 | Michael Jai White als Al Simmons / Spawn |
 | Martin Sheen als Jason Wynn |
 | John Leguizamo als Clown / Violator |
 | Theresa Randle als Wanda Blake |
 | Nicol Williamson als Cogliostro |
 | D.B. Sweeney als Terry Fitzgerald |
 | Melinda Clarke als Jessica Priest |
 | Miko Hughes als Zack |
 | Sydni Beaudoin als Cyan |
 | Michael Papajohn als Glen, Zack's Dad |
 | Frank Welker als The Devil Malebolgia (voice) |
 | Tony Haney als African Liaison |
 | Todd McFarlane als Bum |
 | Simon Rhee als Hong Kong Military Air Base Person (uncredited) |
 | Robia LaMorte als XNN Reporter |
 | John Cothran als African Liaison |
| Caroline Gibson als News Anchor |
| Marc Robinson als Punk #1 |
 | Chris Coppola als Punk #2 |
 | Jay Caputo als Punk #3 |
| Darryl Warren als Security Guard |
 | Mike Akrawi als Foreign Dignitary #1 |
| Romeo Akrawi als Foreign Dignitary #2 |
 | Jack Coleman als Doctor |
 | Laura Interval als Angela (as Laura Stepp) |
| Garrison M. Singer als Anesthesiologist |
 | John Koyama als Hong Kong Military Air Base Security (uncredited) |
 | Al Goto als Hong Kong Military Air Base Person (uncredited) |
 | Roger Yuan als Korean Soldier (uncredited) |
| Angelie Almendare als Diplomat's Wife (uncredited) |
| Todd McFarlane | Author |
| Alan B. McElroy | Screenplay |
| Clint Goldman | Producer |
| Todd McFarlane | Executive Producer |
| Graeme Revell | Original Music Composer |
| Guillermo Navarro | Director of Photography |
| Todd Busch | Editor |
| Michael N. Knue | Editor |
| Mark A.Z. Dippé | Director |
| Bruce H. Newberg | Casting |
| Mary Jo Slater | Casting |
| Daniel J. Lester | Costume Design |
| Philip Harrison | Production Design |
| Dena Roth | Set Decoration |
| Richard Trus | Visual Effects |
| Eric W. Orbom | Art Direction |
| Cristina Patterson | Contact Lens Technician |
| Donna Cicatelli-Lewis | Key Makeup Artist |
| Cindy J. Williams | Makeup Artist |
| Cindy Cummins | Choreographer |
| Norman Cabrera | Special Effects Makeup Artist |
| Greg Funk | Special Effects Makeup Artist |
| Chris Hanson | Special Effects Makeup Artist |
| Joseph P. Lucky | Assistant Art Director |
| Ron Seigel | Assistant Property Master |
| John Bell | Concept Artist |
| Marc Gabbana | Concept Artist |
| Hajime Sorayama | Concept Artist |
| TyRuben Ellingson | Concept Artist |
| Robert A. Blackburn | Construction Coordinator |
| Robert Greenfield | Leadman |
| Mark Weissenfluh | Leadman |
| Ron Greenwood | Property Master |
| Fanée Aaron | Set Designer |
| Sharon E. Alshams | Set Designer |
| Dorn Merrill Kennison | Set Designer |
| Barry Lehrman | Set Designer |
| Richard F. Anderson | Set Dresser |
| P.K. MacCarthy | Storyboard Artist |
| Timothy James Kane | Assistant Camera |
| John Crimins | Best Boy Electric |
| Nathan Hathaway | Best Boy Electric |
| Allen D. Easton | Camera Operator |
| Jonathan Taylor | Second Unit Director of Photography |
| Dan Kneece | Steadicam Operator |
| Kenneth J. Appel | Electrician |
| Keith A. Hascher | Electrician |
| Evan A. Nesbitt | First Assistant Camera |
| David Lee | Gaffer |
| Rick Stribling | Key Grip |
| Kevin Brown | Lighting Technician |
| Derick Pritchard | Lighting Technician |
| Jeffrey De La Rosa | Rigging Gaffer |
| Marshall Valentine | Rigging Grip |
| Dennis J. Laine | Steadicam Operator |
| Peter Iovino | Still Photographer |
| Ray Patrick | Techno Crane Operator |
| Colin Cunningham | 3D Animator |
| Emiko Miki | Animation Director |
| James Straus | Animation Supervisor |
| Dennis Turner | Animation Supervisor |
