 | Charlie Hunnam als Percival Fawcett |
 | Robert Pattinson als Henry Costin |
 | Sienna Miller als Nina Fawcett |
 | Tom Holland als Jack Fawcett |
 | Angus Macfadyen als James Murray |
 | Edward Ashley als Arthur Manley |
 | Clive Francis als Sir John Scott Keltie |
 | Ian McDiarmid als Sir George Goldie |
 | Franco Nero als Baron de Gondoriz |
 | Matthew Sunderland als Dan |
 | Johann Myers als Willis |
 | Daniel Huttlestone als Brian Fawcett (15 Yr Old) |
 | Harry Melling als William Barclay |
 | Pedro Coello als Tadjui |
 | Aleksandar Jovanović als Urquhart |
 | Yelena Solovey als Madame Kumel |
 | Bobby Smalldridge als Jack Fawcett (7 Yr Old) |
 | Tom Mulheron als Jack Fawcett (3 Yr Old) |
| Nathaniel Bates Fisher als Brian Fawcett (7 Yr Old) |
 | Murray Melvin als Lord James Bernard |
 | Michael Jenn als Brigd-General Sidney Thornton |
 | Michael Ford-FitzGerald als Hunt Leader |
 | Frank Clem als Texas Gunman |
 | Bethan Coomber als Joan Fawcett (7 Yr Old) |
 | David Calder als Secretary Bryce |
 | Stacy Shane als American Reporter |
 | Pat Mooney als Random Scientist 3 |
 | Colin Carnegie als Random Scientist 2 |
 | Anthony Boyle als Trench Runner |
| Neil Bromley als Reporter 3 |
| Bill Hurst als Reporter 1 |
| Richard Croxford als Officer Thomas Busby |
 | Louise Parker als Random Woman |
| Jose Pereira als Chief Guarayo |
 | Gustavo Duque als Crew Member |
 | Fernando Vigui als Diminutive Latino Man |
 | Nicholas Agnew als John Coundley |
| Robert Fawsitt als Random Man at Port |
| Patrick McBrearty als Whipping Officer |
| Gary Crossan als Waiter @ Savage Club |
 | Niall Cusack als Random Scientist |
 | Nick Sampson als Doctor |
 | Ruairí Heading als Other Soldier |
| David Coon als Random Scientist 4 |
| James Gray | Director |
| James Gray | Screenplay |
| Brad Pitt | Executive Producer |
| Jeremy Kleiner | Producer |
| Anthony Katagas | Producer |
| Dede Gardner | Producer |
| James Gray | Producer |
| Dale Armin Johnson | Producer |
| Juan Pablo Rincón | Local Casting |
| Catriona Dickie | Casting Assistant |
| Kate Ringsell | Casting |
| Carla Stronge | Casting |
| Vanessa Baker | ADR Voice Casting |
| Darius Khondji | Director of Photography |
| Morag Cameron | Script Supervisor |
| Christopher Spelman | Music |
| John Axelrad | Editor |
| Lee Haugen | Editor |
| Sonia Grande | Costume Design |
| Gabriella Loria | Assistant Costume Designer |
| Wanda Morales | Assistant Costume Designer |
| Claire Leese | Costume Coordinator |
| Regina Calvo | Costume Supervisor |
| Nana Fischer | Hair Designer |
| Aidan Bradley | Hairstylist |
| Sandra O'Brien | Hairstylist |
| Cathy Prior | Key Costumer |
| Juanita Santamaria | Key Makeup Artist |
| Nana Fischer | Makeup Designer |
| Geri Doherty | Set Costumer |
| Giselle Guevara | Set Costumer |
| Manuela Galvez | Set Costumer |
| Margaret Pescott | Tailor |
| Ray Marston | Wigmaker |
| Aidan Monaghan | Still Photographer |
| Julie Lillis | Art Department Coordinator |
| Peter N. Brown | Construction Manager |
| Jean-Vincent Puzos | Production Design |
| Naomi Moore | Set Decoration |
| Teddy Blanks | Title Designer |
| Paul Carter | Property Master |
| Archie Campbell-Baldwin | Draughtsman |
| César Montoya | Art Direction |
| Emilia Roux | Art Direction |
| Fiona Gavin | Art Direction |
| John Merry | Art Direction |
| Nigel Pollock | Art Direction |
| Adam Dale | Aerial Director of Photography |
| David Grann | Novel |
| Alex Boyd | Production Manager |
| Marc Butan | Executive Producer |
| Mark Huffam | Executive Producer |
| Felipe Aljure | Executive Producer |
| George Drakoulias | Music Supervisor |
| Randall Poster | Music Supervisor |
| Aidan Elliott | Co-Producer |
| Doug Torres | Co-Producer |
| Anthony Katagas | Unit Production Manager |
| Doug Torres | First Assistant Director |
| James Smith | Unit Production Manager |
| Sarah Hood | Second Assistant Director |
| Florence Ortiz | Second Assistant Director |
| Philip Stephanou | Second Assistant Director |
| Luca Borghese | Associate Producer |
| Emily Austin Griswold | VFX Artist |
| Scott Morris | First Assistant Editor |
| Lew Horwitz | Executive Producer |
| Michael Ilitch Jr. | Executive Producer |
| Julie B. May | Executive Producer |
| Glenn Murray | Executive Producer |
| Nora Takacs Ekberg | Art Direction |
| Heather Greenlees | Art Direction |
| Maria Andrea Rangel | Set Decoration |
