 | Josh Hartnett als Zeke Tyler |
 | Elijah Wood als Casey Connor |
 | Clea DuVall als Stokely 'Stokes' Mitchell |
 | Jordana Brewster als Delilah Profitt |
 | Shawn Hatosy als Stan Rosado |
 | Laura Harris als Marybeth Louise Hutchinson |
 | Usher als Gabe Santora |
 | Salma Hayek Pinault als Nurse Rosa Harper |
 | Robert Patrick als Coach Joe Willis |
 | Famke Janssen als Miss Elizabeth Burke |
 | Piper Laurie als Mrs. Karen Olson |
 | Christopher McDonald als Mr. Frank Connor |
 | Bebe Neuwirth als Principal Valerie Drake |
 | Jon Stewart als Prof. Edward Furlong |
 | Daniel von Bargen als Mr. John Tate |
 | Summer Phoenix als F*** You Girl |
 | Jon Abrahams als F*** You Boy |
 | Danny Masterson als F*** Up #1 |
 | Wiley Wiggins als F*** Up #2 |
 | Susan Willis als Mrs. Jessica Brummel |
 | Pete Janssen als Eddie 'Meat' McIvey |
| Tina Rodriguez als Tattoo Girl |
 | Libby Villari als Casey's Mom |
| Harry Jay Knowles als Mr. Knowles |
| Donna Casey als Tina |
 | Louis Black als Mr. Lewis |
 | Eric Jungmann als Freshman #1 |
| Chris Viteychuk als Freshman #2 |
| Jim Johnston als P.E. Teacher |
 | Duane Martin als Officer #1 |
 | Katherine Willis als Officer #2 |
 | Mike Lutz als Hornet Mascot |
| Douglas Aarniokoski als Brun Coach |
| Michelle Fairbanks als Student |
 | Kidada Jones als Venus |
| Heath Young als Student / Football Fan (uncredited) |
| Michael Bliss als News Camera Man (uncredited) |
| R.C. Keene als Football Fan (uncredited) |
| Eric Vespe als Geek (uncredited) |
| Brad Schreiber als Hornet Football Player (uncredited) |
| Tony Tamayo als Football Game Attendee (uncredited) |
 | Cassandra L. Small als School Office Clerk (uncredited) |
| Rick Olmos als Football Fan (uncredited) |
| Dannie Helen Loraine Knowles als Tatooed Pierced Girl #2 (uncredited) |
| Jason May als Biology Student (uncredited) |
| Marco Beltrami | Original Music Composer |
| Bob Weinstein | Executive Producer |
| Tamara Smith | Producer |
| Robert Rodriguez | Editor |
| Robert Rodriguez | Director |
| Robert Rodriguez | Producer |
| Enrique Chediak | Director of Photography |
| Kevin Williamson | Screenplay |
| Harvey Weinstein | Executive Producer |
| Elizabeth Avellan | Producer |
| Bill Scott | Line Producer |
| Anne McCarthy | Casting |
| Mary Vernieu | Casting |
| Michael T. Boyd | Costume Design |
| Kelly Nelson | Hairstylist |
| Jeanette Scott | Set Decoration |
| Justin Ditter | Wigmaker |
| Chris Hanson | Makeup Effects |
| Don Malot | Makeup Artist |
| Cary White | Production Design |
| Bridget Cook | Hairstylist |
| Ed Vega | Art Direction |
| Alan Tuskes | Makeup Effects |
| Melissa Forney | Hairstylist |
| Ermahn Ospina | Makeup Artist |
| David Wilt | Construction Coordinator |
| Richard Hymns | Sound Effects Editor |
| John Frick | Assistant Art Director |
| Jana Vance | Foley |
| Jon H. Lewis | Gaffer |
| Michael Semanick | Sound Re-Recording Mixer |
| Brian Jennings | Visual Effects Supervisor |
| David McGill | Steadicam Operator |
| Dennie Thorpe | Foley |
| Phil Benson | Supervising Sound Editor |
| Rico Torres | Still Photographer |
| Jay B. Richardson | Music Editor |
| Steve Boeddeker | Sound Designer |
| Molly Murray | Art Department Coordinator |
| Dawn M. Baker | Scenic Artist |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Daniel Leduc | Digital Effects Supervisor |
| Peggy Mulloy | Unit Publicist |
| Daniel Sperry | Dolby Consultant |
| Robert Rodriguez | Sound Re-Recording Mixer |
| John McLeod | Special Effects Coordinator |
| Yvonne Wilburn | Set Costumer |
| Cecil D. Evans | Transportation Coordinator |
| Teresa Eckton | Sound Effects Editor |
| Stanley Moore | Costume Supervisor |
| Bill Abbott | Music Editor |
| Kosta Saric | Visual Effects Editor |
| Steffen M. Wild | Digital Effects Supervisor |
| Lou Ann Quast | Script Supervisor |
| Bob Brown | Stunt Coordinator |
| Robert Rodriguez | Camera Operator |
| Kelley A. Hankins | Scenic Artist |
| David C. Hughes | Sound Effects Editor |
| Kyrsten Mate | Sound Effects Editor |
| Sue Fox | ADR Editor |
| Claire Sanfilippo | Dialogue Editor |
| Dianna Stirpe | Dialogue Editor |
| Larry Schalit | ADR Editor |
| Steve Joyner | Property Master |
| Jack Colmenero | Set Dresser |
| Randy Huke | Set Decoration Buyer |
| Randy Severs | Set Dresser |
| Nicolas Cotta | VFX Artist |
| David Wechter | Story |
| Bruce Kimmel | Story |
| Jennifer Caputo | Stunts |
| Jon H. Epstein | Stunts |
| Eileen Weisinger | Stunts |
| Joe Bucaro III | Stunts |
| Sandy Berumen | Stunts |
