 | Jamie Dornan als Dr. Allan Pascal |
 | Sarah Gadon als Natalie Drax |
 | Aaron Paul als Peter Drax |
 | Molly Parker als Dalton |
 | Aiden Longworth als Louis Drax |
 | Oliver Platt als Dr. Perez |
 | Barbara Hershey als Violet Drax |
 | Julian Wadham als Dr. Janek |
 | Jane McGregor als Sophie |
 | Fiona Vroom als Receptionist |
 | Terry Chen als Elliott |
 | Anjali Jay als Macy |
 | Lina Roessler als Caitlin |
 | Luke Camilleri als Alex |
 | Alex Zahara als Eduardo Navarra |
 | Beckham Skodje als Louis (Age 2) |
 | Anthony Shudra als Milo |
 | Nels Lennarson als Morgue Technician |
 | Michael Adamthwaite als Doctor (C-Section) |
 | Iris Paluly als Psych Patient #1 |
 | David Lloydy als Psych Patient #2 |
| Justin Bowe als Jack |
 | Sarah-Jane Redmond als Helen |
 | Adam Abrams als X-Ray Doctor |
 | Goldie Hoffman als ER Nurse |
 | Randi Lynne als ER Nurse |
 | John Hainsworth als ER Patient |
 | Spencer Drever als Bully Kid (uncredited) |
| Dakota Guppy als Young Girl (uncredited) |
| Liz Jensen | Novel |
| Max Minghella | Screenplay |
| Alexandre Aja | Director |
| Patti Henderson | Script Supervisor |
| Cathy Darby | Assistant Costume Designer |
| Doane Gregory | Still Photographer |
| Peter Wilke | Steadicam Operator |
| Jeremy Nitsch | Assistant Property Master |
| Max Minghella | Producer |
| Gavin Coford | Boom Operator |
| Phil Pastuhov | Aerial Director of Photography |
| Randy Hutniak | Assistant Art Director |
| Jonathan Collard | Digital Intermediate |
| Maureen Webb | Casting |
| Baxter | Editor |
| David Tickell | Gaffer |
| Ian Seabrook | Underwater Director of Photography |
| Peter Zuccarini | Underwater Director of Photography |
| Martin Cantwell | Sound Effects Editor |
| Jamie Roden | Sound Re-Recording Mixer |
| Angela Barson | Visual Effects Supervisor |
| Teresa Ngan | Art Department Coordinator |
| Nigel Evans | Art Direction |
| James Sutton | 3D Artist |
| Mariah Crawley | Hairstylist |
| Julie McHaffie | Key Hair Stylist |
| Dave Righton | Assistant Property Master |
| Kate Marshall | Set Decoration |
| Alex Maclean | Title Designer |
| Jak Osmond | Special Effects Coordinator |
| Patrick Malone | Digital Intermediate |
| Laurence Love Greed | Music Editor |
| Sascha Fromeyer | Visual Effects Producer |
| Alexandre Aja | Producer |
| Tim Bricknell | Producer |
| Maxime Alexandre | Director of Photography |
| Vanessa Baker | ADR Voice Casting |
| Gareth Rhys Jones | Foley |
| Jesse Joslin | Construction Coordinator |
| Alex Martinez | First Assistant Camera |
| Mason Hnatiw | Boom Operator |
| Carla Hetland | Costume Design |
| Toby Langley | Visual Effects Coordinator |
| Tim Cavagin | Sound Re-Recording Mixer |
| Thom Kyle | First Assistant Editor |
| Shawn Williamson | Producer |
| Julie Alexandra Lepage | Set Costumer |
| Rob Farris | Digital Intermediate |
| Taylor Matheson | First Assistant Camera |
| James M. Jackson | Best Boy Electric |
| Michael O'Farrell | Supervising Sound Editor |
| Patrick Watson | Music |
| Rachel O'Toole | Production Design |
| Dylan Rogers | Casting Assistant |
| Robin Hinch | VFX Editor |
| Julien Pirrie | Foley |
| Mathias Schuster | Foley Editor |
| Connie Parker | Makeup Department Head |
| Henry Badgett | Visual Effects Supervisor |
| Tyler Smith | Property Master |
| Thialy Sow | First Assistant Editor |
| Stephen Maier | Second Unit Director of Photography |
