 | Philip Seymour Hoffman als Caden Cotard |
 | Samantha Morton als Hazel |
 | Jennifer Jason Leigh als Maria |
 | Michelle Williams als Claire Keen |
 | Catherine Keener als Adele Lack |
 | Emily Watson als Tammy |
 | Tom Noonan als Sammy Barnathan |
 | Sadie Goldstein als Olive (4 years old) |
 | Hope Davis als Madeleine Gravis |
 | Dianne Wiest als Ellen Bascomb / Millicent Weems |
 | Stanley Krajewski als Actor as Caden |
 | Kristen Bush als Actress Playing Claire |
 | Alice Drummond als Actress Playing Frances |
 | Amy Wright als Burning House Realtor |
 | Deirdre O'Connell als Ellen's Mother |
 | Elizabeth Marvel als Warehouse Realtor |
 | Charles Techman als Like Clockwork Patient |
 | Tom Greer als Medic |
 | Josh Pais als Ophthalmologist |
 | Lynn Cohen als Caden's Mother |
 | Jerry Adler als Caden's Father |
 | Daisy Tahan als Ariel |
 | Frank Girardeau als Plumber |
 | Peter Friedman als Emergency Room Doctor |
 | Daniel London als Tom |
 | Robert Seay als David |
 | Stephen Adly Guirgis als Davis |
 | Joe Lisi als Maurice |
 | Michael Medeiros als Eric |
 | Christopher Evan Welch als Pastor |
 | William Ryall als Jimmy |
 | Rosemary Murphy als Frances |
 | John Rothman als Dentist |
 | Paul Sparks als Derek |
 | Tim Guinee als Needleman Actor |
 | Robin Weigert als Adult Olive |
 | Michael Higgins als Actor Playing Man with Nose Bleed |
 | Barbara Haas als Warehouse Actress |
| Greg McFadden als Actor Playing Needleman Actor |
 | Alvin Epstein als Man with Nose Bleed |
 | Gerald Emerick als Man in Line |
 | Chris McGinn als Lady at Caden's Mom's |
 | Dan Ziskie als Leg Tremor Doctor |
 | Portia als Therapy Patient Actress |
 | Nicholas Wyman als Soap Actor Doctor |
 | Amy Spanger als Soap Actress Nurse |
| Timothy Doyle als Michael |
| Cliff Carpenter als Old Man |
| Raymond Angelic Sr. als German Doctor |
 | Erica Fae als German Woman |
 | Mark Lotito als Minister |
| Laura Odeh als Toystore Clerk |
| Deanna Storey als Jazz Singer |
 | Frank Wood als Evaluative Services Doctor |
| Amanda R. Phillips als Emergency Room Nurse |
| Kat Peters als Ellen (10 years old) |
| Spike Jonze | Producer |
| Charlie Kaufman | Producer |
| Ray Angelic | Executive Producer |
| Frederick Elmes | Director of Photography |
| William Horberg | Executive Producer |
| Jon Brion | Original Music Composer |
| Anthony Bregman | Producer |
| Sidney Kimmel | Producer |
| Bruce Toll | Executive Producer |
| Robert Frazen | Editor |
| Philip Stockton | Supervising Sound Editor |
| Drew Jiritano | Special Effects Coordinator |
| Dror Gescheit | Sound Re-Recording Mixer |
| Melissa Toth | Costume Design |
| Drew Kunin | Sound Mixer |
| Reilly Steele | Sound Re-Recording Mixer |
| Jeanne McCarthy | Casting |
| Eugene Gearty | Sound Re-Recording Mixer |
| Adam Stockhausen | Art Direction |
| Eugene Gearty | Sound Designer |
| Mark Friedberg | Production Design |
| Lydia Marks | Set Decoration |
| Eugene Gearty | Supervising Sound Editor |
| Charlie Kaufman | Director |
| Charlie Kaufman | Screenplay |
| Mary Cybulski | Script Supervisor |
| Mark Goodermote | Boom Operator |
| Sandy Hamilton | Property Master |
| Frank Kern | Foley Supervisor |
| Roopesh Gujar | Visual Effects Producer |
| Jon Brion | Conductor |
| Jonathan Lumley | Gaffer |
| John Bair | Visual Effects Supervisor |
| Mark Pollard | Assistant Art Director |
| Judy Chin | Makeup Department Head |
| Kim Jennings | Storyboard Artist |
| Erica Kay | Production Supervisor |
| Mike Marino | Prosthetic Makeup Artist |
| Glenn Allen | Visual Effects Producer |
| Brett Miller | CG Supervisor |
| T. Patrick Johnson | Production Coordinator |
| Jamie Baker | Foley Editor |
| Eric J. Robertson | Visual Effects Supervisor |
| Leslie Woo | Casting Assistant |
| Angela Mirabella | Key Costumer |
| Joanne Bloom | Casting Assistant |
| Mark Hagerman | Production Coordinator |
| Philip Stockton | Dialogue Editor |
| Marko Costanzo | Foley Artist |
| Ruth Hernandez | ADR Editor |
| John Bair | Title Designer |
| Mary Gierczak | Costumer |
| Jerry DeCarlo | Hair Department Head |
| Branka Mrkic | Dialogue Editor |
| Brian Smyj | Stunt Coordinator |
| Naomi Donne | Makeup Designer |
| Richard Friedlander | Visual Effects Producer |
| Alec Styborski | Visual Effects Assistant Editor |
| Jon Brion | Orchestrator |
| Bonnie Greenberg | Music Supervisor |
| Amy Pickering | Wardrobe Supervisor |
| George A. Lara | Foley Mixer |
| Jesh Murthy | Visual Effects Supervisor |
| Mark Russell | Visual Effects Supervisor |
| Deborah Jensen | Assistant Art Director |
| Cara Borrelli | Key Costumer |
| Renuka Ballal | Visual Effects Producer |
| Paloma Añoveros | Visual Effects Producer |
| Steve Bartek | Orchestrator |
| Nicole Abellara Hallman | Casting Associate |
| Kim Jennings | Assistant Art Director |
| Chris Ann Pappas | Assistant Costume Designer |
| Kam Chan | Foley Editor |
| Parker Chehak | Visual Effects Coordinator |
| Lukasz Jogalla | Camera Operator |
| Mandy Lyons | Key Hair Stylist |
| Scott Frankel | Visual Effects Supervisor |
| Charlotte Fleck | Dialect Coach |
| Rori Bergman | Casting Associate |
| Beth Moran | Assistant Editor |
| Catherine Tate | Compositing Supervisor |
| Jim Schultz | Supervising Music Editor |
| Arlynn Abseck | Wardrobe Supervisor |
| Fred Rosenberg | Dialogue Editor |
| Jessica Levin | Post Production Supervisor |
| H.H. Cooper | First Assistant Director |
| Chantal Nong Vo | Executive Producer's Assistant |
