 | Matt Damon als Mark Whitacre |
 | Lucas McHugh Carroll als Alexander Whitacre |
 | Eddie Jemison als Kirk Schmidt |
 | Rusty Schwimmer als Liz Taylor |
 | Craig Ricci Shaynak als Discouraged Foreman |
 | Tom Papa als Mick Andreas |
 | Rick Overton als Terry Wilson |
 | Melanie Lynskey als Ginger Whitacre |
 | Thomas F. Wilson als Mark Cheviron |
 | Scott Bakula als Brian Shepard |
 | Scott Adsit als Sid Hulse |
 | Ann Dowd als Kate Medford |
 | Allan Havey als FBI Supervisor Dean Paisley |
 | Howie Johnson als Rusty Williams |
 | Joel McHale als Robert Herndon |
 | Nick Craig als Kid at Pool #1 |
| Cody Puckett als Kid at Pool #2 |
 | Andy Daly als Marty Allison |
 | David Campbell als Budweiser Client Representative |
| Carolyn R. Feltner als Budweiser Receptionist |
 | J.P. Gillain als Zurich Bank Security Officer |
 | Elena Eustache als Zurich Bank Receptionist |
 | John Hans Tester als Peter Dreyer |
 | Ludger Pistor als Reinhard Richter |
 | Rome Kanda als Hirokazu Ikeda |
| Yoshio Be als Kazutoshi Yamada |
 | Raymond Ma als Kanji Mimoto |
| Hervé Deschamps als Philippe Rollier |
| Pascal Ifri als Alain Crouy |
 | Ann Cusack als Robin Mann |
 | Dann Seki als Joon Mo Suh |
 | Jayden Lund als James Mutchnik |
 | Chic Daniel als FBI Agent at Raid |
 | Joe Chrest als Visiting Client |
| J.D. Mathein als Phone Agent |
| William Marsh als FBI Special Agent Ken Temples |
 | Tom Smothers als Dwayne Andreas |
 | Clancy Brown als Aubrey Daniel |
 | Bob Zany als John Dowd |
 | Tony Hale als James Epstein |
 | Richard Steven Horvitz als Bob Zaiderman |
 | Tara Barrett als Reporter #1 |
 | Tim Cain als Reporter #2 |
 | Ken Frye als Reporter #3 |
 | Huey Freeman als Reporter #4 |
 | Brian Gallivan als Ron Henkoff |
 | Daniel Hagen als Scott Roberts |
 | Patton Oswalt als Ed Herbst |
 | Samantha Albert als Mary Spearing |
 | Jimmy Brogan als Dr. Derek Miller |
 | Paul F. Tompkins als FBI Special Agent Anthony D'Angelo |
 | Adam Paul als FBI Special Agent Michael Bassett |
 | Wayne Pére als Sheldon Zenner |
| Scott England als Local News Anchor |
 | Joshua Funk als FBI Special Agent Robert Grant |
 | Candy Clark als Mark Whitacre's Mother |
 | Frank Welker als Mark Whitacre's Father |
 | Larry Clarke als Whitacre's Second Attorney |
 | Dick Smothers als Judge Harold Baker |
 | Steve Seagren als Correctional Officer |
 | Arden Myrin als Sarah Scott (uncredited) |
| Steven Soderbergh | Director |
| Scott Z. Burns | Screenplay |
| Stephen Mirrione | Editor |
| Steven Soderbergh | Director of Photography |
| Marvin Hamlisch | Original Music Composer |
| Kurt Eichenwald | Book |
| John Robotham | Stunt Coordinator |
| Rick LeFevour | Stunt Coordinator |
| Claudette Barius | Still Photographer |
| Missy Cohen | Music Editor |
| Adrienne Hamalian-Mangine | Script Supervisor |
| Doug J. Meerdink | Production Design |
| Carmen Cuba | Casting |
| Shoshana Rubin | Costume Design |
| Dennis Towns | Production Sound Mixer |
| Larry Blake | Sound Re-Recording Mixer |
| Larry Blake | Supervising Sound Editor |
| Matt Coby | Sound Editor |
| Sandy Kenyon | Costume Supervisor |
| Gregory Jacobs | Producer |
| Howard Braunstein | Producer |
