 | Kumail Nanjiani als Kumail Nanjiani |
 | Zoe Kazan als Emily Gardner |
 | Holly Hunter als Beth Gardner |
 | Ray Romano als Terry Gardner |
 | Anupam Kher als Azmat Nanjiani |
 | Zenobia Shroff als Sharmeen Nanjiani |
 | Adeel Akhtar als Naveed Nanjiani |
 | Bo Burnham als CJ |
 | Aidy Bryant als Mary |
 | Kurt Braunohler als Chris |
 | Vella Lovell als Khadija |
 | Myra Lucretia Taylor als Nurse Judy |
 | Jeremy Shamos als Bob Dalavan |
 | David Alan Grier als Andy Dodd |
 | Ed Herbstman als Sam Highsmith |
 | Shenaz Treasury als Fatima Nanjiani |
 | Rebecca Naomi Jones als Jesse |
 | Kuhoo Verma als Zubeida |
 | Mitra Jouhari als Yazmin |
 | Celeste Arias als Denise |
 | Shana Solomon als Nurse Bette |
 | Jeff Blumenkrantz als Dr. Wright |
 | Linda Emond als Dr. Cunningham |
 | Holly Chou als Dr. Whelan |
 | Andrew Pang als Dr. Spellman |
 | Alison Cimmet als Dr. Platt |
 | Lawrence Ballard als Dr. Lewin |
 | Shunori Ramanathan als Sumera |
 | Spencer House als Racist Heckler |
 | Susham Bedi als Tina (Khadija's Mother) |
 | Rahul Bedi als Farhan (Khadija's Father) |
 | Matthew Cardarople als Fast Food Cashier |
 | Myra Turley als Waiting Room Person 1 |
 | William Stephenson als Waiting Room Person 2 |
 | Marilyn Torres als Waiting Room Person 3 |
 | Kerry Flanagan als Waiting Room Person 4 |
 | Jack O'Connell als Waiting Room Person 5 |
 | Charles Gould als Waiting Room Person 6 |
 | Isabel Shill als Party Goer 1 |
 | Lauren Patten als Party Goer 2 |
 | Keilly McQuail als Party Goer 3 |
 | Zach Cherry als Party Goer 4 |
 | Jack Corrigan als Restaurant Boy (uncredited) |
 | Sophia Muller als Chrissy (uncredited) |
| Michael Showalter | Director |
| Judd Apatow | Producer |
| Barry Mendel | Producer |
| Cliff Alphonse | Grip |
| Jeremy Kipp Walker | Executive Producer |
| Brandon Tonner-Connolly | Production Design |
| Robert Nassau | Editor |
| Brian Burgoyne | Director of Photography |
| Michael Andrews | Original Music Composer |
| Gayle Keller | Casting |
| Joe Rudge | Music Supervisor |
| Amanda Glaze | Co-Producer |
| Glen Basner | Executive Producer |
| Ben Browning | Executive Producer |
| Kumail Nanjiani | Executive Producer |
| Emily V. Gordon | Executive Producer |
| Jeremy Kipp Walker | Unit Production Manager |
| Nicholas Bell | First Assistant Director |
| Adam J. Bernard | Second Assistant Director |
| Jeremy Sample | Stunt Coordinator |
| Annie Tan | Production Supervisor |
| Mariana Hellmund | Script Supervisor |
| Ari Issler | Camera Operator |
| Andrew Juhl | First Assistant Camera |
| Yousheng Tang | Steadicam Operator |
| Alec Jarnagin | Steadicam Operator |
| Nicole Rivelli | Still Photographer |
| Frank Larson | Camera Operator |
| Pierrot Colonna | Camera Operator |
| Fillip Penson | First Assistant Camera |
| Htat Htut | First Assistant Camera |
| Brent Poleski | Key Grip |
| Larhn Laurens Davitt | Dolly Grip |
| Nuno Oliveira | Grip |
| Parissh McClean | Grip |
| Anthony F. Gamiello | Grip |
| Sally Foster | Grip |
| Elizabeth Rodrick | Set Decoration |
| Jack Mortellaro Jr. | Leadman |
| Bill C. Bishop | Leadman |
| Anthony Taratunio | Set Dresser |
| Maeve Kelly | Assistant Costume Designer |
| Christina Nickas | Wardrobe Supervisor |
| Megan Sanders | Wardrobe Supervisor |
