 | Melissa McCarthy als Carol Peters |
 | James Corden als Voice of Superintelligence / James Corden |
 | Bobby Cannavale als George Churchill |
 | Brian Tyree Henry als Dennis Caruso |
 | Sam Richardson als Agent John Donahue |
 | Ben Falcone als Agent Charles Kuiper |
 | Michael Beach als General Saul Gomez |
 | Rachel Ticotin als Director Tyson |
 | Jean Smart als President Monahan |
 | Sarah Baker als Emily |
 | Jessica St. Clair als Leslie |
 | Karan Soni als Ahmed |
 | Ken Griffey, Jr. als Ken Griffey, Jr. |
 | Octavia Spencer als Voice of Octavia Spencer (voice) |
 | William Daniels als Voice of KITT (voice) |
| Steve Mallory als Dean |
 | Courtney Patterson als Carla |
 | Usman Ally als Sergei |
| Jenna Perusich als Helga |
| Carolyn Trahan als Waitress Debbie |
 | Jay Lay als Jay |
| Mac Alsfeld als Fletcher Dobbs |
 | Damon Jones als Victor |
 | Eduardo Franco als Todd |
 | Patrick Bristow als Voice of Digital Superintelligence (voice) |
| Joanna Daniel als British Diplomat |
| Kristie Walden als Chinese Diplomat |
 | Ash Thapliyal als Indian Diplomat |
 | Mike Benitez als Restaurant Manager |
 | Jessie Ennis als Pedestrian |
| Judith Franklin als Mom |
 | Jakari Fraser als Son |
 | Charles Green als Motorcycle Cop |
| Tina Witherby als Usher |
 | Lu Parker als Anchorperson |
 | Vishesh Chachra als Army Tech Officer |
| Kami Bankston als Army Sergeant |
| Roberto C. Velazquez als Mariachi Singer |
| Luis Vazquez als Mariachi Singer |
| Jose T. Lara-Castro als Mariachi Singer |
| Ruben Velazquez als Mariachi Singer |
| Octavio Garcia als Mariachi Singer |
| Humberto Perez Mendoza als Mariachi Singer |
| Medford Brown als Meat Man |
| Jwaundace Candece als Agent (uncredited) |
| Earl Will Eubank als Army Enlisted (uncredited) |
| Jacob Keith Bristol als Army Enlisted (uncredited) |
| Kevin Petruski Jr. als Army Enlisted (uncredited) |
| Douglas Knieriem als Enlisted Military (uncredited) |
| Jeffrey Blanton als Army Enlisted (uncredited) |
 | Jock McKissic als Rico (uncredited) |
| Joey Renfroe als Army Enlisted (uncredited) |
| James Tilley als Army Enlisted (uncredited) |
| Christian Noël als Sergei's Assistant (uncredited) |
 | Andrew Tinpo Lee als Mr. Peacock (uncredited) |
| Bardia Zadeh als Microsoft Employee (uncredited) |
| Jay D. Kacho als Senior Civilian Analyst (uncredited) |
| Ben Falcone | Director |
| Steve Mallory | Writer |
| Rob Cowan | Producer |
| Ben Falcone | Producer |
| Melissa McCarthy | Producer |
| Jason Cloth | Executive Producer |
| Aaron L. Gilbert | Executive Producer |
| Fil Eisler | Original Music Composer |
| Barry Peterson | Director of Photography |
| Tia Nolan | Editor |
| Jeremy Woolsey | Art Direction |
| Missy Parker | Set Decoration |
| Melanie Ghisays | Costume Design |
| Allison Jones | Casting |
| Kris Redding | Casting |
| Deborah Simmrin | Unit Publicist |
| Hopper Stone | Still Photographer |
| Rob Cowan | Unit Production Manager |
| Richard Cowan | First Assistant Director |
| David Waters | Second Assistant Director |
| Celia Khong | Associate Producer |
| Walter Garcia | Stunt Coordinator |
| Luci Romberg | Stunt Coordinator |
| Mary H. Ellis | Sound Mixer |
| Troy A. Johnson | Boom Operator |
| Ruth Hasty | Post Production Supervisor |
| Tim LeBlanc | Sound Re-Recording Mixer |
| Cameron Frankley | Sound Re-Recording Mixer |
| Cameron Frankley | Sound Designer |
| Cameron Frankley | Sound Supervisor |
| Jon Michaels | Supervising Sound Editor |
| Jon Michaels | Supervising Dialogue Editor |
| Jon Michaels | Supervising ADR Editor |
| Angela Ang | Dialogue Editor |
| Dan Kenyon | Sound Effects Editor |
| Thomas J. O'Connell | ADR Mixer |
| Chris Navarro | ADR Mixer |
| Jason Oliver | ADR Mixer |
| Randy Singer | Foley Mixer |
| Catherine Harper | Foley Artist |
| Katherine Rose | Foley Artist |
| Kurt Kornemann | Key Grip |
| Kimberly Jones | Makeup Department Head |
| Sarah Graham | Key Makeup Artist |
| Pamela S. Westmore | Makeup Artist |
| Shunika Terry | Hair Department Head |
| Lisa Ann Wilson | Key Hair Stylist |
| Linda D. Flowers | Hairstylist |
| Jwaundace Candece | Stunts |
| Peter Epstein | Stunts |
| Meredith Richardson | Stunts |
| Katie Eischen | Stunts |
| Isaac Hughes | Stunts |
| Gary Peebles | Stunts |
| Kris Krosskove | "A" Camera Operator |
| Jeffrey N. Civa | First Assistant "A" Camera |
| Trey Twitty | Second Assistant "A" Camera |
| Casey Hotchkiss | "B" Camera Operator |
| Fred Thomas | First Assistant "B" Camera |
| Nick Cannon | Camera Loader |
| Jennifer Braddock | Camera Loader |
| Benjamin Farthing | Sound |
| Stuart Sperling | First Assistant Editor |
| Kristine McPherson | First Assistant Editor |
| Lorena Talpan | Visual Effects Editor |
| Richard Brener | Executive Producer |
| Brittany Hites | Assistant Art Director |
