 | Aaron Eckhart als Dr. Josh Keyes |
 | Hilary Swank als Maj. Rebecca Childs |
 | Delroy Lindo als Dr. Ed 'Braz' Brazzleton |
 | Stanley Tucci als Dr. Conrad Zimsky |
 | Tchéky Karyo als Serge |
 | DJ Qualls als Theodore Donald 'Rat' Finch |
 | Richard Jenkins als Gen. Thomas Purcell |
 | Bruce Greenwood als Cmdr. Robert Iverson |
 | Christopher Shyer als Dave Perry |
 | Ray Galletti als Paul |
 | Eileen Pedde als Lynne |
 | Rekha Sharma als Danni |
 | Tom Scholte als Acker |
 | Glenn Morshower als FBI Agent |
 | Anthony Harrison als FBI Agent |
 | Alfre Woodard als Stickley |
 | Fred Keating als Court-Martial Presiding Officer |
 | Bart Anderson als Dad |
 | Nicole Leroux als Mom |
 | Justin Callan als Little Boy |
 | Chris Humphreys als GBTV Reporter - Trafalgar Square |
 | Dion Johnstone als Flight Engineer Timmins |
 | Fred Ewanuick als Endeavor Flight Engineer |
 | Hrothgar Mathews als Chief Engineer Mission Control |
| Ming-Tzong Hong als Scientist |
 | Jennifer Spence als Zimsky's Assistant |
 | Michael St. John Smith als Pentagon General |
 | John Shaw als FBI Agent - Rat's Apartment |
 | Nickolas Baric als Security Policeman - Tribunal |
 | Rosa Di Brigida als Rome Café Patron |
| Roberto Roberto als Rome Café Patron |
 | Ermanno De Biagi als Rome Café Patron |
| Marcello Laurentis als Rome Café Patron |
 | Matt Winston als Luke Barry |
 | Claire Riley als News Anchor |
| Marke Driesschen als News Anchor |
 | Laurie Murdoch als Project Destiny Engineer |
| Costa Spanos als Project Destiny Engineer |
| Monique Martel als Paris Café Lady |
 | Lenie Scoffié als Paris Café Lady |
 | Nathaniel DeVeaux als U.S.S. Constellation Captain |
| Robert Manitopyes als U.S.S. Constellation Screen Ops |
| Alejandro Abellan als U.S.S. Soldier (uncredited) |
| Benjamin Barton als Scientist / Extra (uncredited) |
| Angelica Hayden als Coffeehouse Patron (uncredited) |
| Robert Paul Lewis als Beach-goer (uncredited) |
 | Alec Medlock als (voice) (uncredited) |
 | Alonso Oyarzun als Security Policeman (uncredited) |
| Priscilla Poland als Scientist (uncredited) |
| Shawn Green als Himself |
| Greg Bennett als Technician - Virgil Base |
| Jeffrey Gold als Engineer (uncredited) |
 | Rick Kain als Chief Petty Officer (uncredited) |
 | Pamela Martin als News Anchor (uncredited) |
| John Rogers | Writer |
| Cooper Layne | Writer |
| Daniel J. Lester | Costume Design |
| David Foster | Producer |
| John Lindley | Director of Photography |
| Cooper Layne | Producer |
| Terry Rawlings | Editor |
| Jon Amiel | Director |
| Christopher Young | Original Music Composer |
| Sean Bailey | Producer |
| Philip Harrison | Production Design |
| Deborah Aquila | Casting |
| Tricia Wood | Casting |
| David B. Householter | Co-Producer |
| Andrea Alunni | Location Manager |
| Hans Schmidt | Scenic Artist |
| Jack Gauvreau | Sculptor |
| Pierre 'Bill' Rivard | Special Effects Coordinator |
| Jeff Goldman | CG Supervisor |
| Gene Senior | Visual Effects Producer |
| Roberto De Angelis | Steadicam Operator |
| Marc Rogers | Lighting Technician |
| Michael Mooney | Costume Supervisor |
| Blue Angus | Transportation Coordinator |
| Jan Kobylka | Construction Coordinator |
| Ken Fischer | Sound Effects Editor |
| Michael Payne | Sound Effects Editor |
| Cosmas Paul Bolger Jr. | Visual Effects Producer |
| Ian Hunter | Visual Effects Supervisor |
| Stephen Coutu | Scenic Artist |
| Daniel Pokorny | Sculptor |
