 | Boris Karloff als Dr. Fu Manchu |
 | Lewis Stone als Nyland Smith |
 | Karen Morley als Sheila Barton |
 | Charles Starrett als Terence Granville |
 | Myrna Loy als Fah Lo See |
 | Jean Hersholt als Von Berg |
 | Lawrence Grant als Sir Lionel Barton |
 | David Torrence als McLeod |
 | C. Montague Shaw als Curator Dr. Fairgyle - British Museum Official (uncredited) |
 | Steve Clemente als Knife Thrower (uncredited) |
 | Allen Jung als Coolie (uncredited) |
 | Chris-Pin Martin als Potentate (uncredited) |
 | Edward Peil Sr. als Coolie Spy (uncredited) |
 | Willie Fung als Ship's Steward (uncredited) |
 | E. Alyn Warren als Goy Lo Sung - Fu Manchu Messenger (uncredited) |
 | Olive Young als Cantina singer (uncredited) |
 | Everett Brown als Slave (uncredited) |
 | Clinton Rosemond als Slave (uncredited) |
| Cedric Gibbons | Assistant Art Director |
| Cecil Holland | Makeup Artist |
| Irene Kuhn | Screenplay |
| Charles Vidor | Producer |
| Ben Lewis | Editor |
| Adrian | Costume Design |
| John Willard | Screenplay |
| Tony Gaudio | Director of Photography |
| Edgar Allan Woolf | Screenplay |
| Charles Brabin | Director |
| Douglas Shearer | Sound Director |
| Warren Newcombe | Special Effects |
| Ken Strickfaden | Stunt Double |
| Anstruther MacDonald | Sound |
| Clarence Sinclair Bull | Still Photographer |
| John Waters | Assistant Director |
| William Axt | Original Music Composer |
| Ken Strickfaden | Special Effects |
| Sax Rohmer | Novel |
