 | Jessica Alba als Sydney Wells |
 | Alessandro Nivola als Dr. Paul Faulkner |
 | Parker Posey als Helen Wells |
 | Rade Šerbedžija als Simon McCullough |
 | Mia Stallard als Little Girl |
 | Obba Babatundé als Dr. Haskins |
 | Danny Mora als Miguel |
 | Rachel Ticotin als Rosa Martinez |
 | Chloë Grace Moretz als Alicia Millstone |
 | Tamlyn Tomita als Mrs. Cheung |
 | Karen Elizabeth Austin als Mrs. Hillman |
 | Fernanda Romero als Ana Christina Martinez |
 | Heather Doerksen als Sickly Woman |
 | Tegan Moss als Teenage Girl |
 | Rachel Manera als Nurse (uncredited) |
| Sebastian Gutierrez | Screenplay |
| James H. Spencer | Production Design |
| Peter Chan | Executive Producer |
| Michael Paseornek | Executive Producer |
| Patrick Lussier | Editor |
| Doug Davison | Executive Producer |
| Jack L. Murray | Line Producer |
| Darren Miller | Executive Producer |
| Michelle Manning | Producer |
| Peter Block | Executive Producer |
| Tom Ortenberg | Executive Producer |
| Paula Wagner | Producer |
| Michael Dennison | Costume Design |
| Roy Lee | Executive Producer |
| Marco Beltrami | Music |
| Xavier Palud | Director |
| Don Granger | Producer |
| Mike Elliott | Executive Producer |
| Jeffrey Jur | Director of Photography |
| David Moreau | Director |
| Allen Hall | Special Effects Supervisor |
| Chris Gehrt | Casting Assistant |
| Martin Chávez | Thanks |
| Lance Gilbert | Stunts |
| Mic Rodgers | Second Unit Director |
| Owen Walstrom | Stunts |
| Sabine Varnes | Stunt Double |
| Ed Duran | Grip |