| Rusty Ippolito | CGI Supervisor |
| Simon Baker | Steadicam Operator |
| Ralph Flores Jr. | Gaffer |
| Thomas Milano | Music Editor |
| Bob Bottieri | Scenic Artist |
| Murray Gilmour | Set Designer |
| Michelle Eisenreich | Visual Effects Producer |
| Sara Henschke | Visual Effects Producer |
| Ken Zorniak | Visual Effects Producer |
| Jamie Dixon | Visual Effects Supervisor |
| Bryan Hirota | Visual Effects Supervisor |
| Robert Q. Mathews | Costume Supervisor |
| Denyse Nelson | Leadman |
| Mario Tomas-Niedworok | Scenic Artist |
| Daniel Scarcello | Sculptor |
| Lubor Cencak | Scenic Artist |
| Tom Blacklock | Special Effects Coordinator |
| Michael Shand | CG Supervisor |
| Desi Ortiz | Visual Effects Editor |
| Lin MacDonald | Set Decoration |
| Franklin Leibel | Scenic Artist |
| Anthony Milch | Supervising Sound Editor |
| Chow Emrich | CG Supervisor |
| Les G. Jones | Visual Effects Producer |
| Tanya Noel Hill | Music Editor |
| Nancy Anna Brown | Set Designer |
| Roderick Thomas Quin | Sculptor |
| Harry Cohen | Sound Designer |
| Jay Nierenberg | Sound Effects Editor |
| Andy Koyama | Sound Re-Recording Mixer |
| Denise Davis | Visual Effects Producer |
| Val Drake | Sculptor |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Victoria Alonso | Visual Effects Producer |
| Roberto Di Coste | Transportation Coordinator |
| Chris Jenkins | Sound Re-Recording Mixer |
| Andy Lesniak | CGI Supervisor |
| Lynne Carrow | Casting |
| Carole Mondello | Art Department Coordinator |
| Doug Currie | Scenic Artist |
| Jeremy Braben | Helicopter Camera |
| Leonardo Beltrame | Gaffer |
| Cate Praggastis | Casting |
| Shaila Rubin | Casting |
| Sandi Tanaka | Art Direction |
| Peter Sysoev | Scenic Artist |
| Tim Walston | Sound Designer |
| Tony Clark | Visual Effects Supervisor |
| Gregory L. McMurry | Visual Effects Supervisor |
| Michael Menapace | Transportation Coordinator |
| Gene Warren Jr. | Visual Effects Supervisor |
| Alessandra Sangermano | Video Assist Operator |
| Ray Potter | Lighting Technician |
| Margo Baxley | Costume Supervisor |
| Ian Thompson | Picture Car Coordinator |
| Angelina P. Cameron | Hairstylist |
| Toby Lindala | Makeup Artist |
| Ellie Winslow | Makeup Artist |
| Martina Javorova | Art Department Coordinator |
| Stephen P. Robinson | Sound Effects Editor |
| Cosmas Paul Bolger Jr. | Visual Effects Supervisor |
| Tim Grover | Visual Effects Editor |
| Scott J. Ateah | Stunt Coordinator |
| Rob McEwan | Still Photographer |
| Tony Rush | Video Assist Operator |
| Dave Emmonds | Greensman |
| Dusty Kelly | Scenic Artist |
| John Leveque | Supervising Sound Editor |
| Steve Mann | Sound Effects Editor |
| Jay Stroburg | Rigging Gaffer |
| Vladimir Lushnikov | Sculptor |
| David Esparza | Sound Effects Editor |
| Gary D'Amico | Special Effects Coordinator |
| Leslie Huntley | Visual Effects Producer |
| Henry Cline | Camera Operator |
| Heather Page | Camera Operator |
| Candide Franklyn | Steadicam Operator |
| Bill Baxter | Rigging Gaffer |
| David R. Anderson | Transportation Coordinator |
| Stella D'Onofrio | Script Supervisor |
| Ari Flaisher | Location Manager |
| Lee Anne Muldoon | Unit Publicist |
| Tim Porter | Location Manager |
| Brigitte Lévesque | Location Manager |
| Maida N. Morgan | Location Manager |
| Christine Wilson | Script Supervisor |
| Janice Frome | Location Manager |
| Isabelle Gautier | Location Manager |
| Ellen Lent | Location Manager |
