 | Jonathan Majors als Nat Love |
 | Idris Elba als Rufus Buck |
 | Regina King als Trudy Smith |
 | Zazie Beetz als Stagecoach Mary |
 | Delroy Lindo als Bass Reeves |
 | Danielle Deadwyler als Cuffee |
 | LaKeith Stanfield als Cherokee Bill |
 | Edi Gathegi als Bill Pickett |
 | RJ Cyler als Jim Beckwourth |
 | Deon Cole als Wiley Escoe |
 | Julio Cesar Cedillo als Jesus Cortez |
 | Damon Wayans Jr. als Monroe Grimes |
 | Woody McClain als Clyde Grimes |
 | Jacobi Howard als Angel |
 | Tait Fletcher als Biggest Man on the Train |
 | Dylan Kenin als General Abbott |
 | Andria B Langston als Bank Teller |
 | Ernest Marsh als Cowboy |
| Chanel Mack als Lady of the Night |
| Tracy Obonna als Lady of the Night |
 | Howard Ferguson Jr. als Prison Lieutenant |
| Bonita King als Bank Patron |
 | Mickey Dolan als Jake Abbott |
 | Michael Beach als Mr. Love |
 | DeWanda Wise als Eleanor Love |
 | Chase W. Dillon als Young Nat |
| Marissa Freeman als Lady of the Night |
 | Sadiqua Bynum als Eleanor Love |
 | Zacciah Hanson als Prisoner Guard |
| DyNiesha Lysette Whitfield als Lady of the Night |
| David Hight als Train Server |
 | Stephanie Hill als Train Passenger |
 | Vic Browder als Prison Guard |
| Ivan Lee Holmes als Shopkeeper |
| Michael E. Stogner als Maysville Citizen |
| Angie Jenkins als Lady of the Night |
 | Steve Corona als Maysville Bank Manager |
 | Peyton Jackson als Woody |
 | J. Nathan Simmons als Maysville Citizen |
| Terrence Clowe als Zeke |
 | Manny Rubio als Father Esparza |
| Nicholas G. Sims als Douglastown Cowboy (uncredited) |
 | Aahkilah Cornelius als Blue Lady |
 | Mark Rhino Smith als Carson |
| Jeymes Samuel | Director |
| Lawrence Bender | Producer |
| Jay-Z | Producer |
| James Lassiter | Producer |
| Jeymes Samuel | Producer |
| Boaz Yakin | Screenplay |
| Jeymes Samuel | Screenplay |
| Jay-Z | Executive Producer |
| G. Mac Brown | Executive Producer |
| Mihai Malaimare Jr. | Director of Photography |
| Victoria Thomas | Casting |
| Martin Whist | Production Design |
| Matthew Gatlin | Art Direction |
| Gregory S. Hooper | Art Direction |
| Jay Hart | Set Decoration |
| Cynthia La Jeunesse | Set Decoration |
| Antoinette Messam | Costume Design |
| Shutchai Tym Buacharern | Makeup Department Head |
| Robert Kato DeStefan | Makeup Artist |
| Jon Shroyer | Makeup Artist |
| Nysh Yellowhorse | Makeup Artist |
| Chris F. Moore | Visual Effects |
| Kris Wood | Visual Effects Supervisor |
| Richard King | Supervising Sound Editor |
| Richard King | Sound Designer |
| Randy Torres | Sound Editor |
| Tom Eagles | Editor |
| Drew Burrell | Additional Hairstylist |
| Sabrina Cruz Castro | Key Makeup Artist |
| Tayari Edwards | Hairstylist |
| Sincere Gilles | Hairstylist |
| Amber Glasrud | Assistant Makeup Artist |
| Araxi Lindsey | Hair Department Head |
| Rebecca Adams | Post Production Supervisor |
| Lindsay Feldman | Production Manager |
| G. A. Aguilar | Second Unit Director |
| Kate Hennessy | Second Assistant Director |
| Ricky R. Weaver | Second Second Assistant Director |
| Jack Blanchard | Leadman |
| Lorrie Campbell | Set Designer |
| Sage Emmett Connell | On Set Dresser |
| Eric Fehlberg | Set Designer |
| Severino Gonzales | Props |
| Darryl Henley | Storyboard Artist |
| Sarah Iha | Set Dresser |
| Dale Lotreck | Painter |
| Cierra Madison | Set Designer |
| Roberta Marquez Seret | Art Department Coordinator |
| Ron Novak | Propmaker |
| Chris Painter | Set Dresser |
| Greg Papalia | Set Designer |
| Eileen Reynolds | Set Painter |
| Loren Schoel | Set Painter |
| Phil Shirey | Leadman |
| Dwayne Turner | Storyboard Artist |
| Tom Wagman | Set Designer |
| Colin Zaug | On Set Dresser |
| David Bach | Dialogue Editor |
| Mike Horton | Foley Artist |
| Thomas Jones | Dialogue Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Michael W. Mitchell | Sound Effects Editor |
| Anthony Ortiz | Sound Mixer |
| Jeffrey Roy | ADR Mixer |
| Douglas Shamburger | Boom Operator |
| Roland N. Thai | Sound Effects Editor |
| David P.I. James | Visual Effects Producer |
| Yusuf Hasan | Digital Compositor |
| Sara Pedramnia | Visual Effects Coordinator |
| Shawn Wayman | Visual Effects Coordinator |
| Darrell Burgess | Special Effects Technician |
| Brandon K. McLaughlin | Special Effects Technician |
| Moore Brian | Special Effects Technician |
| Richard Bucher | Stunt Coordinator |
| Dylan Hice | Stunts |
| Quinn Early | Stunts |
| Brian Brown | Utility Stunts |
| Sandy Fletcher | Utility Stunts |
| Gene Freeman | Utility Stunts |
| Denisha Gillespie | Utility Stunts |
| Maria Bentfield | Key Costumer |
| Brian Barela | Set Costumer |
| Audrey Eisner | Costumer |
| Michelle Kelly | Set Costumer |
| Jill Machlis | Key Costumer |
| Claudia Sarbu | Costume Supervisor |
| Rowan Stanland | Location Scout |
| Rebecca Puck Stair | Location Manager |
| Samuel James Bellamy | Assistant Editor |
| Steven Mates | VFX Editor |
| Clint Bennett | Music Editor |
| Michelle Kuznetsky Silverman | Music Supervisor |
| Denise Brady | Best Boy Grip |
| Colin Montgomery | Grip |
| Mackie Roberts | Key Grip |
| Ryan Bushman | Drone Cinematographer |
| Jazmin Harvey | Camera Loader |
| Scott Kuipers | Lighting Technician |
| Lamarr Gray | Gaffer |
| Jeymes Samuel | Music |
| Gary Archer | Prosthetics |
| Tinisha Meeks | Key Hair Stylist |
| Eric Shamm Watson | Stunt Double |
| Keith Woulard | Stunt Coordinator |
| Ed Duran | Stunts |