| Lauren Colbert | Costume Coordinator |
| Jason Velez | Gaffer |
| Francesco Pinna | Best Boy Electric |
| Andy Eklund | Art Direction |
| Shane Aitchison | Art Department Coordinator |
| Richard Hebrank | Construction Coordinator |
| Anthony S. Calypso | Assistant Property Master |
| Jeff Brink | Special Effects Coordinator |
| Leo Won | Makeup Department Head |
| Kirsten Sylvester | Key Makeup Artist |
| Raquel Vivve | Makeup Artist |
| Cynthia Chou | Production Coordinator |
| Nicki Slack | Assistant Production Coordinator |
| Jocelyn Magsumbol | Production Office Assistant |
| Roberto González Arévalo | Production Office Assistant |
| Jillian Stricker | Location Manager |
| Jerry 'Niru' Cox | Boom Operator |
| Paul Reed | Utility Sound |
| Junior Cyrus Baron | Utility Sound |
| Tonia Ciccone | Hair Department Head |
| Toni Roman-Grimm | Key Hair Stylist |
| Josh Gericke | Hairstylist |
| Bert Reo Anderson | Hairstylist |
| Johnny Holland | Production Accountant |
| Brad Gage | Actor's Assistant |
| Adrienne Enderle | Set Production Assistant |
| Matthew McCoubry | Set Production Assistant |
| Matt Merksamer | Set Production Assistant |
| Anthony Pennachio | Set Production Assistant |
| Jon Santo | Set Production Assistant |
| Alex Lilja | Set Production Assistant |
| Alex Spear | Set Production Assistant |
| Jasmine Brotzman | Set Production Assistant |
| Liz Wagner | Set Production Assistant |
| Robert Maasin | Set Production Assistant |
| Yadeed Mellman | Set Production Assistant |
| Ava Myint | Set Production Intern |
| Lauren Meckleberg | Set Production Intern |
| Isaac Gotterer | Set Production Intern |
| Ella Gibney | Set Production Intern |
| Allison Kirschner | Casting Associate |
| Nicole P. Hearon | Casting Associate |
| Aaron Schoonover | Casting Associate |
| George Holtzer | Transportation Captain |
| Peter Link | Driver |
| Bob Papini JR | Driver |
| Damon Tragni | Driver |
| PJ Ford | Driver |
| Ryan Murphy | Driver |
| Ed Elliot | Driver |
| Mike Devereaux | Driver |
| Mike Mcelroy | Driver |
| Mike Murphy | Driver |
| Michael Jackman | Post Production Supervisor |
| Luis Cuevas | Assistant Editor |
| Leah Tuscano | Assistant Editor |
| Tom Paul | Supervising Sound Editor |
| Bobby Mackston | Sound Editor |
| Dan Edelstein | ADR Editor |
| Sean Garnhart | Sound Effects Editor |
| Pam DeMetruis-Thomas | Foley Editor |
| Tom Paul | Sound Re-Recording Mixer |
| Mark Linden | Sound Re-Recording Mixer |
| Dann Fink | ADR Voice Casting |
| Bruce Winant | ADR Voice Casting |
| Azniv Korkejian | Music Editor |
| Lucien Harriot | VFX Supervisor |
| Fangge Chen | Digital Compositors |
| Constance Conrad | Digital Compositors |
| Saffia Rahimtoola | Digital Compositors |
| Melissa Kivell | VFX Production Coordinator |
| Adam Kersh | Publicist |
| Neal Jones | Visual Effects |
| Aaron Becker | Title Designer |
| Bill Orrico | Dialogue Editor |
| Lauren J. Brown | Property Master |
| William Smith | Set Dresser |
| Charles R. Hunt | Production Sound Mixer |
| Zach Wolf | Assistant Editor |
| Michael Elliott | Transportation Co-Captain |
| Joe Schultz | Driver |
| Kumail Nanjiani | Screenplay |
| Emily V. Gordon | Screenplay |
| Sarah Mae Burton | Costume Designer |
| Tara A. Paul | Sound Re-Recording Mixer |