| Mary Jo Manwill-Conder | Script Supervisor |
| Sue Field | Script Supervisor |
| Scott Gordon | Visual Effects Supervisor |
| Charles O'Shea | Boom Operator |
| Sanna Seppanen | Key Hair Stylist |
| Andrew Neskoromny | Supervising Art Director |
| Susan Taylor Brouse | Local Casting |
| Jim Brebner | First Assistant Director |
| Bruce McCleery | Chief Lighting Technician |
| Zack Davis | ADR Editor |
| Stan Edmonds | Key Makeup Artist |
| Oliver Ward | Camera Technician |
| Lynn Basas | 3D Supervisor |
| Michael Bolan | Machinist |
| Sharon Thompson | Art Department Assistant |
| Ken Hovgaard | Location Scout |
| Herach Arzounian | Set Medic |
| Shawn Wallbridge | Systems Administrators & Support |
| Mike Crestejo | Stunts |
| Jenni Gullett | Assistant Costume Designer |
| Kathryn Moll | Driver |
| Carl D. Ware | Sound Engineer |
| Corey Bastiaans | Visual Effects |
| Matthew Lane | Loader |
| Tim Crosbie | Digital Effects Supervisor |
| Robert Milicevic | Security |
| Jennifer Munoz | Casting Associate |
| Lori Berlanga | Production Office Coordinator |
| Ali Macrae | Set Decoration Buyer |
| Bob Bedard | Chef |
| Thad Beier | Technical Supervisor |
| Don Dykens | Transportation Captain |
| Garry Elmendorf | Special Effects Supervisor |
| Andy Potvin | Dolby Consultant |
| Geoffrey James Dixon | Electrician |
| Keith Alexander | Production Coordinator |
| Dick Gardner | Assistant Art Director |
| Tim Grover | Post Production Supervisor |
| Timothy Scott Ralston | Projection |
| Vito Colazzo | Unit Production Manager |
| Michael Chenery | Researcher |
| Pete Anthony | Orchestrator |
| Darren Brisker | Sound Mixer |
| Koenraad Beugelink | Utility Stunts |
| Jean-Pierre Avice | Production Supervisor |
| Richard E. Yawn | Sound Editor |
| Jason Booth | Digital Compositors |
| Darek Gogol | Production Illustrator |
| Tim Scannell | First Assistant Camera |
| Rick Harasyn | Transportation Co-Captain |
| Maryjane Layani | Production Accountant |
| Jeff Khachadoorian | Carpenter |
| Kenneth Kantymir | Stand In |
| Darren Wall | Lighting Supervisor |
| Paolo Merosi | Set Production Assistant |
| Jim Passon | Color Timer |
| Eli Golub | Rigging Grip |
| Leigh-Alexandra Jacob | Painter |
| Gary B. Krakoff Jr. | Propmaker |
| Madhava Reddy | I/O Supervisor |
| Karl Rumpf | Visual Effects Coordinator |
| Cary Cooper | Set Dresser |
| Vicki Galloway Weimer | Digital Effects Producer |
| Daniel Deschamps | Key Grip |
| Richard Ellison | Grip |
| Linda Leduc | Costume Coordinator |
| Kurt E. Soderling | Aerial Director of Photography |
| Glen Hawkins | Dolly Grip |
| Chris Dutton | Assistant Property Master |
| Claudio Manzi | Wardrobe Supervisor |
| Ivana Primorac | Hair Supervisor |
| Anande Maré-Cross | Casting Assistant |
| Bernard Weiser | Supervising Dialogue Editor |
| Kimberly Lowe Voigt | Supervising ADR Editor |
| Maxx Okazaki | 3D Modeller |
| Silver Butler | Third Assistant Director |
| Chris Carpenter | Additional Sound Re-Recording Mixer |
| Andrew M. Robinson | Second Assistant Director |
| Richard O. Helmer | Pyrotechnician |
| Peter Commins | 3D Artist |
| James Fantin | Assistant Production Coordinator |
| Bradley Clouse | Assistant Sound Editor |
| Scott Curtis | Foley Editor |
| Edward Quirk | 3D Animator |
| Matthew Adams | Roto Supervisor |
| Barbara Harris | ADR Voice Casting |
| Ben Skorstad | Pilot |
| George Doering | Musician |
| William Gammon | 2D Artist |
