 | Hugh Jackman als Tomás / Tom Creo / Tommy |
 | Rachel Weisz als Isabel / Izzi Creo |
 | Ellen Burstyn als Dr. Lillian Guzetti |
 | Mark Margolis als Father Avila |
 | Stephen McHattie als Grand Inquisitor Silecio |
 | Fernando Hernández als Lord of Xibalba |
 | Cliff Curtis als Captain Ariel |
 | Sean Patrick Thomas als Antonio |
 | Donna Murphy als Betty |
 | Ethan Suplee als Manny |
 | Richard McMillan als Henry |
 | Lorne Brass als Dr. Alan Lipper |
 | Abraham Aronofsky als Lab Technician |
| Renee Asofsky als Lab Technician |
| Anish Majumdar als Dr. Spencer |
 | Janique Kearns als Young Nurse |
 | Boyd Banks als Dominican Monk |
 | Alex Bisping als Foot Soldier Del Toro |
| Kevin Kelsall als Foot Soldier Rivera |
| Patrick Vandal als Foot Soldier Galleano |
 | Marcello Bezina als Foot Soldier Borjes |
| Hugo Salvador Gutierrez Aguilar als Mayan Warrior |
| Eric Carmelo Valenzuela Batz als Mayan Warrior |
| Elfego Vinicio Pena Castellanos als Mayan Warrior |
| Jose Maria Tol Chan als Mayan Warrior |
| Benjamin Panjoj Cortez als Mayan Warrior |
| Juan Salvador Lares als Mayan Warrior |
| Jose Alfredo Conoz Macario als Mayan Warrior |
| Tomas Tol Nix als Mayan Warrior |
| Luis Alfredo Yac Noj als Mayan Warrior |
| Mateo Martin Perez als Mayan Warrior |
| Edson Vasquez Pixabaj als Mayan Warrior |
| Marvin Leonardo Raxtun Raxtun als Mayan Warrior |
| Tomas Morales Sacquic als Mayan Warrior |
| Santos Ajic Sapon als Mayan Warrior |
| Xaijil Sicajan als Mayan Warrior |
| Manuel Antonio Salvador Tol als Mayan Warrior |
| Tomas Salvador Tol als Mayan Warrior |
| Tomas Augustin Canil Ventura als Mayan Warrior |
| Carlos Enrique Ramos Xalcut als Mayan Warrior |
| Octavio Guadelupe Zabala Xitamul als Mayan Warrior |
| Darren Aronofsky | Director |
| Darren Aronofsky | Author |
| Clint Mansell | Original Music Composer |
| Matthew Libatique | Director of Photography |
| Ari Handel | Author |
| Arnon Milchan | Producer |
| Iain Smith | Producer |
| Nick Wechsler | Executive Producer |
| Jay Rabinowitz | Editor |
| Mary Vernieu | Casting |
| James Chinlund | Production Design |
| Renée April | Costume Design |
| Darren Aronofsky | Screenplay |
| Nicolas Lepage | Art Direction |
| Jean-Pierre Paquet | Art Direction |
| Martine Giguère-Kazemirchuk | Set Decoration |
| Daniel Hamelin | Set Decoration |
| Philippe Lord | Set Decoration |
| Jean-Jacques Dion | Hairstylist |
| Jocelyne Bellemare | Makeup Artist |
| Julie Casault | Makeup Artist |
| Natacha Antiglio | Art Department Coordinator |
| Simon Chamberland | Property Master |
| Helene Lamarre | Art Department Coordinator |
| Camille Parent | Assistant Art Director |
| Yuan-Frédéric D'Amour | Greensman |
| Raymond J. Légaré | Greensman |
| Frédéric Amblard | Set Designer |
| Brent Lambert | Set Designer |
| Félix Larivière-Charron | Set Designer |
| Jean-Pierre Lavoie | Set Designer |
| Alex Touikan | Set Designer |
| Jill Purdy | ADR & Dubbing |
| Nelson Ferreira | Dialogue Editor |
| Steve Baine | Foley |
| Mike Patrick | Sound Recordist |
| Stephen Barden | Sound Designer |
| Brian Emrich | Sound Designer |
| Craig Henighan | Sound Designer |
| Dominick Tavella | Sound Re-Recording Mixer |
| Alex Bullick | First Assistant Sound Editor |
| Louis Craig | Special Effects Coordinator |
| Stephen Gilbert | Special Effects Coordinator |
| Jeremy Oddo | Animation |
| Philippe Sylvain | Animation |
| Thai Son Doan | Animation |
| Jenny Foster | Visual Effects Producer |
| Michel Héroux | Visual Effects Producer |
| Persis Reynolds | Visual Effects Producer |
| Mark G. Soper | Visual Effects Producer |
| Andrew Weisblum | Visual Effects Editor |
| Laurent M. Abecassis | Visual Effects Supervisor |
| Henrik Fett | Visual Effects Supervisor |
| Raymond Gieringer | Visual Effects Supervisor |
| Matthew Gratzner | Visual Effects Supervisor |
| Gunnar Hansen | Visual Effects Supervisor |
| Phil Jones | Visual Effects Supervisor |
| Louis Morin | Visual Effects Supervisor |
| Peter Oberdorfer | Visual Effects Supervisor |
| Marc Désourdy | Stunt Coordinator |
| François Daignault | Camera Operator |
| Sylvaine Dufaux | Second Unit Cinematographer |
| Takashi Seida | Still Photographer |
| Pete Romano | Underwater Camera |
| John Lewin | Gaffer |
| Gilles Fortier | Rigging Gaffer |
| Robin D. Cook | Casting |
| Elfego Vinicio Pena Castellanos | Casting |
| Blanche Boileau | Costume Supervisor |
| Amy Pawlowski | Digital Intermediate |
| Lorene Simpson | Digital Intermediate |
| Warren Langford | First Assistant Editor |
| Jennifer Apel | First Assistant Editor |
| Nic Ratner | Music Editor |
| Michel Mollicone | Transportation Coordinator |
| Kimi Webber | Script Supervisor |
| Jess Platt | Dialect Coach |
| Susan Hegarty | Dialect Coach |
| Dow Griffith | Location Manager |
| Pierre Brunet | Location Manager |
| Christian Biron | Location Manager |
| Cara Leibovitz | Unit Publicist |
| Isabelle Guay | Supervising Art Director |
| Patrick Rousseau | Sound Mixer |
| Jason Cavalier | Fight Choreographer |
| Myron Hoffert | First Assistant Director |
| Anabelle Berkani | Third Assistant Director |
| Johanne Caporicci | Second Assistant Director |
| Jeremy Dawson | Second Unit Director |
| Robbie Ditchburn | First Assistant Director |
| Martin Doepner | Additional Third Assistant Director |
| Emilie Malo | Third Assistant Director |
| Liam Kiernan | Assistant Location Manager |
