 | Keanu Reeves als Thomas A. Anderson / Neo |
 | Laurence Fishburne als Morpheus |
 | Carrie-Anne Moss als Trinity |
 | Hugo Weaving als Agent Smith |
 | Jada Pinkett Smith als Niobe |
 | Gloria Foster als Oracle |
 | Harold Perrineau als Link |
 | Monica Bellucci als Persephone |
 | Harry Lennix als Commander Lock |
 | Lambert Wilson als The Merovingian |
 | Randall Duk Kim als The Keymaker |
 | Nona Gaye als Zee |
 | Anthony Zerbe als Councillor Hamann |
 | Daniel Bernhardt als Agent Johnson |
 | Helmut Bakaitis als The Architect |
 | David Kilde als Agent Jackson |
 | Matt McColm als Agent Thompson |
 | Collin Chou als Seraph |
 | Neil Rayment als Twin #1 |
 | Adrian Rayment als Twin #2 |
 | Don Battee als Vector |
 | Valerie Berry als Priestess |
 | Steve Bastoni als Soren |
 | Ian Bliss als Bane |
 | Liliana Bogatko als Old Woman at Zion |
 | Michael Budd als Zion Controller |
| Stoney Burke als Bike Carrier Driver |
| Kelly Butler als Ice |
 | Josephine Byrnes als Zion Virtual Control Operator |
| Noris Campos als Woman with Groceries |
| Paul Cotter als Corrupt |
 | Marlene Cummins als Another Old Woman at Zion |
| Attila Davidhazy als Young Thomas Anderson at 12 |
 | Essie Davis als Maggie |
| Terrell Dixon als Wurm |
 | Nash Edgerton als Security Guard #5 |
 | David Franklin als Maitre D' |
 | Daryl Heath als A.P.U. Escort |
 | Roy Jones Jr. als Captain Ballard |
| Austin Galuppo als Young Thomas Anderson at 4 |
 | Malcolm Kennard als Abel |
 | Christopher Kirby als Mauser |
| Peter Lamb als Colt |
 | Nathaniel Lees als Mifune |
 | Tony Lynch als Computer Room Technician |
 | Robert Mammone als AK |
| Joshua Mbakwe als Link's Nephew |
| Chris Mitchell als Power Station Guard |
| Steve Morris als Computer Room Guard |
 | Tory Mussett als Beautiful Woman at Le Vrai |
 | Rene Naufahu als Zion Gate Operator |
 | Robyn Nevin als Councillor Dillard |
 | David William No als Cain |
 | Genevieve O'Reilly als Officer Wirtz |
 | Socratis Otto als Operator |
 | Montaño Rain als Young Thomas Anderson at 8 |
 | Rupert Reid als Lock's Lieutenant |
 | Cornel West als Councillor West |
 | David Roberts als Roland |
| Shane C. Rodrigo als Ajax |
 | Nick Scoggin als Gidim Truck Driver |
 | Kevin Scott als 18 Wheel Trucker |
| Tahei Simpson als Binary |
 | Frankie Stevens als Tirant |
| Nicandro Thomas als Young Thomas Anderson at 2 |
 | Gina Torres als Cas |
| Andrew Valli als Police #1 |
 | Andy Arness als Police #2 |
 | Steve Vella als Malachi |
 | John Walton als Security Bunker Guard |
 | Clayton Watson als Kid |
 | Leigh Whannell als Axel |
 | Bernard White als Rama-Kandra |
| Scott McLean als Security Bunker Guard #2 |
 | Anthony Brandon Wong als Ghost |
 | Christine Anu als Kali |
| Ray Anthony als Power Station Guard |
 | Rick Shuster als Pilot (uncredited) |
 | Tiger Hu Chen als Merovingian's Thug (uncredited) |
 | Marcus Young als Merovingian's Thug (uncredited) |
 | David Leitch als Merovingian's Thug (uncredited) |
| Jules Cook | Art Direction |
| Hank Amos | Stunts |
| Lana Wachowski | Screenplay |
| Mali Finn | Casting |
| Kenny Alexander | Stunts |
| Kym Barrett | Costume Design |
| Owen Paterson | Production Design |
| Shauna Wolifson | Casting |
| Bill Pope | Director of Photography |
| Eric Allard | Special Effects |
| Zach Staenberg | Editor |
| Hugh Bateup | Art Direction |
| Richard Adrian | Sound Designer |
| Mayumi Arakaki | Visual Effects |
| Don Davis | Original Music Composer |
| Lana Wachowski | Director |
| Lilly Wachowski | Screenplay |
| Ronald R. Reiss | Set Decoration |
| Barney Burman | Makeup Artist |
| Lilly Wachowski | Director |
| Joel Silver | Producer |
| Brian Dusting | Set Decoration |
| James McTeigue | Assistant Director |
| Gregg Rudloff | Sound Re-Recording Mixer |