| Mark Gordon | Dialogue Editor |
| Vic Radulich | Dialogue Editor |
| Francesco Postiglione | Property Master |
| Bill Meadows | Sound Recordist |
| Susan Kurtz | Dialogue Editor |
| Dean Eilertson | Property Master |
| James Bitonti | Second Second Assistant Director |
| Mike Dubé | Assistant Chief Lighting Technician |
| Andrew Buziak | Payroll Accountant |
| Brodie Davison | Costume Set Supervisor |
| A.J. Calomay | Visual Effects Production Assistant |
| Robert K. Feldmann | First Company Grip |
| Krassimir Ivanov | Casting Assistant |
| Giovanni Dulay | Production Assistant |
| David Fernandez | Costumer |
| Mario Lorenzo | Sound Supervisor |
| Erin Hicke | Visual Effects Production Manager |
| Garry Brook | Second Company Grip |
| Constance Bracewell | Digital Supervisor |
| Dan Clark | Special Effects Assistant |
| Greg Bellavance | Special Effects Technician |
| Martin November | Visual Effects Assistant Editor |
| Jamie Edgell | Stunt Driver |
| Steven J. Scott | Digital Intermediate Colorist |
| Hilda Saffari | Digital Intermediate Producer |
| Scott Steyns | Playback Coordinator |
| Hamish Purdy | Assistant Decorator |
| Barry Kootchin | Paint Coordinator |
| Lisa Ratke | Extras Casting |
| Yun | Extras Casting Assistant |
| Elizabeth Cier | Extras Casting Coordinator |
| Eric Berger | Technical Advisor |
| Wayne Baker | Assistant Camera |
| Sonu Mishra | Costume Assistant |
| Jerry Bingham | Storyboard Artist |
| David M. Rodriguez | First Assistant Accountant |
| Gilbert Jamault | Generator Operator |
| Erik Henry | Additional Visual Effects |
| Kristina Santoro | Location Assistant |
| Margo MacPherson | Production Secretary |
| Loree Cameron | Graphic Designer |
| Karen Schell | Sound Assistant |
| Ginger Joyce | Accountant |
| Gary Abrahamian | CG Artist |
| Gregory Astop | Assistant Location Manager |
| Scott Beverly | Effects Supervisor |
| Christopher Woods | Second Unit Director |
| Julie Bygrave | Assistant Accountant |
| Joey Box | Stunt Double |
| Victor Abbene | Chief Lighting Technician |
| Marcus Trahan | Matte Painter |
| Rick Canelli | ADR Recordist |
| Robin Harlan | Foley Artist |
| Randy Singer | Foley Mixer |
| Eric Vincent Cruse | Best Boy Grip |
| Tony Magaletta | Second Assistant Camera |
| Richard Long | Assistant Editor |
| Donald Fly | General Manager |
| Tone Rorvik | Assistant Makeup Artist |
| Bob Baron | ADR Mixer |
| Jason Eskeland | Assistant Property Master |
| Gary A. Krakoff | Construction Coordinator |
| G. Scott Stewart | Construction Buyer |
| Ron Clifford | Construction Foreman |
| Marco A. Campos | Construction Foreman |
| John Alvarez | Draughtsman |
| Michael Corrado | Draughtsman |
| Andrew Li | Draughtsman |
| Ginny Sakamoto | Draughtsman |
| Colin Matthews | Property Master |
| Douglas Foreman | Property Master |
| Lee Campbell | Set Decorating Coordinator |
| Tim Dagley | Set Dresser |
| Jeremy Hanen | Set Dresser |
| Steve Miller | Set Dresser |
| Guy Roland | Set Dresser |
| Scott R. Lee | Set Dresser |
| M. Chuck Robinson | Set Dresser |
| Richard D. Wright | Set Dresser |
| Wayne Coe | Storyboard Artist |
| Peter Ramsey | Storyboard Artist |
| P.K. MacCarthy | Storyboard Artist |
| Fireball Tim Lawrence | Storyboard Artist |
| Jenny Amberson | Assistant Hairstylist |
| Jeannie Chow | Assistant Hairstylist |
| Roberta Petrini | Hairstylist |
| Jessica Rain | Hairstylist |
| Deborah K. Larsen | Key Makeup Artist |
| Stefania Petrini | Makeup & Hair Assistant |
