 | Johnny Knoxville als Luke Duke |
 | Seann William Scott als Bo Duke |
 | Jessica Simpson als Daisy Duke |
 | Willie Nelson als Uncle Jesse Duke |
 | Burt Reynolds als Jefferson Davis 'Boss' Hogg |
 | M.C. Gainey als Sheriff Rosco P. Coltrane |
 | James Roday Rodriguez als Billy Prickett |
 | David Koechner als Cooter Davenport |
 | Michael Weston als Deputy Enos Strate |
 | Nikki Griffin als Katie Johnson |
 | Alice Greczyn als Laurie Pullman |
 | Joe Don Baker als Governor Jim Applewhite |
 | Lynda Carter als Pauline |
 | Kevin Heffernan als Sheev |
 | Steve Lemme als Jimmy |
 | Michael Roof als Dil Driscoll |
 | Jack Polick als Deputy Cletus Hogg |
 | Jacqui Maxwell als Annette |
 | Charlie Finn als Royce |
| Therial 'Houseman' DeClouet als Judge Locke Randolph |
 | Jim Cody Williams als Security Guard Chip |
 | Wayne Douglas Morgan als Prisoner |
| Junior Brown als The Balladeer (voice) |
 | Tobi Gadison |
 | Andrew Prine als Angry Man |
 | David Leitch als Puncher |
 | Christina Dare als Sorority Girl |
 | Jay Chandrasekhar als Campus Cop #1 |
 | Erik Stolhanske als Campus Cop #2 |
| A.J. Foyt IV als Race Car Driver #1 |
| Dolan Wilson als Local #2 |
 | Heather Hemmens als Girl #1 |
| Mitch Braswell als Out of Towner #1 |
 | Rusty Tennant als Local #1 |
| Bill Gerber | Producer |
| Eric McLeod | Executive Producer |
| Lawrence Sher | Director of Photography |
| Dana Goldberg | Executive Producer |
| Jay Chandrasekhar | Editor |
| Jon Gary Steele | Production Design |
| Lee Haxall | Editor |
| Gy Waldron | Characters |
| Mary Vernieu | Casting |
| John O'Brien | Screenplay |
| Nathan Barr | Original Music Composer |
| Jonathan L. Davis | Story |
| Jay Chandrasekhar | Director |
| Bruce Berman | Executive Producer |
| John O'Brien | Story |
| Myron Kerstein | Editor |
| Lisa Mae Fincannon | Casting |
| Hugo Dominguez | Digital Effects Supervisor |
| Michael J. Flynn | Greensman |
| Traci Kirshbaum | Set Decoration |
| Thomas A. Morris Jr. | Construction Coordinator |
| Donna Battersby Greene | Key Hair Stylist |
| Mark Johnston | Sound Recordist |
| Sterling Moore | Boom Operator |
| Meg Taylor | Dialogue Editor |
| Jason Piccioni | Visual Effects Supervisor |
| Michael J. Coo | Key Grip |
| Virginia McCollam | Location Manager |
| Artist W. Robinson | First Assistant Director |
| Chris Cornwell | Art Direction |
| Chris Bingham | Makeup Department Head |
| Sheri Kornhaber | Key Makeup Artist |
| Michael Sexton | Property Master |
| Scott D. Warner | Propmaker |
| Damon Bingham | Visual Effects Producer |
| Daniel Dietrich | Construction Foreman |
| Daniel Dupont | Leadman |
| Genevieve Tyrrell | Costume Design |
| Deborah Mills-Whitlock | Hair Department Head |
| Patrick J. Foley | Dialogue Editor |
| Robert Grieve | Sound Effects Editor |
| Kimberly R. McCord-Wilson | Dialogue Editor |
| Joel Shryack | Sound Effects Editor |
| Patrick R. Heffernan | Dolly Grip |
| Gary Hildebrand | Rigging Gaffer |
| Craig Henighan | Sound Effects Editor |
| Nic Harcourt | Music Supervisor |
| Leslie J. Kovacs | Gaffer |
| Gala Autumn | Costume Supervisor |
| John D'Aquino | Boom Operator |
| Scott Rogers | Stunt Coordinator |
| Darrin Prescott | Stunt Coordinator |
| Simon Dobbin | Art Direction |
| David Eckert | Set Designer |
| Bob Beher | Foley Editor |
| Lori J. Nelson | Visual Effects Producer |
| Lesley D. Wickham | Seamstress |
| Gregory King | Supervising Sound Editor |
| Brian Richards | Music Editor |
| Yann Delpuech | Sound Designer |
| Burt Dalton | Special Effects Supervisor |
| Sam Emerson | Still Photographer |
| Rebecca Fulton | Script Supervisor |
| Leslie Stevens | Production Coordinator |
| Robert Reed Altman | Camera Operator |
| Todd McMullen | Camera Operator |
| Heather Page | Camera Operator |
| Kristen Donaldson | Art Department Coordinator |