| George Clooney | Executive Producer |
| Kurt Eichenwald | Producer |
| Jennifer Fox | Producer |
| Michael Jaffe | Producer |
| Michael London | Executive Producer |
| Jeff Skoll | Executive Producer |
| Michael Polaire | Co-Producer |
| Gregory Jacobs | First Assistant Director |
| Jody Spilkoman | Second Assistant Director |
| Christine Beveridge | Makeup Artist |
| Barbara Cantu | Key Hair Stylist |
| LaTrice L. Edwards | Makeup Artist |
| Kay Georgiou | Hairstylist |
| Jules Holdren | Hairstylist |
| Connie Kallos | Hairstylist |
| Chris Lyons | Special Effects Makeup Artist |
| Elisa Marsh | Makeup Department Head |
| Gloria Pasqua Casny | Hair Department Head |
| Marsha Shearrill | Key Makeup Artist |
| Vicki Vacca | Makeup Artist |
| Rebecca Wachtel | Makeup Artist |
| Gilles Castera | Production Manager |
| Renee Confair | Production Supervisor |
| David Kirchner | Post Production Supervisor |
| Robin Le Chanu | Production Manager |
| Mark Scoon | Executive In Charge Of Production |
| Gil Kenny | First Assistant Director |
| Lynne Martin | Second Second Assistant Director |
| Lauren Pasternack | Assistant Director Trainee |
| Norman Alatorre | Propmaker |
| Colin Alexander | Propmaker |
| Andrew Alward | Art Department Assistant |
| Tim Alward | Art Department Assistant |
| Dawn Brown | Set Designer |
| Joanna Bush | Art Designer |
| Gregory Byrne | Set Dresser |
| Alvin S. Cabrinha Jr. | Property Master |
| Robert J. Carlyle | Construction Coordinator |
| Walsh Carvalho | Set Dresser |
| Adolfo Castanon | Greensman |
| Genelle Ciccarelli | Set Decorating Coordinator |
| Scott Ellsworth | Propmaker |
| Richard Ewan | Painter |
| Jimmy Flores | Propmaker |
| Stephen Gibson | Assistant Property Master |
| Thomas J. Glynn | Set Dresser |
| Martin Grimes | Set Dresser |
| Jeffrey Paul Johnson | Property Master |
| Andrew Calma Jr | Painter |
| Paul Knubley | Set Dresser |
| Chris Larsen | Set Dresser |
| Craig K. Lewis | Set Dresser |
| Jamie Litwak | Propmaker |
| James R. Lord | Propmaker |
| Quentin Matthys | Construction Foreman |
| Christopher Morente | Greensman |
| Timothy Mullennix | Propmaker |
| Nelly Nahon | Graphic Designer |
| Matthew J. Norskog | On Set Dresser |
| Roderick Nunnally | Paint Coordinator |
| Michael Okuda | Graphic Designer |
| Jason Perrine | Art Department Assistant |
| Leia Pratapas | Art Department Coordinator |
| Shane Reed | Leadman |
| Francis J. Roix | Carpenter |
| Scott Schutzki | Set Dresser |
| Alex Sessing | Greensman |
| Julie Smith | Assistant Set Decoration |
| Gary Stel | Propmaker |
| Scott Troha | Leadman |
| Jane Wuu | Set Designer |
| Jim Tudor | Set Dresser |
| Clark Woodman | Set Dresser |
| Sean Byrne | Sound Recordist |
| Barry Donnelly | ADR Recordist |
| Dawn Fintor | Foley Artist |
| Javier M. Hernández | Boom Operator |
| Steve La Fayette | Utility Sound |
| François Musy | Sound |
| David Puntener | Boom Operator |
| Marcus Ricaud | Utility Sound |
| Brian Seagrave | Audio Post Coordinator |
| Mark Shehab | ADR Recordist |
| Alicia Stevenson | Foley Artist |
| Billy Theriot | Assistant Sound Editor |
| Gunter Anderson | Special Effects Technician |