| Michelle Lemieux | Makeup Artist |
| Ivana Primorac | Makeup Supervisor |
| Christopher Prampin | Assistant Chief Lighting Technician |
| Lee Walters | Chief Lighting Technician |
| Michel Gonkel | Chief Lighting Technician |
| Burton 'Joe' Kuchera | Chief Lighting Technician |
| Christopher Woods | Second Unit Director of Photography |
| Steve Machan | Dolly Grip |
| Todd Fairbairn | Electrician |
| Vince Laxton | Electrician |
| Guy R. LeBlanc | Electrician |
| Robert Stone | Electrician |
| Christopher Reusing | Electrician |
| Benoît Lamarche | First Company Grip |
| Kevin Fair | Second Unit First Assistant Director |
| Paul Turner | Second Unit First Assistant Director |
| Jeff Mosuk | Second Assistant Director |
| Andy Koyama | Additional Sound Re-Recording Mixer |
| Tammy Fearing | ADR Editor |
| Eliza Pollack Zebert | ADR Editor |
| Thomas J. O'Connell | ADR Mixer |
| Eric Thompson | ADR Mixer |
| Chris Navarro | ADR Recordist |
| Philip Rogers | ADR Recordist |
| Ronnie Morgan | Assistant Sound Editor |
| Mario A. Vitale | Assistant Sound Editor |
| Ann L. Thornberg | Assistant Sound Editor |
| Sarah Monat | Foley Artist |
| Dan Olivo | Foley Artist |
| Christopher Flick | Foley Editor |
| Scott G.G. Haller | Foley Editor |
| Tony Dawe | Sound Mixer |
| Simon Poudrette | Sound Mixer |
| Fabio Felici | Sound Mixer |
| Kyle Goodsell | 2D Artist |
| Zoe Lamaera | 2D Artist |
| Jason Madigan | 2D Artist |
| Adam Paschke | 2D Artist |
| Evan Shipard | 2D Artist |
| Jason Valler | 2D Artist |
| Tim Kings-Lynne | 3D Artist |
| Dylan Neill | 3D Artist |
| Jeremy Pronk | 3D Artist |
| Tylney Taylor | 3D Artist |
| Thomas Dadras | Animation |
| Justin Jones | Animation |
| Robert Lurye | Animation |
| Rebecca Marie | Animation |
| Aliza Corson Chameides | Animation |
| Wes Takahashi | Animation |
| Kino Scialabba | Visual Effects Art Director |
| Tim Brandt | CG Artist |
| John Cassella | CG Artist |
| Kent Estep | CG Artist |
| Amy Garback | CG Artist |
| Rod Ibanez | CG Artist |
| Richard Liukis | CG Artist |
| Ira Shain | CG Artist |
| Kyle Yamamoto | CG Artist |
| Chris Byron | Compositing Artist |
| Shane Davidson | Compositing Artist |
| Sean Konrad | Compositing Artist |
| Christine Albers | Compositing Artist |
| Patrick Kavanaugh | Compositor |
| Paul Kulikowski | Compositor |
| John E. Sasaki | Compositor |
| Melissa Best | Compositor |
| Chris Crowell | Digital Compositor |
| Richard Kratt | Digital Compositor |
| Colin Liggett | Digital Compositor |
| Dan Kaufman | Digital Effects Supervisor |
| Christopher Warren | VFX Director of Photography |
| Ron Honn | Matte Painter |
| Don Baker | VFX Director of Photography |
| Kate St-Pierre | Visual Effects Coordinator |
| Randal Shore | Visual Effects Coordinator |
| Ian Cope | Visual Effects Producer |
| Kathy Hubble | Stunts |
| Lisa Dunne | Stunts |
| Crystal Dalman | Stunts |
| Leanne Buchanan | Stunts |
| Joni Avery | Stunts |
| John Ulmer | Stunts |
| Mark Stefanich | Stunts |
| Darryl Scheelar | Stunts |
| Raymond Sammel | Stunts |
| Ronald Robinson | Stunts |
| Gary Robert | Stunts |
| Milan Alavanja | Stunts |
| Steven McMichael | Stunts |
| Ryan Ennis | Stunts |
| Garvin Cross | Stunts |
| Curt Bonn | Stunts |
| Doug Chapman | Stunt Double |
| Rick Avery | Stunt Coordinator |
| Doug Coleman | Stunt Double |
| Crystal Dalman | Stunt Double |
| Owen Walstrom | Stunts |
| Tom Taylor | VFX Artist |
