 | Thomas Jane als Neal Cassady |
 | Keanu Reeves als Harry |
 | Adrien Brody als Ben |
 | John Doe als Lewis |
 | Claire Forlani als Joan |
 | Jim Haynie als Jerry |
 | Marg Helgenberger als Lizzy |
 | Lucinda Jenney als Rosie Trickle |
 | Gretchen Mol als Mary Greenway |
 | Pat McNamara als Father Fletcher |
 | Kate Williamson als Nurse Waring |
 | Cristine Rose als Mrs. Greenway |
 | Meadow Sisto als Sarah |
 | Amy Smart als Jeananne |
 | Alexandra Holden als Vicky |
 | Clark Gregg als Cop #1 |
 | Joe Charbanic als Cop #2 |
| Edward Bates als Player #1 |
 | Ted Henning als Guard #1 |
 | Josh Randall als Guard #2 |
| Stephen T. Kay | Director |
| Bobby Bukowski | Director of Photography |
| Dorian Harris | Editor |
| Amy Ancona | Production Design |
| Rachel Kamerman | Art Direction |
| Melissa M. Levander | Set Decoration |
| Denise Wingate | Costume Design |
| Christopher Violette | Music Supervisor |
| Tyler Bates | Original Music Composer |
| Laurel Smith | Casting Director |
| Neal Cassady | Book |
| Stephen T. Kay | Writer |
| Jennifer Shankman | Co-Producer |
| Estelle Lasher | Co-Executive Producer |
| Elizabeth Robinson | Co-Executive Producer |
| Peter Abrams | Executive Producer |
| Robert L. Levy | Executive Producer |
| J.P. Guerin | Executive Producer |
| Peter Locke | Executive Producer |
| Donald Kushner | Executive Producer |
| Lawrence Mortorff | Executive Producer |
| Louise Rosner-Meyer | Producer |
| Edward Bates | Producer |
| Glade Quinn | Stunts |
| Louise Rosner-Meyer | Unit Production Manager |
| William Paul Clark | First Assistant Director |
| Sholto J. Roeg | Second Assistant Director |
| Michael J. Latino | First Assistant Camera |
| Theo Pingarelli | Second Assistant Camera |
| Jeremy Wheeler | Camera Loader |
| Dale Robinette | Still Photographer |
| Mark Weingarten | Sound Mixer |
| Roger Stevenson | Sound Mixer |
| Jeff Enden | Boom Operator |
| Scott Peterson | Script Supervisor |
| Dana L. Koellner | Production Coordinator |
| Pilar Savone | Second Second Assistant Director |
| Joe Charbanic | Second Second Assistant Director |
| Lisa Vazquez | Assistant Art Director |
| Eden Barr | Assistant Set Decoration |
| Darla R. Hitchcock | On Set Dresser |
| John Casey | Costume Supervisor |
| Anita Cabada | Set Costumer |
| Lanny Sykes | Set Costumer |
| Suzanne Diaz | Key Makeup Artist |
| Laura De Luisa | Hairstylist |
| Lynn Rodgers | Hairstylist |
| Jennifer Turchi Nigh | Makeup & Hair |
| Laura Machieraldo | Makeup & Hair |
| Laura Markert | Makeup & Hair |
| Sherwood Jones | Post Production Supervisor |
| Megan F. Ring | Post Production Supervisor |
| Anthony Santiago | Assistant Editor |
| Leonard Marcel | Supervising Sound Editor |
| Leonard Marcel | Sound Designer |
| Sidney Kohn | Assistant Sound Editor |
| Rick Knowlton | Foley Mixer |
| Joan Rowe | Foley Artist |
| Alan Kerr | Foley Artist |
| Larry Schalit | Dialogue Editor |
| Larry Schalit | ADR Editor |
| Andrew DeCristofaro | Sound Supervisor |
| Jeff Vaughn | ADR Mixer |
| Eric Thompson | ADR Mixer |
| Brandon Walker | ADR Recordist |
| Peter S. Carlstedt | Sound Re-Recording Mixer |
| Marc Fishman | Sound Re-Recording Mixer |
| Ken Teaney | Sound Re-Recording Mixer |
| Joel E. Smith | Sound Re-Recording Mixer |
| Ezequiel Salas | Sound Re-Recording Assistant |
| Bill Black | Music Editor |
| Jeanne Lin | Music Coordinator |
| Rick Page | Second Assistant Camera |
| Carla Woodmanse | Production Coordinator |
| Mari Raymer | Second Second Assistant Director |
| Cate Praggastis | Extras Casting |
| Mike Bachman | Picture Car Coordinator |
| Fenton Quinn | Technical Advisor |
| Dave Whitten | Color Timer |
