 | Peter Weller als Buckaroo Banzai |
 | John Lithgow als Lord John Whorfin |
 | Ellen Barkin als Penny Priddy |
 | Jeff Goldblum als New Jersey |
 | Christopher Lloyd als John Bigboote |
 | Lewis Smith als Perfect Tommy |
 | Rosalind Cash als John Emdall |
 | Robert Ito als Professor Hikita |
 | Pepe Serna als Reno Nevada |
 | Ronald Lacey als President Widmark |
 | Matt Clark als Secretary of Defense |
 | Clancy Brown als Rawhide |
 | William Traylor als General Catburd |
 | Carl Lumbly als John Parker |
 | Vincent Schiavelli als John O'Connor |
 | Dan Hedaya als John Gomez |
 | Mariclare Costello als Senator Cunningham |
 | Bill Henderson als Casper Lindley |
 | Damon Hines als Scooter Lindley |
 | Billy Vera als Pinky Carruthers |
 | Laura Harrington als Mrs. Johnson |
 | Michael Santoro als Billy Travers |
 | Jonathan Banks als Lizardo Hospital Guard |
 | Robert Gray als Radar Blazer |
| Gary Bisig als Radar Blazer |
 | Kent Perkins als Mission Control |
 | John Ashton als Highway Patrolman |
 | Ken Magee als Duck Hunter Burt |
 | James Keane als Duck Hunter Bubba |
 | Yakov Smirnoff als National Security Advisor |
 | Leonard Gaines als Artie Duncan |
| Francine Lembi als TV Anchorwoman |
 | John Walter Davis als Star Surgeon |
 | Read Morgan als Exhibitor |
 | James Rosin als John Yaya |
| W.D. Richter | Director |
| Neil Canton | Producer |
| Michael Boddicker | Original Music Composer |
| Earl Mac Rauch | Screenplay |
| George Bowers | Editor |
| Fred J. Koenekamp | Director of Photography |
| Jane Schwartz Jaffe | First Assistant Editor |
| Dennis E. Jones | Unit Production Manager |
| Gary Daigler | First Assistant Director |
| Katterli Frauenfelder | Second Assistant Director |
| Michael G. Nathanson | Executive In Charge Of Production |
| Terry Liebling | Casting |
| Aggie Guerard Rodgers | Costume Design |
| Bones Howe | Music Supervisor |
| Bones Howe | Sound Designer |
| Michael L. Fink | Visual Effects Supervisor |
| Rick Carter | Art Direction |
| Stephen Dane | Art Direction |
| Linda DeScenna | Set Decoration |
| Virginia Randolph-Weaver | Set Designer |
| Tom Cranham | Production Illustrator |
| Tom Southwell | Production Illustrator |
| Sherman Labby | Production Illustrator |
| Erik L. Nelson | Property Master |
| David P. Newell | Assistant Property Master |
| Edward Morey III | Camera Operator |
| Tony Rivetti Sr. | First Assistant Camera |
| Billy Clevenger | Second Assistant Camera |
| Bruce McBroom | Still Photographer |
| H. Bud Otto | Script Supervisor |
| Michael Evje | Production Sound Mixer |
| James M. McCann | Boom Operator |
| Sal Orefice | Gaffer |
| John Murray | Key Grip |
| Henry Millar | Special Effects |
| David Blitstein | Special Effects |
| Eddie Marks | Costume Supervisor |
| Linda Henrikson | Costumer |
| Bari Dreiband-Burman | Makeup Supervisor |
| Stephen Robinette | Hairstylist |
| Cheryl Bloch | Assistant Editor |
| Gordon Ecker | Supervising Sound Editor |
| Anthony Milch | Supervising Sound Editor |
| Doreen A. Dixon | ADR Editor |
| Brian Ralph | Negative Cutter |
| Kenneth Karman | Music Editor |
| John Roesch | Foley |
| Joan Rowe | Foley |
| John T. Reitz | Sound Re-Recording Mixer |
| David E. Campbell | Sound Re-Recording Mixer |
| Gregg Rudloff | Sound Re-Recording Mixer |
| Judi Rosner | Production Coordinator |
| M. James Arnett | Stunt Coordinator |
| George Stokes | Construction Coordinator |
| Michael Neale | Location Manager |
| Gary Hellerstein | Transportation Coordinator |
| Rocco Gioffre | Matte Painter |
| Wayne Fitzgerald | Title Designer |
| Sidney Beckerman | Executive Producer |
| Dennis E. Jones | Associate Producer |
| W.D. Richter | Producer |
| Richard Marks | Editor |
| J. Michael Riva | Production Design |
| Mic Rodgers | Stunts |
| Michael Runyard | Stunts |
| Tommy J. Huff | Stunts |
