 | LeBron James als LeBron James |
 | Don Cheadle als Al G. Rhythm |
 | Cedric Joe als Dominic 'Dom' James |
 | Jeff Bergman als Bugs Bunny / Sylvester / Yosemite Sam / Fred Flintstone (voice) |
 | Gabriel Iglesias als Speedy Gonzales (voice) |
 | Zendaya als Lola Bunny (voice) |
 | Eric Bauza als Daffy Duck / Porky Pig / Foghorn Leghorn / Elmer Fudd (voice) |
 | Candi Milo als Granny (voice) |
 | Bob Bergen als Tweety Bird (voice) |
 | Fred Tatasciore als Taz (voice) |
 | Anthony Davis als Anthony Davis / The Brow |
 | Damian Lillard als Damian Lillard / Chronos |
 | Klay Thompson als Klay Thompson / Wet-Fire |
 | Nneka Ogwumike als Nneka Ogwumike / Arachnneka |
 | Diana Taurasi als Diana Taurasi / White Mamba |
 | Sonequa Martin-Green als Kamiyah James |
 | Ceyair J Wright als Darius James |
 | Harper Leigh Alexander als Xosha James |
 | Khris Davis als Malik |
 | Xosha Roquemore als Shanice James |
| Stephen Kankole als Young LeBron (13 Years) |
 | Jalyn Hall als Young Malik (13 Years) |
 | Wood Harris als Coach C |
| Jordan Thomas als Young Boy |
 | Sue Bird als Sue Bird |
 | Draymond Green als Draymond Green |
 | A’ja Wilson als A’ja Wilson |
| Randy Mims als Barbershop Customer |
 | Gerald 'Slink' Johnson als Warner Bros. Security Guard |
 | Sarah Silverman als Warner Bros. Executive |
 | Steven Yeun als Warner Bros. Executive |
 | Ernie Johnson als Game Announcer |
 | Lil Rel Howery als Game Announcer |
 | Michael B. Jordan als Michael B. Jordan |
 | Rosario Dawson als Wonder Woman (voice) |
 | Justin Roiland als Rick Sanchez / Morty Smith (voice) |
 | Kimberly Brooks als Additional Voices (voice) |
| Ryan Coogler | Producer |
| Maverick Carter | Producer |
| Malcolm D. Lee | Director |
| Duncan Henderson | Producer |
| Justin Lin | Executive Producer |
| Sev Ohanian | Executive Producer |
| LeBron James | Producer |
| Jamal Henderson | Executive Producer |
| Tony Bancroft | Animation |
| Dan Haskett | Animation |
| Salvatore Totino | Director of Photography |
| Kris Bowers | Original Music Composer |
| Akin McKenzie | Production Design |
| Clint Wallace | Production Design |
| Bob Ducsay | Editor |
| Zinzi Coogler | Executive Producer |
| Allison Abbate | Executive Producer |
| Jesse Ehrman | Executive Producer |
| Spencer Beighley | Executive Producer |
| Terence Nance | Executive Producer |
| Ivan Reitman | Executive Producer |
| Kim Taylor-Coleman | Casting |
| Julien Pougnier | Art Direction |
| Eric Sundahl | Art Direction |
| Melisa Jusufi | Set Decoration |
| Howard Berger | Makeup Department Head |
| Jacenda Burkett | Makeup Artist |
| April M. Chaney | Makeup Artist |
| Prell Charusanti | Makeup Artist |
| Erin LeBre | Makeup Artist |
| Akiko Matsumoto | Makeup Artist |
| Jeni Novak | Makeup Artist |
| Chloe Sens | Makeup Artist |
| Johnny Villanueva | Hair Department Head |
| Jennifer Zide | Key Makeup Artist |
| Debbie Zoller | Makeup Artist |
| Erik Aadahl | Sound Designer |
| Erik Aadahl | Supervising Sound Editor |
| Malte Bieler | Sound Designer |
| Jason W. Jennings | Sound Designer |
| Brandon Jones | Sound Designer |
| Ethan van der Ryn | Sound Designer |
| Tim Walston | Sound Designer |
| Franklin Okike | Visual Effects |
| Cesar Rodriguez Bautista | Visual Effects |
| David Sheldon-Hicks | Visual Effects |
| De'Ann Power | Hairstylist |
| Melissa Bruning | Costume Design |
| Troy Nethercott | Producer |
| Kevin Martel | Animation Supervisor |
| Grady Cofer | Visual Effects Supervisor |
| Kier Lehman | Music Supervisor |
| Morgan Rhodes | Music Supervisor |
| Kimberly Nelson LoCascio | Co-Producer |
| R.J. Mino | Co-Producer |
| Keenan Coogler | Co-Producer |
| Kelley Robins Hicks | Co-Producer |
| Leo Benvenuti | Original Film Writer |
| Steve Rudnick | Original Film Writer |
| Timothy Harris | Original Film Writer |
| Herschel Weingrod | Original Film Writer |
| Juel Taylor | Story |
| Tony Rettenmaier | Story |
| Keenan Coogler | Story |
| Terence Nance | Story |
| Juel Taylor | Screenplay |
| Tony Rettenmaier | Screenplay |
| Keenan Coogler | Screenplay |
| Terence Nance | Screenplay |
| Jesse Gordon | Screenplay |
| Celeste Ballard | Screenplay |
| R.J. Mino | Unit Production Manager |
| Michael J. Moore | First Assistant Director |
| Rhys Summerhayes | Second Assistant Director |
| Spike Brandt | Animation Supervisor |
| Devin Crane | Animation Supervisor |
| Scott F. Johnston | Animation Director |
| Chris Cartagena | Other |
| Rene Mousseux | Stunt Coordinator |
| Doug Coleman | Stunt Coordinator |
| Michael J. Fisher | Stunt Coordinator |
| Terry Notary | Other |
| Joseph Bonn | Music Editor |
| Daniel Waldman | Music Editor |
| Ed Novick | Sound Mixer |
| Linda Whang | Makeup Artist |
| Steven E. Anderson | Makeup Artist |
| Anna P. McCarthy | Casting Associate |
| Dixie Webster | Extras Casting |
| Ethan van der Ryn | Supervising Sound Editor |
| Noëlle Raffaele | Visual Development |
| Mark Muñoz | Stunts |
| Max Bostic | Set Dresser |
| David Chow | Set Designer |
| Corey Gomez | Set Dresser |
| Tyrone Anthony Jones | Set Dresser |
| Tammy S. Lee | Set Designer |
| James Malley | Set Dresser |
| Sam Page | Set Designer |
| Nicholas Rymond | Set Dresser |
| Billy Sender | Set Dresser |
| Paul Sonski | Set Designer |
| Ella Thompson | Assistant Art Director |
| Heide Waldbaum | Assistant Art Director |
| Matt Cavanaugh | Sound Effects Editor |
| Chris Diebold | Sound Effects Editor |
| Michael Keller | Sound Re-Recording Mixer |
| Tim LeBlanc | Sound Re-Recording Mixer |
| Brandon Proctor | Sound Re-Recording Mixer |
| Greg ten Bosch | Sound Effects Editor |
| Alexandre Cancado | Visual Effects Supervisor |
| Whitney Coleman | Stunts |
| Leiki Veskimets | Production Manager |
| SZA | Songs |
| Shawn Kelly | Lead Animator |
