 | Claire Danes als Yvaine |
 | Charlie Cox als Tristan Thorn |
 | Sienna Miller als Victoria |
 | Ricky Gervais als Ferdy the Fence |
 | Jason Flemyng als Primus |
 | Mark Strong als Septimus |
 | Rupert Everett als Secundus |
 | Peter O'Toole als King |
 | Michelle Pfeiffer als Lamia |
 | Robert De Niro als Captain Shakespeare |
 | Sarah Alexander als Empusa |
 | Melanie Hill als Ditchwater Sal |
 | Joanna Scanlan als Mormo |
 | Kate Magowan als Una / Slave Girl |
 | David Kelly als Guard |
 | Nathaniel Parker als Dunstan Thorn |
 | Dexter Fletcher als Skinny Pirate |
 | Henry Cavill als Humphrey |
 | David Walliams als Sextus |
 | Mark Heap als Tertius |
 | Mark Williams als Billy |
 | Ian McKellen als Narrator (voice) |
 | Adam Buxton als Quintus |
 | Bimbo Hart als Young Scientist |
| Alastair MacIntosh als Victorian Academic |
 | Ben Barnes als Young Dunstan Thorn |
 | Darby Hawker als Grumpy Customer |
 | Frank Ellis als Mr. Monday |
 | Struan Rodger als Bishop |
 | Julian Rhind-Tutt als Quartus |
 | George Innes als Soothsayer |
 | Jake Curran als Bernard |
 | Grant Burgin als Lackey |
 | Olivia Grant als Girl Bernard |
 | Eliot Sumner als Yvaine's Sister |
| Terry Murphy als Old Pirate |
 | Geoff Bell als Receptionist |
 | Mark Burns als New Bishop |
 | Rab Affleck als Pirate |
| Carlos Besse Peres als Pirate |
| Elwin 'Chopper' David als Pirate |
 | Adam Fogerty als Pirate |
 | Jordan Long als Pirate |
 | Spencer Wilding als Pirate |
| Stephen Marks | Executive Producer |
| Matthew Vaughn | Producer |
| Robert Cowper | Art Direction |
| Jane Goldman | Screenplay |
| Matthew Vaughn | Screenplay |
| Lorenzo di Bonaventura | Producer |
| Sammy Sheldon | Costume Design |
| Michael Dreyer | Producer |
| Neil Gaiman | Producer |
| Neil Gaiman | Novel |
| Lucinda Syson | Casting |
| Peter Young | Set Decoration |
| Peter Morton | Executive Producer |
| Chantal Feghali | Producer |
| Ben Davis | Director of Photography |
| Jon Harris | Editor |
| Matthew Vaughn | Director |
| Karen Sherriff-Brown | Makeup Artist |
| Rod McLean | Art Direction |
| Matthew Collinge | Sound Designer |
| Karen Sherriff-Brown | Hairstylist |
| Peter Wignall | Camera Operator |
| Paula Price | Hairstylist |
| Joanna Wright | Costume Supervisor |
| Nicole Young | Costume Supervisor |
| Gavin Bocquet | Production Design |
| Lavinia Waters | Art Department Coordinator |
| Chantal Feghali | Co-Producer |
| Simon Crane | Stunt Coordinator |
| Sue Westwood | Makeup Artist |
| Michael Maroussas | Dialogue Editor |
| Charlotte-Rose Kay | Assistant Costume Designer |
| Lesley Smith | Hairstylist |
| Daryl B. Kell | Music Editor |
| Liz Gallacher | Music Supervisor |
| Peter Chiang | Visual Effects Supervisor |
| Chris Brock | Unit Production Manager |
| Stuart Brisdon | Special Effects Supervisor |
| Joan Schneider | Production Coordinator |
| Piers Gielgud | Choreographer |
| Simon Hayes | Production Sound Mixer |
| Lesley Smith | Makeup Artist |
| James Gemmill | Scenic Artist |
| Ilan Eshkeri | Music |
| Sue Westwood | Hairstylist |
| Fae Hammond | Makeup Designer |
| James Grant | Location Manager |
| Miranda Jones | Post Production Supervisor |
| David Womark | Unit Production Manager |
| Peter Russell | Supervising Art Director |
| Julian Morson | Camera Operator |
| Tamsin Jeffrey | First Assistant Editor |
| Annie Penn | Script Supervisor |
| Nigel Nixon | Special Effects Supervisor |
| Kris Thykier | Executive Producer |
| Emma Pill | Location Manager |
| Michael Mooney | Assistant Costume Designer |
| Iain McFadyen | Art Direction |
| David Womark | Executive Producer |
| Tarquin Pack | Associate Producer |
| Steve Dent | Stunt Coordinator |
| Paula Price | Makeup Artist |
| Tim Porter | Unit Production Manager |
| Christopher Lloyd | Visual Effects Editor |
| Fae Hammond | Hair Designer |
| Ian Differ | Visual Effects Editor |
| Chris Burdon | Sound Re-Recording Mixer |
| David James | Still Photographer |
| Tim Field | Visual Effects Producer |
| Sam Conway | Special Effects Technician |
| Martin Harrison | First Assistant Director |
| Chris Stoaling | Second Assistant Director |
| Simon Crane | Second Unit Director |
| Danny Sheehan | Sound Supervisor |
| Heidi Gower | Third Assistant Director |
| Pamela Joyce | Production Coordinator |
| Terry Wells Sr. | Property Master |
| Fraser Taggart | Second Unit Director of Photography |
| Peter Burgis | Foley Artist |
| Andie Derrick | Foley Artist |
| Ed Colyer | Foley Recordist |
| Peter Gleaves | ADR Mixer |
| Mark Paterson | Sound Re-Recording Mixer |
| Les Fiddess | Foley Artist |
| Chris Lyons | Special Effects Makeup Artist |
| Matthew Smith | Prosthetic Makeup Artist |
| Tara McDonald | Makeup Artist |
| Shaune Harrison | Prosthetic Makeup Artist |
| Carol Hemming | Hairstylist |
| Barrie Gower | Prosthetic Makeup Artist |
| Nathaniel De'Lineadeus | Special Effects Makeup Artist |
| Stuart Bray | Prosthetic Makeup Artist |
| Maria Cork | Special Effects Makeup Artist |