| Jared Baker | Special Effects Technician |
| Robert Bolanowski | Special Effects Technician |
| Ron Bolanowski | Special Effects Coordinator |
| Darrell Burgess | Special Effects Technician |
| Bob Everett | Special Effects Technician |
| Bob Shelley | Special Effects Technician |
| Daniel Yates | Special Effects Technician |
| Gary Abrahamian | Lead Animator |
| Heather Elisa Hill | Visual Effects Production Manager |
| Lisa Maher | Visual Effects Producer |
| Kama Moiha | Compositor |
| Liz Radley | CG Supervisor |
| Chris Ryan | CG Supervisor |
| Thomas J. Smith | Visual Effects Supervisor |
| Chris B. Schnitzer | Visual Effects Director |
| Sean Graham | Stunts |
| Tabby Hanson | Stunts |
| Rick LeFevour | Stunts |
| Tom Lowell | Stunt Double |
| Daniel Maldonado | Stunt Driver |
| Scott Philyaw | Stunt Driver |
| Stephen W. Schriver | Stunts |
| Henry Cantor | Electrician |
| Gregory Doi | Electrician |
| Greg Fausak | Best Boy Grip |
| John-Anthony Gargiulo | Dolly Grip |
| Jeroen Hendriks | Camera Technician |
| Steve Irwin | Playback Coordinator |
| Nicholas Kaat | Assistant Chief Lighting Technician |
| April Kelley | Second Assistant Camera |
| Cyril Kuhnholtz | Key Grip |
| Steven Meizler | First Assistant Camera |
| John Joseph Minardi | Key Grip |
| Glenn E. Moran | Rigging Gaffer |
| Patrick B. O'Brien | Camera Operator |
| Michael J. Schwartz | Electrician |
| Paul Toomey | Second Assistant Camera |
| Peter Walts | Chief Lighting Technician |
| Shelby Cherniet | Casting Associate |
| Helen Geier | Casting Associate |
| Mike Ketcher | Extras Casting |
| Rich King | Extras Casting |
| Becca McCracken | Casting Associate |
| Claire Simon | Casting Associate |
| Teresa Thoma | Casting Associate |
| Erin Stewart Tiedje | Extras Casting Assistant |
| Jonathan Kinnas | Extras Casting |
| Jessica Albertson | Set Costumer |
| Danielle Baker | Costumer |
| Rebecca M. Graves | Costume Assistant |
| Brad Holtzman | Key Costumer |
| Valerie T. O'Brien | Costumer |
| Barnaby Smith | Costumer |
| Melissa Stinson | Set Costumer |
| Cat Dawson | Wardrobe Assistant |
| Matt Absher | First Assistant Editor |
| Corey Bayes | Assistant Editor |
| Matt Blackshear | Colorist |
| Jimmy Fusil | Digital Intermediate Producer |
| Nat Jencks | Digital Intermediate Editor |
| Barbara Jean Kearney | Digital Intermediate Producer |
| Tim Stipan | Digital Colorist |
| Michael P. Whipple | Digital Intermediate Data Wrangler |
| Lee Wimer | Color Timer |
| Benjamin Sutor | Digital Intermediate Editor |
| Mike Barry | Assistant Location Manager |
| Ron Durham | Assistant Location Manager |
| Liz Goldsmith | Assistant Location Manager |
| Al Huynh | Location Assistant |
| Arnaud Kaiser | Location Manager |
| Ken Lavet | Location Manager |
| Arnaud Mathey-Dreyfus | Location Scout |
| Guy Morrison | Assistant Location Manager |
| Stefan Nikolov | Location Scout |
| Bernadette Wilson | Location Assistant |
| Peter Erskine | Musician |
| Larry Hochman | Orchestrator |
| John Moses | Musician |
| Laura Sherman | Musician |
| Tim Starnes | Music Editor |
| William O. Hunter | Art Direction |
| David Scott | Art Direction |
| Daniel B. Clancy | Set Decoration |