| Stephanie Girard | Set Designer |
| John G. Velez | Gaffer |
| Philip Lee | Additional Camera |
| Molly Grundman-Gerbosi | Assistant Costume Designer |
| Gerald Quist | Makeup Designer |
| Hank Amos | Stunts |
| Terry Garcia | Assistant Sound Editor |
| Randy Brown | Digital Compositors |
| Christopher M. Fisher | First Assistant Camera |
| Christopher Kuder | Carpenter |
| Gerald Autin | Grip |
| Michael Forte | Driver |
| Jonathan S. Morgan | Painter |
| Don Poole | Transportation Captain |
| Venus Kanani | Casting Associate |
| John Feinblatt | Picture Car Coordinator |
| Jack Reeves | Scenic Artist |
| Jennifer Brown | Set Medic |
| John M. Pisani | Unit Publicist |
| Ravi D. Mehta | Executive In Charge Of Production |
| Brett Boggs | Visual Effects |
| Jessie Holiday | Hairstylist |
| John Orlebeck | Transportation Coordinator |
| David Alvarez | Production Sound Mixer |
| Susan Salzano | Set Costumer |
| Reva Grantham | Craft Service |
| David E. Brown | Stand In |
| Terry Edinger | Production Accountant |
| John T. Reitz | Sound |
| Simone Almekias-Siegl | Makeup Artist |
| Brandon Beckman | Utility Stunts |
| J.J. Dalton | Set Production Assistant |
| Robert Gillis | Transportation Co-Captain |
| Mark Indig | Unit Production Manager |
| Bob Bates | Electrician |
| Trevor Carroll-Coe | Loader |
| Bobby Huber | Rigging Grip |
| Dempsey Tillman | Video Assist Operator |
| Darren King | ADR Supervisor |
| Christian Barr | Orchestrator |
| Lisa Dennis | Post Production Supervisor |
| Joey Gbur | Assistant Craft Service |
| Courtney Dane | Assistant Production Manager |
| Ben Kalina | Animation Coordinator |
| Rachel Goodlett Katz | Assistant Editor |
| Darrin Smith | Assistant Chief Lighting Technician |
| Leslie J. Kovacs | Chief Lighting Technician |
| Wendi Coates | Extras Casting Assistant |
| Chris Samp | Set Painter |
| Baris Attila | Title Designer |
| Mary Jo Lang | Foley Mixer |
| Jeffrey M. Hoffman | "B" Camera Operator |
| April McMorris | Digital Intermediate Producer |
| David Nico | Assistant Production Coordinator |
| Claudia Coleman | Costumer |
| Tara Martin | Location Assistant |
| Lisa Marie Hill | Production Secretary |
| Robert Dickerson Jr. | Additional Second Assistant Director |
| Ellen Lampl | Graphic Designer |
| Tommy Lohmann | "A" Camera Operator |
| Craig Kohtala | Best Boy Grip |
| John Ashker | Stunt Driver |
| Tracy Shields | Casting Assistant |
| Jay DeFelice | Location Production Assistant |
| Eric Gotthelf | ADR Mixer |
| Robin Batherson | Extras Casting |
| Amy Fegely | Key Set Costumer |
| J.D. Jacoby | Assistant Property Master |
| Ann G. Somogye | Additional Second Assistant Camera |
| Craig Fincannon | Location Casting |
| Kevin Duncan | Second Second Assistant Director |
| Gerard Martin | Camera Production Assistant |
| Everette Webber | Digital Intermediate Editor |
| Steven Baker | Music Consultant |
| Karen Scarborough | Payroll Accountant |
| Eddie Budd | Production Assistant |
| Doug Luberts | Visual Effects Assistant Editor |
| Alyson Dee Moore | Foley Artist |
| Sandy Holt | ADR Voice Casting |
| Jonathan Malden | Colorist |
| Dan Bradley | Second Unit Director |
| Chris Dawson | Digital Compositor |
| Jennifer P. Luther | First Assistant Accountant |
| Carole Humphreys | Second Assistant Accountant |
| Deanna Stadler | Second Assistant Director |
| Andy Dylan | Stunt Double |
| Jay Chandrasekhar | Additional Editing |
| Linda 'Sam' Glynn | Assistant Location Manager |
| Thomas Smaling | Dolly Grip |
| Tanner Foust | Stunt Driver |
| Frank M. Fleming | Set Dresser |
| Chad Stahelski | Stunt Double |
| David Leitch | Fight Choreographer |
| Troy Brown | Stunts |
| Tad Griffith | Stunts |
| Danny Epper | Stunts |
| Steve Kelso | Stunts |
| Tim Rigby | Stunts |
| Tommy J. Huff | Stunts |