| Brice R. Parker | Visual Effects Coordinator |
| John 'D.J.' Des Jardin | Visual Effects Supervisor |
| David Lee | Sound Recordist |
| Brad Martin | Stunt Double |
| Brad Martin | Stunts |
| Marc Gabbana | Concept Artist |
| Tory Belleci | Modeling |
| Yuen Woo-Ping | Fight Choreographer |
| Lilly Wachowski | Executive Producer |
| Lana Wachowski | Executive Producer |
| Grant Hill | Executive Producer |
| Andrew Mason | Executive Producer |
| Bruce Berman | Executive Producer |
| L. Dean Jones Jr. | Unit Production Manager |
| Grant Hill | Unit Production Manager |
| James McTeigue | First Assistant Director |
| Claire Richardson | Second Assistant Director |
| Sean Hobin | Second Assistant Director |
| Dane A. Davis | Sound Designer |
| Dane A. Davis | Supervising Sound Editor |
| Geofrey Darrow | Conceptual Design |
| Vicki Popplewell | Associate Producer |
| Steve Richards | Associate Producer |
| Troy Brown | Stunts |
| Danielle Burgio | Stunts |
| Rocky Capella | Stunts |
| Brian Duffy | Stunts |
| Annie Ellis | Stunts |
| Mike Gunther | Stunts |
| Jim Pratt | Stunts |
| Troy Robinson | Stunts |
| Tommy J. Huff | Stunts |
| Tim Rigby | Stunts |
| Kevin Larson | Stunts |
| Rex Reddick | Stunts |
| Ronn Surels | Stunts |
| Marcus Young | Stunts |
| Danny Wynands | Stunts |
| Tim Walkey | Stunts |
| Chad Randall | Stunts |
| Ashley Fairfield | Stunts |
| Tim Connolly | Stunts |
| Mike Massa | Stunts |
| John T. Cypert | Stunts |
| Paul Crawford | Stunts |
| Debbie Evans | Stunts |
| Peter Jeremijenko | Stunts |
| Freddie Hice | Stunts |
| Clay Donahue Fontenot | Stunts |
| Thomas Robinson Harper | Stunts |
| Will Leong | Stunts |
| Erik Rondell | Stunts |
| Larry Rippenkroeger | Stunts |
| Nigel Harbach | Stunts |
| Andre McCoy | Stunts |
| Billy D. Lucas | Stunts |
| Chris O'Hara | Stunts |
| Jimmy N. Roberts | Stunts |
| Mike Mukatis | Stunts |
| Pat Romano | Stunts |
| Tim Trella | Stunts |
| Jeff Mosley | Stunts |
| Melanie Peyton-Smith | Stunts |
| Ousaun Elam | Stunts |
| Alex Kuzelicki | Stunts |
| Bernadette Van Gyen | Stunts |
| Gilbert B. Combs | Stunts |
| Steve Holladay | Stunts |
| Gary Ray Stearns | Stunts |
| Rick Shuster | Pilot |
| Craig Hosking | Pilot |
| Gary Ticehurst | Pilot |
| Hugh Bateup | Supervising Art Director |
| Philip Keller | Storyboard Artist |
| Simon Murton | Concept Artist |
| Darek Gogol | Concept Artist |
| Catherine Mansill | Art Direction |
| Charlie Revai | Art Direction |
| Damien Drew | Assistant Art Director |
| Cindi Knapton | Assistant Art Director |
| Karen Murphy | Assistant Art Director |
| Michael Turner | Assistant Art Director |
| Godric Cole | Set Designer |
| Christian Huband | Set Designer |
| Mark W. Mansbridge | Art Direction |
| Victoria Sullivan | Script Supervisor |
| Gerry Nucifora | Boom Operator |
| Scott Kinzey | Boom Operator |
| John Bowring | Armorer |
| Peter Cogar | Armorer |
| Belinda Villani | Sculptor |
| Mike Blaze | Property Master |
| Reg Garside | Gaffer |
| Bob Finley III | Chief Lighting Technician |
| Ian Bird | Key Grip |
| Michael Vivian | Dolly Grip |
| Aron Walker | Dolly Grip |
| Jay Munro | Best Boy Grip |
| Martin Fargher | Grip |
| John Regan | Grip |
| Tony Mazzucchi | Key Grip |
| Joseph J. Allen | Grip |
| Steve Courtley | Special Effects Supervisor |
| Clay Pinney | Special Effects Supervisor |
| Peter Robb-King | Makeup Department Head |
| Maggie Fung | Key Makeup Artist |
| Deborah Taylor | Key Makeup Artist |
| Tina Gordon | Makeup Artist |
| Margaret Aston | Makeup Artist |
| Karen Bradley | Makeup Artist |
| Jenny-King Turko | Makeup Artist |
| Steven E. Anderson | Makeup Artist |
| Judith A. Cory | Hair Department Head |
| Dan Bronson | Costume Supervisor |
| Elaine Ramires | Key Costumer |
| Peggy A. Schnitzer | Key Costumer |
