (uncredited) |
 | Erica Faye Watson als Processing Nurse (uncredited) |
 | Aaron Roman Weiner als Cop (uncredited) |
| Steven Soderbergh | Director |
| Scott Z. Burns | Screenplay |
| Scott Z. Burns | Producer |
| Lorenzo di Bonaventura | Producer |
| Douglas Hansen | Executive Producer |
| Gregory Jacobs | Producer |
| Adi Shankar | Executive Producer |
| Spencer Silna | Executive Producer |
| Thomas Newman | Original Music Composer |
| Carmen Cuba | Casting |
| Susan Lyall | Costume Design |
| Steven Soderbergh | Director of Photography |
| Steven Soderbergh | Editor |
| Rena DeAngelo | Set Decoration |
| Miguel López-Castillo | Art Direction |
| Howard Cummings | Production Design |
| Kerrie Smith | Hair Department Head |
| Michelle Johnson | Key Hair Stylist |
| Nicki Ledermann | Makeup Department Head |
| Tania Ribalow | Key Makeup Artist |
| Cassandra Saulter | Makeup Artist |
| Sheyam Ghieth | Art Department Coordinator |
| Anne Goelz | Assistant Art Director |
| Barbra Matis | Assistant Art Director |
| Jill Alexander | Assistant Property Master |
| Paul Fletcher | Carpenter |
| Fred Piesco | Carpenter |
| Christopher Rovira | Carpenter |
| Paul Divone | Carpenter |
| Pierre Rovira | Construction Coordinator |
| Steve Gallo | Construction Grip |
| Bruce Jordan | Construction Grip |
| Kurt Rimmel | Construction Grip |
| Holly Watson | Graphic Designer |
| John J. Ciccimarro | Key Carpenter |
| Charlie Price | Key Construction Grip |
| Dick Tice | Leadman |
| Brad Einhorn | Property Master |
| Daniel Fisher | Property Master |
| Alyssa Motschwiller | Set Decorating Coordinator |
| Alfredo Viteri | Boom Operator |
| Matt Coby | Dialogue Editor |
| Aaron Glascock | Dialogue Editor |
| Dawn Fintor | Foley |
| Alicia Stevenson | Foley |
| Billy Theriot | Foley Editor |
| Scott Curtis | Foley Mixer |
| Larry Blake | Sound Re-Recording Mixer |
| Larry Blake | Supervising Sound Editor |
| Conrad V. Brink Jr. | Special Effects Coordinator |
| Thomas J. Smith | Visual Effects Supervisor |
| Rocco Palmieri | Best Boy Electric |
| Bob Izzo | Best Boy Grip |
| Patrick B. O'Brien | Camera Operator |
| Rob Agredo | Dolly Grip |
| Bob Gambardella | Electrician |
| Scott Maher | Electrician |
| Sean McCardell | Electrician |
| Peter Walts | Gaffer |
| Michael Fradianni | Genetator Operator |
| John Joseph Minardi | Key Grip |
| Kevin Murphy | Rigging Gaffer |
| John McEnerney | Key Rigging Grip |
| Barry Wetcher | Still Photographer |
| Wittney Horton | Casting Associate |
| Amy Ritchings | Assistant Costume Designer |
| Pashelle L. Latino | Costume Supervisor |
| Sandi Figueroa | Set Costumer |
| Trenee Clayton | Set Costumer |
| Olivia Barrand | Tailor |
| Dan Muscarella | Color Timer |
| John Daro | Digital Intermediate Colorist |
| Philip Beckner | Digital Intermediate Editor |
| Paul Lavoie | Digital Intermediate Producer |
| Bill Schultz | Digital Intermediate |
| David Rosenthal | Digital Intermediate |
| John Nicolard | Digital Intermediate |
| Corey Bayes | First Assistant Editor |
| Robert T. Striem | Location Manager |
| Brittany Rostron | Location Coordinator |
| Bill Bernstein | Music Editor |
| Howard Samuelsohn | Dialect Coach |
| Eva Z. Cabrera | Script Supervisor |
| Martin Connelly | Set Dresser |
| Nick Ferrara | Set Dresser |
| Gregory Jacobs | First Assistant Director |
| Jody Spilkoman | Second Assistant Director |
| G. A. Aguilar | Stunt Coordinator |
| Blaise Corrigan | Stunts |
| Josh Lakatos | Stunts |
| Nikki Brower | Stunt Double |
| Christopher Place | Stunts |
| Stephen A. Pope | Stunts |
| Declan Mulvey | Stunts |
| Victor Paguia | Stunts |
| Derrick Simmons | Stunts |
| Chris Cenatiempo | Stunts |