| Nathalie Buce | Animation |
| Anders J.L Beer | Animation |
| Trish Schutz-Krause | Animation |
| Ian Hulbert | Animation |
| Matthew Talbot-Kelly | Animation |
| Mark Wendell | Animation |
| Richard Bennett | Background Designer |
| Constance Bracewell | CG Animator |
| Kelly Wilcox | CG Animator |
| Micheal Thomas Parks | CG Animator |
| Alan Barnett | Digital Effects Supervisor |
| Melissa Davies | Digital Effects Supervisor |
| Rudy Hassen | Digital Effects Supervisor |
| Ed Lee | Lighting Director |
| Toshiyuki Kimura | Matte Painter |
| Karen Klein | Roto Supervisor |
| Berj Bannayan | Software Engineer |
| Scott Leberecht | Visual Effects Art Director |
| Lance Wilhoite | Visual Effects Compositor |
| Susan Greenhow | Visual Effects Coordinator |
| Jeanmarie King | Visual Effects Coordinator |
| Stephanie Taylor | Visual Effects Coordinator |
| Sandra Almond | Visual Effects Producer |
| Bruce Jones | Visual Effects Producer |
| Tom C. Peitzman | Visual Effects Producer |
| Paul Patrick Quinn | Visual Effects Producer |
| Casey Cannon | Visual Effects Producer |
| Michele Maples | Visual Effects Producer |
| Jay Riddle | Visual Effects Supervisor |
| Steve 'Spaz' Williams | Visual Effects Supervisor |
| Jamie Dixon | Visual Effects Supervisor |
| David Biedny | Visual Effects Supervisor |
| Patrick Tatopoulos | Creature Design |
| Garry Elmendorf | Special Effects Supervisor |
| Linda Folk | ADR Editor |
| Damon Cohoon | Assistant Sound Editor |
| Bob Wishnefsky | Assistant Sound Editor |
| Bill Flick | Boom Operator |
| Scott Curtis | Foley Editor |
| Linda Di Franco | Foley Editor |
| Michael Dressel | Foley Editor |
| Shawn Kennelly | Foley Mixer |
| Eric Thompson | Foley Mixer |
| Brian Williams | Sound Designer |
| Jeffrey Kaplan | Sound Designer |
| Greg Hedgepath | Sound Editor |
| Solange S. Schwalbe | Sound Editor |
| Frank Smathers | Sound Editor |
| David E. Stone | Sound Editor |
| Paul Berolzheimer | Sound Effects Designer |
| Harry Cohen | Sound Effects Editor |
| Scott A. Jennings | Sound Effects Editor |
| Patricio A. Libenson | Sound Effects Editor |
| D. Chris Smith | Sound Effects Editor |
| Bruce Stubblefield | Sound Effects Editor |
| James Thornton | Sound Mixer |
| Liz Sroka | Sound Re-Recording Mixer |
| Steve Pederson | Sound Re-Recording Mixer |
| Dean Beville | Supervising Sound Editor |
| Jennifer Bender | Extras Casting |
| Winifred Kennamer | Set Costumer |
| Steve Ansell | Assistant Editor |
| Joëlle Taar | Assistant Editor |
| Neil Eric Wenger | Assistant Editor |
| Mike Mertens | Color Timer |
| Mike Sowa | Color Timer |
| Todd Busch | First Assistant Editor |
| Joe Fischer | Music Coordinator |
| Joshua Winget | Music Editor |
| Happy Walters | Music Supervisor |
| Tony Swatton | Armorer |
| Robin Anderson | Script Supervisor |
| Hilary Momberger-Powers | Script Supervisor |
| Kyle Cooper | Title Designer |
| Eric Smith | Title Designer |
| Deborah Wuliger | Unit Publicist |
| Harry Lu | Weapons Master |
| Chris David | Sound Re-Recording Mixer |
| Derek Thompson | Storyboard Artist |
| Mark Hicks | Stunts |
| Mark Hicks | Stunt Double |
| Jim Fitzpatrick | Sound Re-Recording Mixer |
| Faith Minton | Stunts |
| Kane Hodder | Stunts |
| Tony Brubaker | Stunts |
| Charles Croughwell | Stunt Coordinator |
| Denney Pierce | Stunts |
| Dane Farwell | Stunts |
| Debbie Lee Carrington | Stunts |
| Al Goto | Stunts |
| Tom Elliott | Stunt Double |
| Jeanie King | Visual Effects Coordinator |
| Jimmy Ortega | Stunts |