| Chandra Moore-Telfer | Ager/Dyer |
| Rebeka L. Roberts | Ager/Dyer |
| Jody Rogers | Visual Effects Editor |
| Jessica Alan | Post Production Supervisor |
| Julia Evershade | Supervising Sound Editor |
| Eric Lindemann | Sound Effects Designer |
| Eric Lindemann | Sound Effects Editor |
| Andrew Lackey | Sound Effects Editor |
| Michael Edward Johnson | Sound Effects Editor |
| Mark Larry | Sound Effects Editor |
| Richard Adrian | Sound Effects Editor |
| Michael W. Mitchell | Sound Effects Editor |
| Stephanie Flack | Supervising Dialogue Editor |
| Stephanie Brown | ADR Editor |
| Nancy Barker | First Assistant Sound Editor |
| Eryne Prine | Assistant Sound Editor |
| David Kudell | Assistant Sound Editor |
| Paul Hackner | Assistant Sound Editor |
| John Roesch | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| Mary Jo Lang | Foley Mixer |
| David Jobe | Foley Mixer |
| Scott Morgan | Foley Recordist |
| Thomas J. O'Connell | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Barbara Harris | ADR Voice Casting |
| John T. Reitz | Sound Re-Recording Mixer |
| David E. Campbell | Sound Re-Recording Mixer |
| Joe E. Rand | Music Editor |
| Zigmund Gron | Music Editor |
| Dan Glass | Visual Effects Supervisor |
| Terry Clotiaux | Visual Effects Producer |
| Josh R. Jaggars | Digital Effects Producer |
| Amanda Crittenden | Production Supervisor |
| Gerald Scaife | Production Supervisor |
| Jacqueline King | Production Coordinator |
| Debra James | Production Supervisor |
| Mimi N. McGreal | Travel Coordinator |
| Cathy Marshall-Hart | Payroll Accountant |
| Mandy Butler | Production Accountant |
| Lisa Jean Felski | First Assistant Accountant |
| Caryn Cheever | Second Assistant Accountant |
| Linden Johnson | Assistant Accountant |
| Beth Bargas | Assistant Accountant |
| Adrienne Swan | Assistant Accountant |
| Peter Lawless | Location Manager |
| David L. Wolfson | Location Manager |
| Peter Martorano | Assistant Location Manager |
| Deborah Antoniou | Second Second Assistant Director |
| Paul Sullivan | Second Second Assistant Director |
| John M. Morse | Second Second Assistant Director |
| Lindsey Hayes Kroeger | Casting Associate |
| David Rapaport | Casting Assistant |
| Beau Bonneau | Extras Casting |
| Henrie Stride | Extras Casting Assistant |
| Suzanne Celeste | Dialect Coach |
| Susan Hegarty | Dialect Coach |
| Fiona Searson | Unit Publicist |
| Bronwyn Preston | Unit Publicist |
| Mary-Liz Andrews | Construction Coordinator |
| Ian Bickerton | Construction Foreman |
| Butch West | Construction Coordinator |
| Michael Antunez | Transportation Coordinator |
| Bruce Hauer | Transportation Captain |
| Kimble Rendall | Second Unit Director |
| Ross Emery | Second Unit Director of Photography |
| Toby Pease | Second Unit First Assistant Director |
| David R. Ellis | Second Unit Director |
| Kim Marks | Second Unit Director of Photography |
| Michael Green | Second Unit First Assistant Director |
| Adrien Seffrin | First Assistant Camera |
| Roger Lanser | Additional Director of Photography |
| Jeff Lew | Lead Animator |
| Debbie Evans | Stunt Double |
| Chad Stahelski | Stunt Coordinator |
| David Leitch | Stunts |
| Ronnie Rondell Jr. | Stunts |
| Glenn Boswell | Stunt Coordinator |
| Dion Lam Dik-On | Fight Choreographer |
| Yuen Cheung-Yan | Stunts |
| Tiger Hu Chen | Stunts |
| Tony Ling Chi-Wah | Stunts |
| Ku Huen-Chiu | Stunts |
| Lam Chi-Tai | Stunts |
| Yuen Shun-Yi | Stunts |
| Steve Skroce | Storyboard Artist |
| John Gaeta | Visual Effects Supervisor |
| Henry Kingi | Stunt Driver |
| John C. Meier | Stunt Driver |
| Jeffrey J. Dashnaw | Stunts |
| Darrin Prescott | Stunts |
| Justin Folk | Visual Effects Assistant Editor |
| George Hull | Visual Effects Art Director |
