 | Leslie Nielsen als Lt. Frank Drebin |
 | Priscilla Presley als Jane Spencer |
 | Ricardo Montalban als Vincent Ludwig |
 | George Kennedy als Capt. Ed Hocken |
 | O.J. Simpson als Det. Nordberg |
 | Susan Beaubian als Mrs. Wilma Nordberg |
 | Nancy Marchand als Mayor |
 | Raye Birk als Pahpshmir |
 | Jeannette Charles als Queen Elizabeth II |
 | Ed Williams als Ted Olsen |
 | Tiny Ron als Al |
 | 'Weird Al' Yankovic als 'Weird Al' |
 | Leslie Maier als 'Weird Leslie' |
 | Winifred Freedman als Stephanie |
 | Joe Grifasi als Foreman |
| Tony Brafa als Enrico Pallazzo |
 | Lorali Hart als Woman On Ledge |
 | Nicholas Worth als Thug #1 |
 | Ronald G. Joseph als Thug #27 |
| Doris Hess als Nurse #2 |
 | Charlotte Zucker als Dominique |
| Larry Pines als Drug Dealer #1 |
 | Tom Dugan als Drug Dealer #2 |
 | Burton Zucker als Photographer |
| David Katz als Arafat |
| Robert LuJane als Khadafi |
 | Charles Gherardi als Khomeini |
 | Prince Hughes als Idi Amin |
| David Lloyd Austin als Gorbachev |
| Ken Minyard als Ken (voice) |
| Robert Arthur als Bob (voice) |
| Greg Breslau als Man Deleted from Fireworks Scene |
| Sharon Breslau als Woman Deleted from Fireworks Scene |
 | Reggie Jackson als Angel Right Fielder |
| Michael J. Montes als Angel Shortstop |
| Charles Fick als Angel Catcher |
 | Lawrence Tierney als Angels Manager |
| Hank Robinson als First Base Umpire |
| Joe West als Third Base Umpire |
| Jay Johnstone als Seattle First Up |
| Randy Harvey als Angels Pitcher |
| Brett Bartlett als Seattle Centerfielder |
| Dennis Packer als Baseball P.A. Announcer |
 | Dick Vitale als Baseball Announcer |
 | Dick Enberg als Baseball Announcer |
 | Jim Palmer als Baseball Announcer |
| Mel Allen als Baseball Announcer |
| Curt Gowdy als Baseball Announcer |
| Tim McCarver als Baseball Announcer |
 | Joyce Brothers als Baseball Announcer |
| Don Woodard als "There he is!" |
| Christopher J. Keene als "Please disperse, Please disperse." |
| Mary Norman als "Here, you can use my radio mike." |
| Susan Breslau als "Hey, look out!" |
| Rick Seaman als "Ya dumb broad!" |
| Fredric Arnold als "Hey! What's the meaning of this?" |
| Ron Tank als Reporter |
 | Mallory Sandler als Nurse |
| Edwina Moore als Usher |
 | Jeff Wright als "Mr. Pallazzo! Would you come with me?" |
| Jim Smith als "Sorry, fellas." |
 | Mark Holton als "It's Enrico Pallazzo!" |
| Jane Couris als "You killed him!" |
 | John Houseman als Driving Instructor (uncredited) |
 | Brinke Stevens als Brunette Woman in Showers (uncredited) |
 | Jesse Ventura als Baseball Announcer (uncredited) |
| Jerry Zucker | Writer |
| Jim Abrahams | Writer |
| David Zucker | Writer |
| Pat Proft | Writer |
| Jim Abrahams | Executive Producer |
| Robert K. Weiss | Producer |
| David Zucker | Executive Producer |
| Jerry Zucker | Executive Producer |
| David Zucker | Director |
| John D. Schofield | Associate Producer |
| Kevin Marcy | Associate Producer |
| Ira Newborn | Original Music Composer |
| Michael Jablow | Editor |
| Pamela Basker | Casting |
| Fern Champion | Casting |
| John J. Lloyd | Production Design |
| Donald B. Woodruff | Art Direction |
| Rick Gentz | Set Decoration |
| Mary E. Vogt | Costume Design |
| Phil Read | Construction Coordinator |
| James Passanante | Lead Painter |
| Martin A. Kline | Production Illustrator |
| Andrew Neskoromny | Set Designer |
| Michael D. O'Shea | Camera Operator |
| Elliott Marks | Still Photographer |
| Nick Scarano | Costume Supervisor |
| Robert Ryan | Makeup Artist |
| Richard Baum | Set Dressing Artist |
| John Nesterowicz | Craft Service |
| Rick Wiley | Driver |
| Lisa Rocco | Makeup Effects |
| Rita Grant Miller | Production Office Coordinator |
| Michael A. Tice | Propmaker |
| Jack E. Ackerman | Property Master |
| Huey Redwine | Stand In |
| Conrad E. Palmisano | Stunt Coordinator |
| Nick Dimitri | Stunts |
| Robert E. McLaughlin | Transportation Co-Captain |
| Vince del Castillo | Transportation Coordinator |
| John D. Schofield | Unit Production Manager |
| Reid Rosefelt | Unit Publicist |
| John T. Kretchmer | First Assistant Director |
| Nancy Hopton | Script Supervisor |
| Sue Swan | Casting Associate |
| Cass Martin | Location Manager |
| Joseph F. Brennan | Boom Operator |
| Donald Ortiz | Assistant Sound Editor |
| Alf Clausen | Orchestrator |
| Frank Howard | Sound Editor |
| Thomas Causey | Sound Mixer |
| George Watters II | Supervising Sound Editor |
| Cliff Wenger | Special Effects Supervisor |
| Bruce A. Block | Visual Effects Supervisor |
| Robert M. Stevens | Director of Photography |
| David B. Miller | Makeup Supervisor |
| Geraldine F. Keener | Second Second Assistant Director |
| Stephen Adler | Assistant Property Master |
| Chris Woodworth | Set Painter |
| Greg Curda | Foley Mixer |
| Bruce Paul Barbour | Stunt Double |
| Harold Burns | Stunt Driver |
| Michael T. Travers | Best Boy Grip |
| Jack Glenn | Dolly Grip |
| Gene Griffith | First Company Grip |
| Willie McClean | Second Company Grip |
| Lindsay Chag | Casting Assistant |
| Jeff Carson | Supervising Music Editor |
| Benny McNulty | Assistant Chief Lighting Technician |
| Leslie J. Kovacs | Chief Lighting Technician |
| Ken Marschall | Matte Painter |
| Timothy R. McWilliams | Production Assistant |
| Mary Peters | Stunts |
| Jeannie Epper | Stunts |
| Debbie Evans | Stunts |
| Diane Peterson | Stunts |
| Richard Stevens | Camera Loader |
