 | Joseph Cotten als Eugene Morgan |
 | Dolores Costello als Isabel Amberson Minafer |
 | Anne Baxter als Lucy Morgan |
 | Tim Holt als George Minafer |
 | Agnes Moorehead als Fanny Minafer |
 | Ray Collins als Jack Amberson |
 | Erskine Sanford als Roger Bronson |
 | Richard Bennett als Major Amberson |
 | Orson Welles als Narrator (voice) |
 | Edwin August als Citizen (uncredited) |
 | Georgia Backus als Matron (uncredited) |
 | Harry A. Bailey als Citizen (uncredited) |
| Olive Ball als Mary (Maid) (uncredited) |
| Jack Baxley als Reverend Smith (uncredited) |
| William Blees als Young Man at Accident (uncredited) |
| Lyle Clement als Citizen (uncredited) |
| Bobby Cooper als George Minafer as a Boy (uncredited) |
 | Don Dillaway als Wilbur Minafer (uncredited) |
| Heenan Elliott als Workman (uncredited) |
 | John Elliott als Guest (uncredited) |
 | William Elmer als Servant (uncredited) |
| James Fawcett als Citizen (uncredited) |
| Mel Ford als Fred Kinney (uncredited) |
 | Nancy Gates als Girl (uncredited) |
| Nina Guilbert als Guest (uncredited) |
 | Maynard Holmes als Citizen (uncredited) |
| Edward Howard als Chauffeur (uncredited) |
 | Harry Humphrey als Citizen (uncredited) |
| Elmer Jerome als Funeral Attendee (uncredited) |
| J. Louis Johnson als Sam (Butler) (uncredited) |
 | Lew Kelly als Citizen (uncredited) |
| Del Lawrence als Citizen (uncredited) |
| Bert LeBaron als Citizen (uncredited) |
 | John McGuire als Young Man (uncredited) |
| Philip Morris als Policeman (uncredited) |
 | Anne O'Neal als Mrs. Foster (uncredited) |
| Gil Perkins als Citizen (uncredited) |
| Charles R. Phipps als Uncle John (uncredited) |
| Hilda Plowright als Nurse (uncredited) |
| Drew Roddy als Elijah (uncredited) |
| Henry Roquemore als Hardware Man (uncredited) |
| Jack Santoro als Barber (uncredited) |
 | Gus Schilling als Drug Clerk (uncredited) |
 | Kathryn Sheldon als Matron (uncredited) |
| Sada Simmons als Wife (uncredited) |
 | Dorothy Vaughan als Mrs. Johnson (uncredited) |
 | James Westerfield als Policeman at Accident (uncredited) |
| Joe Whitehead als Citizen (uncredited) |
| Orson Welles | Director |
| Orson Welles | Screenplay |
| Orson Welles | Producer |
| Bernard Herrmann | Original Music Composer |
| Stanley Cortez | Director of Photography |
| Albert S. D'Agostino | Production Design |
| Darrell Silvera | Set Decoration |
| Edward Stevenson | Costume Design |
| Vernon L. Walker | Special Effects |
| Mel Berns | Makeup Department Head |
| Booth Tarkington | Novel |
| Robert Wise | Editor |
| A. Roland Fields | Set Dresser |
| Mark-Lee Kirk | Set Designer |
| Fred Fleck | Assistant Director |
| Bill McLellan | Gaffer |
| Fred Fleck | Unit Manager |
| Claire Cramer | Wardrobe Designer |
| George Schaefer | Executive Producer |
| Jack Moss | Associate Producer |
| Orson Welles | Additional Photography |
| Jack MacKenzie | Additional Photography |
| Jack Moss | Additional Editing |
| Mark Robson | Additional Editing |
| Robert J. Schiffer | Makeup Artist |
| Maurice Seiderman | Makeup Artist |
| Harry Mancke | Assistant Director |
| Chesley Bonestell | Other |
| Bailey Fesler | Sound Recordist |
| James G. Stewart | Sound Recordist |
| Terry Kellum | Sound |
| Roy Meadows | Boom Operator |
| Earl B. Mounce | Sound |
| James Thompson | Boom Operator |
| John E. Tribby | Sound |
| Clifford Stine | Visual Effects |
| Robert Wise | Assistant Director |
| David Sharpe | Stunt Double |
| Helen Thurston | Stunt Double |
